Publication list - Publika - Scientific publications from Oslo University Hospital

Publications by Vegard Eldholm

54 publications found

Original articles

Nimmo C, Ortiz AT, Tan CCS, Pang J, Acman M, Millard J, Padayatchi N, Grant AD, O'Donnell M, Pym A, Brynildsrud OB, Eldholm V, Grandjean L, Didelot X, Balloux F, van Dorp L (2024)
Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis
Genome Med, 16 (1), 34
DOI 10.1186/s13073-024-01289-5, PubMed 38374151

Garcia I, Lee Y, Brynildsrud O, Eldholm V, Magnus P, Blomfeldt A, Leegaard TM, Müller F, Dudman S, Caugant DA (2023)
Tracing the adaptive evolution of SARS-CoV-2 during vaccine roll-out in Norway
Virus Evol, 10 (1), vead081
DOI 10.1093/ve/vead081, PubMed 38205440

Vollan HS, Caugant DA, Eldholm V, Alfsnes K, Debech N, Brynildsrud O (2022)
Naturally occurring Neisseria gonorrhoeae can have large deletions in housekeeping gene abcZ, making them untypable with multilocus sequence typing
Microb Genom, 8 (9)
DOI 10.1099/mgen.0.000889, PubMed 36136059

Bohr LL, Youngblom MA, Eldholm V, Pepperell CS (2021)
Genome reorganization during emergence of host-associated Mycobacterium abscessus
Microb Genom, 7 (12)
DOI 10.1099/mgen.0.000706, PubMed 34874249

Alfsnes K, Eldholm V, Gaunt MW, de Lamballerie X, Gould EA, Pettersson JH (2021)
Tracing and tracking the emergence, epidemiology and dispersal of dengue virus to Africa during the 20th century
One Health, 13, 100337
DOI 10.1016/j.onehlt.2021.100337, PubMed 34746356

Osnes MN, Alfsnes K, Bråte J, Garcia I, Riis RK, Instefjord KH, Elshaug H, Vollan HS, Moen LV, Pedersen BN, Caugant DA, Stene-Johansen K, Hungnes O, Bragstad K, Brynildsrud O, Eldholm V (2021)
The impact of global lineage dynamics, border restrictions, and emergence of the B.1.1.7 lineage on the SARS-CoV-2 epidemic in Norway
Virus Evol, 7 (2), veab086
DOI 10.1093/ve/veab086, PubMed 34659798

Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B (2021)
Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova
Microb Genom, 7 (8)
DOI 10.1099/mgen.0.000620, PubMed 34431762

Eldholm V, Rønning JO, Mengshoel AT, Arnesen T (2021)
Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway
BMC Infect Dis, 21 (1), 562
DOI 10.1186/s12879-021-06269-3, PubMed 34118874

MacAlasdair N, Pesonen M, Brynildsrud O, Eldholm V, Kristiansen PA, Corander J, Caugant DA, Bentley SD (2021)
The effect of recombination on the evolution of a population of Neisseria meningitidis
Genome Res, 31 (7), 1258-1268
DOI 10.1101/gr.264465.120, PubMed 34108268

Osnes MN, Dorp LV, Brynildsrud OB, Alfsnes K, Schneiders T, Templeton KE, Yahara K, Balloux F, Caugant DA, Eldholm V (2021)
Antibiotic Treatment Regimes as a Driver of the Global Population Dynamics of a Major Gonorrhea Lineage
Mol Biol Evol, 38 (4), 1249-1261
DOI 10.1093/molbev/msaa282, PubMed 33432328

Yahara K, Ma KC, Mortimer TD, Shimuta K, Nakayama SI, Hirabayashi A, Suzuki M, Jinnai M, Ohya H, Kuroki T, Watanabe Y, Yasuda M, Deguchi T, Eldholm V, Harrison OB, Maiden MCJ, Grad YH, Ohnishi M (2021)
Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae
Genome Med, 13 (1), 51
DOI 10.1186/s13073-021-00860-8, PubMed 33785063

Osnes MN, Didelot X, Korne-Elenbaas J, Alfsnes K, Brynildsrud OB, Syversen G, Nilsen ØJ, De Blasio BF, Caugant DA, Eldholm V (2020)
Sudden emergence of a Neisseria gonorrhoeae clade with reduced susceptibility to extended-spectrum cephalosporins, Norway
Microb Genom, 6 (12)
DOI 10.1099/mgen.0.000480, PubMed 33200978

