Publication list - Publika - Scientific publications from Oslo University Hospital

Publications by Inger Helene Madshus

68 publications found

Original articles

Sak MM, Szymanska M, Bertelsen V, Hasmann M, Madshus IH, Stang E (2013)
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3
Carcinogenesis, 34 (9), 2031-8
DOI 10.1093/carcin/bgt173, PubMed 23698633

Vuong TT, Berger C, Bertelsen V, Rødland MS, Stang E, Madshus IH (2012)
Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes
Exp Cell Res, 319 (3), 32-45
DOI 10.1016/j.yexcr.2012.10.010, PubMed 23127513

Berger C, Madshus IH, Stang E (2012)
Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis
Exp Cell Res, 318 (20), 2578-91
DOI 10.1016/j.yexcr.2012.09.001, PubMed 22975728

Hughes JB, Rødland MS, Hasmann M, Madshus IH, Stang E (2012)
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab
Pharmaceuticals (Basel), 5 (7), 674-89
DOI 10.3390/ph5070674, PubMed 24281706

Sak MM, Breen K, Rønning SB, Pedersen NM, Bertelsen V, Stang E, Madshus IH (2012)
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner
Carcinogenesis, 33 (5), 1031-9
DOI 10.1093/carcin/bgs128, PubMed 22436610

Grandal MV, Grøvdal LM, Henriksen L, Andersen MH, Holst MR, Madshus IH, van Deurs B (2012)
Differential roles of Grb2 and AP-2 in p38 MAPK- and EGF-induced EGFR internalization
Traffic, 13 (4), 576-85
DOI 10.1111/j.1600-0854.2011.01322.x, PubMed 22192528

Berger C, Krengel U, Stang E, Moreno E, Madshus IH (2011)
Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations
J Immunother, 34 (7), 550-5
DOI 10.1097/CJI.0b013e31822a5ca6, PubMed 21760527

Rønning SB, Pedersen NM, Madshus IH, Stang E (2011)
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor
Exp Cell Res, 317 (13), 1804-16
DOI 10.1016/j.yexcr.2011.05.016, PubMed 21635887

Bertelsen V, Sak MM, Breen K, Rødland MS, Johannessen LE, Traub LM, Stang E, Madshus IH (2011)
A chimeric pre-ubiquitinated EGF receptor is constitutively endocytosed in a clathrin-dependent, but kinase-independent manner
Traffic, 12 (4), 507-20
DOI 10.1111/j.1600-0854.2011.01162.x, PubMed 21226813

Madshus IH, Stang E (2009)
Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking
J Cell Sci, 122 (Pt 19), 3433-9
DOI 10.1242/jcs.050260, PubMed 19759283

Hughes JB, Berger C, Rødland MS, Hasmann M, Stang E, Madshus IH (2009)
Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization
Mol Cancer Ther, 8 (7), 1885-92
DOI 10.1158/1535-7163.MCT-09-0291, PubMed 19584234

Pedersen NM, Breen K, Rødland MS, Haslekås C, Stang E, Madshus IH (2009)
Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2
Mol Cancer Res, 7 (2), 275-84
DOI 10.1158/1541-7786.MCR-07-2183, PubMed 19208749

Kazazic M, Bertelsen V, Pedersen KW, Vuong TT, Grandal MV, Rødland MS, Traub LM, Stang E, Madshus IH (2008)
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits
Traffic, 10 (2), 235-45
DOI 10.1111/j.1600-0854.2008.00858.x, PubMed 19054389

Pedersen NM, Madshus IH, Haslekås C, Stang E (2008)
Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent
Mol Cancer Res, 6 (3), 491-500
DOI 10.1158/1541-7786.MCR-07-0191, PubMed 18337455

Grøvdal LM, Johannessen LE, Rødland MS, Madshus IH, Stang E (2008)
Dysregulation of Ack1 inhibits down-regulation of the EGF receptor
Exp Cell Res, 314 (6), 1292-300
DOI 10.1016/j.yexcr.2007.12.017, PubMed 18262180

Bertelsen V, Breen K, Sandvig K, Stang E, Madshus IH (2007)
The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis
Exp Cell Res, 313 (8), 1696-709
DOI 10.1016/j.yexcr.2007.02.017, PubMed 17382318

