RSS feed

Publications by Hilde Schjerven

31 publications found

Original articles

Podgorica M, Drivet E, Viken JK, Richman A, Vestbøstad J, Szodoray P, Kvam AK, Wik HS, Tjønnfjord GE, Munthe LA, Frietze S, Schjerven H (2024)
Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis
Eur J Haematol, 112 (5), 731-742
DOI 10.1111/ejh.14164, PubMed 38192186

Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR (2023)
Ikaros is a principal regulator of Aire⁺ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance
Sci Immunol, 8 (88), eabq3109
DOI 10.1126/sciimmunol.abq3109, PubMed 37889983

Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, Schjerven H, Frietze S (2022)
Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia
Epigenomes, 6 (4)
DOI 10.3390/epigenomes6040037, PubMed 36278683

Boyd J, Rodriguez P, Schjerven H, Frietze S (2021)
ssvQC: an integrated CUT&RUN quality control workflow for histone modifications and transcription factors
BMC Res Notes, 14 (1), 366
DOI 10.1186/s13104-021-05781-8, PubMed 34544495

Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-Supprian M, Frietze S, Ringshausen I (2020)
Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance
Sci Transl Med, 12 (526)
DOI 10.1126/scitranslmed.aax9340, PubMed 31941829

Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP (2018)
Cell circuits between B cell progenitors and IL-7⁺ mesenchymal progenitor cells control B cell development
J Exp Med, 215 (10), 2586-2599
DOI 10.1084/jem.20180778, PubMed 30158115

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA et al. (2018)
Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors
Nature, 558 (7711), E5
DOI 10.1038/s41586-018-0164-5, PubMed 29849140

Ye J, Qiu J, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L (2017)
The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells
Cell Rep, 21 (8), 2277-2290
DOI 10.1016/j.celrep.2017.10.114, PubMed 29166616

Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA (2017)
Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
Nat Immunol, 18 (6), 694-704
DOI 10.1038/ni.3716, PubMed 28369050

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA et al. (2017)
Metabolic gatekeeper function of B-lymphoid transcription factors
Nature, 542 (7642), 479-483
DOI 10.1038/nature21076, PubMed 28192788

Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M (2017)
Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1⁺ pre-B ALL
J Exp Med, 214 (3), 793-814
DOI 10.1084/jem.20160049, PubMed 28190001

Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L (2016)
Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway
Immunity, 45 (1), 185-97
DOI 10.1016/j.immuni.2016.06.027, PubMed 27438771

Arenzana TL, Schjerven H, Smale ST (2015)
Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor
Genes Dev, 29 (17), 1801-16
DOI 10.1101/gad.266999.115, PubMed 26314708

Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S (2015)
Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia
Blood, 126 (15), 1813-22
DOI 10.1182/blood-2015-06-651505, PubMed 26219304

Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M (2015)
Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia
Nat Commun, 6, 6471
DOI 10.1038/ncomms7471, PubMed 25753524

Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L (2014)
Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros
J Immunol, 193 (8), 3934-46
DOI 10.4049/jimmunol.1401234, PubMed 25194055

Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST (2013)
Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros
Nat Immunol, 14 (10), 1073-83
DOI 10.1038/ni.2707, PubMed 24013668

Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H (2008)
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros
Nat Immunol, 9 (8), 927-36
DOI 10.1038/ni.1626, PubMed 18568028

Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS (2005)
Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses
J Immunol, 175 (1), 376-84
DOI 10.4049/jimmunol.175.1.376, PubMed 15972671

Schjerven H, Tran TN, Brandtzaeg P, Johansen FE (2004)
De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor
J Immunol, 173 (3), 1849-57
DOI 10.4049/jimmunol.173.3.1849, PubMed 15265917

Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P (2003)
Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes
Br J Dermatol, 149 (3), 484-91
DOI 10.1046/j.1365-2133.2003.05536.x, PubMed 14510979

Schjerven H, Brandtzaeg P, Johansen FE (2003)
Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4
J Immunol, 170 (12), 6048-56
DOI 10.4049/jimmunol.170.12.6048, PubMed 12794133

Schjerven H, Brandtzaeg P, Johansen FE (2001)
A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor
J Immunol, 167 (11), 6412-20
DOI 10.4049/jimmunol.167.11.6412, PubMed 11714807

Schjerven H, Brandtzaeg P, Johansen FE (2000)
Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response
J Immunol, 165 (7), 3898-906
DOI 10.4049/jimmunol.165.7.3898, PubMed 11034397

Ertesvåg H, Høidal HK, Schjerven H, Svanem BI, Valla S (1999)
Mannuronan C-5-epimerases and their application for in vitro and in vivo design of new alginates useful in biotechnology
Metab Eng, 1 (3), 262-9
DOI 10.1006/mben.1999.0130, PubMed 10937941

van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ (1997)
E2F-mediated growth regulation requires transcription factor cooperation
J Biol Chem, 272 (29), 18367-74
DOI 10.1074/jbc.272.29.18367, PubMed 9218478

Review articles

Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S (2021)
Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia
Int J Mol Sci, 22 (5)
DOI 10.3390/ijms22052683, PubMed 33799946

Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P (1999)
Regulation of the formation and external transport of secretory immunoglobulins
Crit Rev Immunol, 19 (5-6), 481-508
PubMed 10647747

Other articles

Cosgun KN, Jumaa H, Robinson ME, Kistner KM, Xu L, Xiao G, Chan LN, Lee J, Kume K, Leveille E, Fonseca-Arce D, Khanduja D, Ng HL, Feldhahn N, Song J, Chan WC, Chen J, Taketo MM, Kothari S, Davids MS, Schjerven H, Jellusova J, Müschen M (2023)
Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies
bioRxiv
DOI 10.1101/2023.03.13.532152, PubMed 36993619

Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A (2018)
A kindred with mutant IKAROS and autoimmunity
J Allergy Clin Immunol, 142 (2), 699-702.e12
DOI 10.1016/j.jaci.2018.04.008, PubMed 29705243

Theses

Schjerven H (2003)
Transcriptional regulation of the human polymeric immunoglobulin receptor (pIgR) gene: characterization of a cytokine-responsive enhancer in intron 1
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 82, 1 b. (flere pag.)
BIBSYS 030455359, ISBN 82-8072-055-3