Alfsnes K, Eldholm V, Olsen AO, Brynildsrud OB, Bohlin J, Steinbakk M, Caugant DA (2020)
Genomic epidemiology and population structure of Neisseria gonorrhoeae in Norway, 2016-2017
Microb Genom, 6 (4)
DOI 10.1099/mgen.0.000359, PubMed 32213251

Monteserin J, Pérez-Lago L, Yokobori N, Paul R, Rodríguez Maus S, Simboli N, Eldholm V, López B, García de Viedma D, Ritacco V (2019)
Trends of Two Epidemic Multidrug-Resistant Strains of Mycobacterium tuberculosis in Argentina Disclosed by Tailored Molecular Strategy
Am J Trop Med Hyg, 101 (6), 1308-1311
DOI 10.4269/ajtmh.19-0397, PubMed 31628738

Brown TS, Challagundla L, Baugh EH, Omar SV, Mustaev A, Auld SC, Shah NS, Kreiswirth BN, Brust JCM, Nelson KN, Narechania A, Kurepina N, Mlisana K, Bonneau R, Eldholm V, Ismail N, Kolokotronis SO, Robinson DA, Gandhi NR, Mathema B (2019)
Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa
Proc Natl Acad Sci U S A, 116 (46), 23284-23291
DOI 10.1073/pnas.1906636116, PubMed 31659018

Pettersson JH, Piorkowski G, Mayxay M, Rattanavong S, Vongsouvath M, Davong V, Alfsnes K, Eldholm V, de Lamballerie X, Holmes EC, Newton PN, Dubot-Pérès A (2019)
Meta-transcriptomic identification of hepatitis B virus in cerebrospinal fluid in patients with central nervous system disease
Diagn Microbiol Infect Dis, 95 (4), 114878
DOI 10.1016/j.diagmicrobio.2019.114878, PubMed 31451314

Brynildsrud OB, Eldholm V, Rakhimova A, Kristiansen PA, Caugant DA (2019)
Gauging the epidemic potential of a widely circulating non-invasive meningococcal strain in Africa
Microb Genom, 5 (8)
DOI 10.1099/mgen.0.000290, PubMed 31454306

O'Neill MB, Shockey A, Zarley A, Aylward W, Eldholm V, Kitchen A, Pepperell CS (2019)
Lineage specific histories of Mycobacterium tuberculosis dispersal in Africa and Eurasia
Mol Ecol, 28 (13), 3241-3256
DOI 10.1111/mec.15120, PubMed 31066139

van Dorp L, Wang Q, Shaw LP, Acman M, Brynildsrud OB, Eldholm V, Wang R, Gao H, Yin Y, Chen H, Ding C, Farrer RA, Didelot X, Balloux F, Wang H (2019)
Rapid phenotypic evolution in multidrug-resistant Klebsiella pneumoniae hospital outbreak strains
Microb Genom, 5 (4)
DOI 10.1099/mgen.0.000263, PubMed 30939107

Brynildsrud OB, Pepperell CS, Suffys P, Grandjean L, Monteserin J, Debech N, Bohlin J, Alfsnes K, Pettersson JO, Kirkeleite I, Fandinho F, da Silva MA, Perdigao J, Portugal I, Viveiros M, Clark T, Caws M, Dunstan S, Thai PVK, Lopez B, Ritacco V, Kitchen A, Brown TS, van Soolingen D, O'Neill MB et al. (2018)
Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation
Sci Adv, 4 (10), eaat5869
DOI 10.1126/sciadv.aat5869, PubMed 30345355

Alfsnes K, Frye SA, Eriksson J, Eldholm V, Brynildsrud OB, Bohlin J, Harrison OB, Hood DW, Maiden MCJ, Tønjum T, Ambur OH (2018)
A genomic view of experimental intraspecies and interspecies transformation of a rifampicin-resistance allele into Neisseria meningitidis
Microb Genom, 4 (11)
DOI 10.1099/mgen.0.000222, PubMed 30251949

Ayabina D, Ronning JO, Alfsnes K, Debech N, Brynildsrud OB, Arnesen T, Norheim G, Mengshoel AT, Rykkvin R, Dahle UR, Colijn C, Eldholm V (2018)
Genome-based transmission modelling separates imported tuberculosis from recent transmission within an immigrant population
Microb Genom, 4 (10)
DOI 10.1099/mgen.0.000219, PubMed 30216147