Kazazic M, Roepstorff K, Johannessen LE, Pedersen NM, van Deurs B, Stang E, Madshus IH (2006)
EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae
Traffic, 7 (11), 1518-27
DOI 10.1111/j.1600-0854.2006.00487.x, PubMed 16984407

Myromslien FD, Grøvdal LM, Raiborg C, Stenmark H, Madshus IH, Stang E (2006)
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Exp Cell Res, 312 (16), 3036-48
DOI 10.1016/j.yexcr.2006.06.004, PubMed 16859684

Johannessen LE, Pedersen NM, Pedersen KW, Madshus IH, Stang E (2006)
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits
Mol Cell Biol, 26 (2), 389-401
DOI 10.1128/MCB.26.2.389-401.2006, PubMed 16382132

Haslekås C, Breen K, Pedersen KW, Johannessen LE, Stang E, Madshus IH (2005)
The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane
Mol Biol Cell, 16 (12), 5832-42
DOI 10.1091/mbc.e05-05-0456, PubMed 16207817

Longva KE, Pedersen NM, Haslekås C, Stang E, Madshus IH (2005)
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2
Int J Cancer, 116 (3), 359-67
DOI 10.1002/ijc.21015, PubMed 15800944

Grøvdal LM, Stang E, Sorkin A, Madshus IH (2004)
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation
Exp Cell Res, 300 (2), 388-95
DOI 10.1016/j.yexcr.2004.07.003, PubMed 15475003

Stang E, Blystad FD, Kazazic M, Bertelsen V, Brodahl T, Raiborg C, Stenmark H, Madshus IH (2004)
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits
Mol Biol Cell, 15 (8), 3591-604
DOI 10.1091/mbc.e04-01-0041, PubMed 15194809

Normann AP, Egeland T, Madshus IH, Heim S, Tjønnfjord GE (2003)
CD7 expression by CD34+ cells in CML patients, of prognostic significance?
Eur J Haematol, 71 (4), 266-75
DOI 10.1034/j.1600-0609.2003.00133.x, PubMed 12950236

Bache KG, Raiborg C, Mehlum A, Madshus IH, Stenmark H (2002)
Phosphorylation of Hrs downstream of the epidermal growth factor receptor
Eur J Biochem, 269 (16), 3881-7
DOI 10.1046/j.1432-1033.2002.03046.x, PubMed 12180964

Raiborg C, Bache KG, Gillooly DJ, Madshus IH, Stang E, Stenmark H (2002)
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
Nat Cell Biol, 4 (5), 394-8
DOI 10.1038/ncb791, PubMed 11988743

Ringerike T, Blystad FD, Levy FO, Madshus IH, Stang E (2002)
Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae
J Cell Sci, 115 (Pt 6), 1331-40
DOI 10.1242/jcs.115.6.1331, PubMed 11884532

Longva KE, Blystad FD, Stang E, Larsen AM, Johannessen LE, Madshus IH (2002)
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
J Cell Biol, 156 (5), 843-54
DOI 10.1083/jcb.200106056, PubMed 11864992

Johannessen LE, Haugen KE, østvold AC, Stang E, Madshus IH (2001)
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms
Biochem J, 356 (Pt 1), 87-96
DOI 10.1042/0264-6021:3560087, PubMed 11336639

Johannessen LE, Ringerike T, Molnes J, Madshus IH (2000)
Epidermal growth factor receptor efficiently activates mitogen-activated protein kinase in HeLa cells and Hep2 cells conditionally defective in clathrin-dependent endocytosis
Exp Cell Res, 260 (1), 136-45
DOI 10.1006/excr.2000.5004, PubMed 11010818

Stang E, Johannessen LE, Knardal SL, Madshus IH (2000)
Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation
J Biol Chem, 275 (18), 13940-7
DOI 10.1074/jbc.275.18.13940, PubMed 10788520

Johannessen LE, Knardal SL, Madshus IH (1999)
Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein
Biochem J, 337 ( Pt 3) (Pt 3), 599-606
DOI 10.1042/0264-6021:3370599, PubMed 9895307