Bohlin J, Eldholm V, Brynildsrud O, Petterson JH, Alfsnes K (2018)
Modeling of the GC content of the substituted bases in bacterial core genomes
BMC Genomics, 19 (1), 589
DOI 10.1186/s12864-018-4984-3, PubMed 30081825

Pettersson JH, Bohlin J, Dupont-Rouzeyrol M, Brynildsrud OB, Alfsnes K, Cao-Lormeau VM, Gaunt MW, Falconar AK, de Lamballerie X, Eldholm V, Musso D, Gould EA (2018)
Re-visiting the evolution, dispersal and epidemiology of Zika virus in Asia
Emerg Microbes Infect, 7 (1), 79
DOI 10.1038/s41426-018-0082-5, PubMed 29739925

Brynildsrud OB, Eldholm V, Bohlin J, Uadiale K, Obaro S, Caugant DA (2018)
Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa
Proc Natl Acad Sci U S A, 115 (21), 5510-5515
DOI 10.1073/pnas.1802298115, PubMed 29735685

de Welzen L, Eldholm V, Maharaj K, Manson AL, Earl AM, Pym AS (2017)
Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance
Antimicrob Agents Chemother, 61 (12)
DOI 10.1128/AAC.01461-17, PubMed 28993337

Pettersson JH, Shi M, Bohlin J, Eldholm V, Brynildsrud OB, Paulsen KM, Andreassen Å, Holmes EC (2017)
Characterizing the virome of Ixodes ricinus ticks from northern Europe
Sci Rep, 7 (1), 10870
DOI 10.1038/s41598-017-11439-y, PubMed 28883464

Norheim G, Seterelv S, Arnesen TM, Mengshoel AT, Tønjum T, Rønning JO, Eldholm V (2017)
Tuberculosis Outbreak in an Educational Institution in Norway
J Clin Microbiol, 55 (5), 1327-1333
DOI 10.1128/JCM.01152-16, PubMed 28202795

Bohlin J, Eldholm V, Pettersson JH, Brynildsrud O, Snipen L (2017)
The nucleotide composition of microbial genomes indicates differential patterns of selection on core and accessory genomes
BMC Genomics, 18 (1), 151
DOI 10.1186/s12864-017-3543-7, PubMed 28187704

Bø K, Skullerud KH, Mengshoel AT, Eldholm V, Brantsæter AB (2017)
[Tattooed norwegian tourist with fever and rashes]
Tidsskr Nor Laegeforen, 137 (3), 205-207
DOI 10.4045/tidsskr.16.0710, PubMed 28181759

Brynildsrud O, Bohlin J, Scheffer L, Eldholm V (2016)
Rapid scoring of genes in microbial pan-genome-wide association studies with Scoary
Genome Biol, 17 (1), 238
DOI 10.1186/s13059-016-1108-8, PubMed 27887642

Eldholm V, Pettersson JH, Brynildsrud OB, Kitchen A, Rasmussen EM, Lillebaek T, Rønning JO, Crudu V, Mengshoel AT, Debech N, Alfsnes K, Bohlin J, Pepperell CS, Balloux F (2016)
Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis
Proc Natl Acad Sci U S A, 113 (48), 13881-13886
DOI 10.1073/pnas.1611283113, PubMed 27872285

Pettersson JH, Eldholm V, Seligman SJ, Lundkvist Å, Falconar AK, Gaunt MW, Musso D, Nougairède A, Charrel R, Gould EA, de Lamballerie X (2016)
How Did Zika Virus Emerge in the Pacific Islands and Latin America?
mBio, 7 (5)
DOI 10.1128/mBio.01239-16, PubMed 27729507

Eldholm V, Rieux A, Monteserin J, Lopez JM, Palmero D, Lopez B, Ritacco V, Didelot X, Balloux F (2016)
Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
Elife, 5
DOI 10.7554/eLife.16644, PubMed 27502557

Eldholm V, Monteserin J, Rieux A, Lopez B, Sobkowiak B, Ritacco V, Balloux F (2015)
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
Nat Commun, 6, 7119
DOI 10.1038/ncomms8119, PubMed 25960343