Lindeman B, Skarpen E, Thoresen GH, Christoffersen T, Wierød L, Madshus IH, Huitfeldt HS (1999)
Alteration of G1 cell-cycle protein expression and induction of p53 but not p21/waf1 by the DNA-modifying carcinogen 2-acetylaminofluorene in growth-stimulated hepatocytes in vitro
Mol Carcinog, 24 (1), 36-46
DOI 10.1002/(sici)1098-2744(199901)24:1<36::aid-mc6>3.0.co;2-i, PubMed 10029409

Nogva HK, Evensen SA, Madshus IH (1998)
One-tube multiplex RT-PCR of BCR-ABL transcripts in analysis of patients with chronic myeloid leukaemia and acute lymphoblastic leukaemia
Scand J Clin Lab Invest, 58 (8), 647-54
DOI 10.1080/00365519850186076, PubMed 10088201

Skarpen E, Johannessen LE, Bjerk K, Fasteng H, Guren TK, Lindeman B, Thoresen GH, Christoffersen T, Stang E, Huitfeldt HS, Madshus IH (1998)
Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1
Exp Cell Res, 243 (1), 161-72
DOI 10.1006/excr.1998.4127, PubMed 9716460

Ringerike T, Stang E, Johannessen LE, Sandnes D, Levy FO, Madshus IH (1998)
High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A)
J Biol Chem, 273 (27), 16639-42
DOI 10.1074/jbc.273.27.16639, PubMed 9642213

Madshus IH (1995)
Diphtheria toxin can be used as a vehicle for bringing other proteins into cells
Restor Neurol Neurosci, 8 (1), 13-4
DOI 10.3233/RNN-1995-81204, PubMed 21551798

Madshus IH (1994)
The N-terminal alpha-helix of fragment B of diphtheria toxin promotes translocation of fragment A into the cytoplasm of eukaryotic cells
J Biol Chem, 269 (26), 17723-9
PubMed 8021285

Wiedłocha A, Falnes PO, Madshus IH, Sandvig K, Olsnes S (1994)
Dual mode of signal transduction by externally added acidic fibroblast growth factor
Cell, 76 (6), 1039-51
DOI 10.1016/0092-8674(94)90381-6, PubMed 7511061

Falnes PO, Choe S, Madshus IH, Wilson BA, Olsnes S (1994)
Inhibition of membrane translocation of diphtheria toxin A-fragment by internal disulfide bridges
J Biol Chem, 269 (11), 8402-7
PubMed 8132565

Madshus IH, Wiedlocha A, Sandvig K (1994)
Intermediates in translocation of diphtheria toxin across the plasma membrane
J Biol Chem, 269 (6), 4648-52
PubMed 7508447

Esbensen QY, Falnes PO, Olsnes S, Madshus IH (1993)
Subcloning and characterization of the binding domain of fragment B of diphtheria toxin
Biochem J, 294 ( Pt 3) (Pt 3), 663-6
DOI 10.1042/bj2940663, PubMed 8379922

Ariansen S, Afanasiev BN, Moskaug JO, Stenmark H, Madshus IH, Olsnes S (1993)
Membrane translocation of diphtheria toxin A-fragment: role of carboxy-terminal region
Biochemistry, 32 (1), 83-90
DOI 10.1021/bi00052a012, PubMed 8418864

Wiedlocha A, Madshus IH, Mach H, Middaugh CR, Olsnes S (1992)
Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector
EMBO J, 11 (13), 4835-42
DOI 10.1002/j.1460-2075.1992.tb05589.x, PubMed 1281450

Madshus IH, Olsnes S, Stenmark H (1992)
Membrane translocation of diphtheria toxin carrying passenger protein domains
Infect Immun, 60 (8), 3296-302
DOI 10.1128/iai.60.8.3296-3302.1992, PubMed 1639497

Falnes PO, Madshus IH, Sandvig K, Olsnes S (1992)
Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment. Effect on membrane translocation and on formation of cation channels
J Biol Chem, 267 (17), 12284-90
PubMed 1376320

Madshus IH, Stenmark H, Sandvig K, Olsnes S (1991)
Entry of diphtheria toxin-protein A chimeras into cells
J Biol Chem, 266 (26), 17446-53
PubMed 1894632