Eldholm V, Norheim G, von der Lippe B, Kinander W, Dahle UR, Caugant DA, Mannsåker T, Mengshoel AT, Dyrhol-Riise AM, Balloux F (2014)
Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient
Genome Biol, 15 (11), 490
DOI 10.1186/s13059-014-0490-3, PubMed 25418686

Eldholm V, Haugen A, Zienolddiny S (2013)
CTCF mediates the TERT enhancer-promoter interactions in lung cancer cells: identification of a novel enhancer region involved in the regulation of TERT gene
Int J Cancer, 134 (10), 2305-13
DOI 10.1002/ijc.28570, PubMed 24174344

Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall JM, Bjørås M, Meza-Zepeda LA, Enserink JM (2012)
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc Natl Acad Sci U S A, 109 (26), 10450-5
DOI 10.1073/pnas.1200067109, PubMed 22689984

Zimmermann C, Chymkowitch P, Eldholm V, Putnam CD, Lindvall JM, Omerzu M, Bjørås M, Kolodner RD, Enserink JM (2011)
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression
Proc Natl Acad Sci U S A, 108 (46), 18748-53
DOI 10.1073/pnas.1115885108, PubMed 22042866

Eldholm V, Johnsborg O, Straume D, Ohnstad HS, Berg KH, Hermoso JA, Håvarstein LS (2010)
Pneumococcal CbpD is a murein hydrolase that requires a dual cell envelope binding specificity to kill target cells during fratricide
Mol Microbiol, 76 (4), 905-17
DOI 10.1111/j.1365-2958.2010.07143.x, PubMed 20384696

Eldholm V, Gutt B, Johnsborg O, Brückner R, Maurer P, Hakenbeck R, Mascher T, Håvarstein LS (2010)
The pneumococcal cell envelope stress-sensing system LiaFSR is activated by murein hydrolases and lipid II-interacting antibiotics
J Bacteriol, 192 (7), 1761-73
DOI 10.1128/JB.01489-09, PubMed 20118250

Eldholm V, Johnsborg O, Haugen K, Ohnstad HS, Håvarstein LS (2009)
Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC
Microbiology (Reading), 155 (Pt 7), 2223-2234
DOI 10.1099/mic.0.026328-0, PubMed 19389766

Johnsborg O, Eldholm V, Bjørnstad ML, Håvarstein LS (2008)
A predatory mechanism dramatically increases the efficiency of lateral gene transfer in Streptococcus pneumoniae and related commensal species
Mol Microbiol, 69 (1), 245-53
DOI 10.1111/j.1365-2958.2008.06288.x, PubMed 18485065

Dahle UR, Eldholm V, Winje BA, Mannsåker T, Heldal E (2007)
Impact of immigration on the molecular epidemiology of Mycobacterium tuberculosis in a low-incidence country
Am J Respir Crit Care Med, 176 (9), 930-5
DOI 10.1164/rccm.200702-187OC, PubMed 17673698

Eldholm V, Matee M, Mfinanga SG, Heun M, Dahle UR (2006)
A first insight into the genetic diversity of Mycobacterium tuberculosis in Dar es Salaam, Tanzania, assessed by spoligotyping
BMC Microbiol, 6, 76
DOI 10.1186/1471-2180-6-76, PubMed 16970826

Review articles

Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, Nardell EA, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling AC, Mizrahi V, Rustomjee R, Pym A (2018)
Transmission of drug-resistant tuberculosis in HIV-endemic settings
Lancet Infect Dis, 19 (3), e77-e88
DOI 10.1016/S1473-3099(18)30537-1, PubMed 30554996

Balloux F, Brønstad Brynildsrud O, van Dorp L, Shaw LP, Chen H, Harris KA, Wang H, Eldholm V (2018)
From Theory to Practice: Translating Whole-Genome Sequencing (WGS) into the Clinic
Trends Microbiol, 26 (12), 1035-1048
DOI 10.1016/j.tim.2018.08.004, PubMed 30193960

Eldholm V, Balloux F (2016)
Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out
Trends Microbiol, 24 (8), 637-648
DOI 10.1016/j.tim.2016.03.007, PubMed 27068531

Johnsborg O, Eldholm V, Håvarstein LS (2007)
Natural genetic transformation: prevalence, mechanisms and function
Res Microbiol, 158 (10), 767-78
DOI 10.1016/j.resmic.2007.09.004, PubMed 17997281