Stenmark H, Moskaug JO, Madshus IH, Sandvig K, Olsnes S (1991)
Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol
J Cell Biol, 113 (5), 1025-32
DOI 10.1083/jcb.113.5.1025, PubMed 2040642

Stenmark H, Olsnes S, Madshus IH (1991)
Elimination of the disulphide bridge in fragment B of diphtheria toxin: effect on membrane insertion, channel formation, and ATP binding
Mol Microbiol, 5 (3), 595-606
DOI 10.1111/j.1365-2958.1991.tb00730.x, PubMed 1646374

Madshus IH, Collier RJ (1989)
Effects of eliminating a disulfide bridge within domain II of Pseudomonas aeruginosa exotoxin A
Infect Immun, 57 (7), 1873-8
DOI 10.1128/iai.57.7.1873-1878.1989, PubMed 2499539

Madshus IH, Olsnes S (1987)
Selective inhibition of sodium-linked and sodium-independent bicarbonate/chloride antiport in Vero cells
J Biol Chem, 262 (16), 7486-91
PubMed 3584123

Aarnes CM, Madshus IH, Guillemot JC, Sandvig K, Olsnes S (1987)
Formation and activity of covalent conjugates of poliovirus and ligands binding to cell surface structures
Exp Cell Res, 170 (2), 483-90
DOI 10.1016/0014-4827(87)90322-3, PubMed 3036553

Madshus IH, Sandvig K, Olsnes S, van Deurs B (1987)
Effect of reduced endocytosis induced by hypotonic shock and potassium depletion on the infection of Hep 2 cells by picornaviruses
J Cell Physiol, 131 (1), 14-22
DOI 10.1002/jcp.1041310104, PubMed 3032992

Madshus IH, Tønnessen TI, Olsnes S, Sandvig K (1987)
Effect of potassium depletion of Hep 2 cells on intracellular pH and on chloride uptake by anion antiport
J Cell Physiol, 131 (1), 6-13
DOI 10.1002/jcp.1041310103, PubMed 3571337

Madshus IH, Olsnes S, Sandvig K (1984)
Different pH requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus
Virology, 139 (2), 346-57
DOI 10.1016/0042-6822(84)90380-5, PubMed 6097029

Madshus IH, Olsnes S, Sandvig K (1984)
Requirements for entry of poliovirus RNA into cells at low pH
EMBO J, 3 (9), 1945-50
DOI 10.1002/j.1460-2075.1984.tb02074.x, PubMed 6092049

Sandvig K, Madshus IH, Olsnes S (1984)
Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus
Biochem J, 219 (3), 935-40
DOI 10.1042/bj2190935, PubMed 6331401

Madshus IH, Olsnes S, Sandvig K (1984)
Mechanism of entry into the cytosol of poliovirus type 1: requirement for low pH
J Cell Biol, 98 (4), 1194-200
DOI 10.1083/jcb.98.4.1194, PubMed 6325467

Review articles

Grandal MV, Madshus IH (2008)
Epidermal growth factor receptor and cancer: control of oncogenic signalling by endocytosis
J Cell Mol Med, 12 (5A), 1527-34
DOI 10.1111/j.1582-4934.2008.00298.x, PubMed 18318691

Madshus IH, Stenmark H (1992)
Entry of ADP-ribosylating toxins into cells
Curr Top Microbiol Immunol, 175, 1-26
DOI 10.1007/978-3-642-76966-5_1, PubMed 1378368

Olsnes S, Stenmark H, Moskaug JO, McGill S, Madshus IH, Sandvig K (1990)
Protein toxins with intracellular targets
Microb Pathog, 8 (3), 163-8
DOI 10.1016/0882-4010(90)90043-p, PubMed 1696341

Madshus IH (1988)
Regulation of intracellular pH in eukaryotic cells
Biochem J, 250 (1), 1-8
DOI 10.1042/bj2500001, PubMed 2965576

Olsnes S, Sandvig K, Madshus IH, Sundan A (1985)
Entry mechanisms of protein toxins and picornaviruses
Biochem Soc Symp, 50, 171-91
PubMed 3915869