Publication list - Publika - Scientific publications from Oslo University Hospital

Publications by Randi G. Syljuåsen

57 publications found

Original articles

Eek Mariampillai A, Hauge S, Kongsrud K, Syljuåsen RG (2023)
Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases
Front Immunol, 14, 1138920
DOI 10.3389/fimmu.2023.1138920, PubMed 37346039

Bay LTE, Stokke T, Syljuåsen RG, Landsverk HB (2023)
Analysis of RNA Polymerase II Chromatin Binding by Flow Cytometry
Bio Protoc, 13 (8), e4659
DOI 10.21769/BioProtoc.4659, PubMed 37113330

Eek Mariampillai A, Hauge S, Øynebråten I, Rødland GE, Corthay A, Syljuåsen RG (2022)
Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells
Front Oncol, 12, 981332
DOI 10.3389/fonc.2022.981332, PubMed 36387237

Bay LTE, Syljuåsen RG, Landsverk HB (2022)
A novel, rapid and sensitive flow cytometry method reveals degradation of promoter proximal paused RNAPII in the presence and absence of UV
Nucleic Acids Res, 50 (15), e89
DOI 10.1093/nar/gkac434, PubMed 35641102

Rødland GE, Hauge S, Hasvold G, Bay LTE, Raabe TTH, Joel M, Syljuåsen RG (2021)
Differential Effects of Combined ATR/WEE1 Inhibition in Cancer Cells
Cancers (Basel), 13 (15)
DOI 10.3390/cancers13153790, PubMed 34359691

Landsverk HB, Sandquist LE, Bay LTE, Syljuåsen RG (2021)
New link between the RNA polymerase II-CTD and replication stress
Mol Cell Oncol, 8 (3), 1910008
DOI 10.1080/23723556.2021.1910008, PubMed 34027044

Landsverk HB, Sandquist LE, Bay LTE, Steurer B, Campsteijn C, Landsverk OJB, Marteijn JA, Petermann E, Trinkle-Mulcahy L, Syljuåsen RG (2020)
WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin
Cell Rep, 33 (9), 108469
DOI 10.1016/j.celrep.2020.108469, PubMed 33264625

Rødland GE, Melhus K, Generalov R, Gilani S, Bertoni F, Dahle J, Syljuåsen RG, Patzke S (2019)
The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37-Targeted Radioimmunotherapy in Activated B Cell Like Diffuse Large B Cell Lymphoma Cell Lines
Front Oncol, 9, 1301
DOI 10.3389/fonc.2019.01301, PubMed 31850205

Hauge S, Macurek L, Syljuåsen RG (2019)
p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775
Cell Cycle, 18 (8), 834-847
DOI 10.1080/15384101.2019.1593649, PubMed 30943845

Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG (2019)
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
Nucleic Acids Res, 47 (4), 1797-1813
DOI 10.1093/nar/gky1233, PubMed 30541148

Bøe CA, Håland TW, Boye E, Syljuåsen RG, Grallert B (2018)
A novel role for ATR/Rad3 in G1 phase
Sci Rep, 8 (1), 6880
DOI 10.1038/s41598-018-25238-6, PubMed 29720710

Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevær RL, Aukrust P, Fevang B, Blomhoff HK (2017)
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
PLoS One, 12 (10), e0185708
DOI 10.1371/journal.pone.0185708, PubMed 28973009

Hauge S, Naucke C, Hasvold G, Joel M, Rødland GE, Juzenas P, Stokke T, Syljuåsen RG (2017)
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
Oncotarget, 8 (7), 10966-10979
DOI 10.18632/oncotarget.14089, PubMed 28030798

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2017)
Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 8 (4), 7208-7213
DOI 10.18632/oncotarget.14800, PubMed 28179591

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2016)
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 7 (26), 40297-40313
DOI 10.18632/oncotarget.9610, PubMed 27248169

Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG (2016)
Hypoxia-induced alterations of G2 checkpoint regulators
Mol Oncol, 10 (5), 764-73
DOI 10.1016/j.molonc.2015.12.015, PubMed 26791779

Håland TW, Boye E, Stokke T, Grallert B, Syljuåsen RG (2015)
Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Nucleic Acids Res, 43 (22), e150
DOI 10.1093/nar/gkv744, PubMed 26250117

Halvorsen AR, Helland A, Fleischer T, Haug KM, Grenaker Alnaes GI, Nebdal D, Syljuåsen RG, Touleimat N, Busato F, Tost J, Saetersdal AB, Børresen-Dale AL, Kristensen V, Edvardsen H (2014)
Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy
Int J Cancer, 135 (9), 2085-95
DOI 10.1002/ijc.28862, PubMed 24658971

Lund-Andersen C, Patzke S, Nähse-Kumpf V, Syljuåsen RG (2014)
PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule
Radiother Oncol, 110 (2), 355-61
DOI 10.1016/j.radonc.2013.12.014, PubMed 24502970

Hasvold G, Nähse-Kumpf V, Tkacz-Stachowska K, Rofstad EK, Syljuåsen RG (2013)
The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation
Mol Cancer Ther, 12 (5), 705-16
DOI 10.1158/1535-7163.MCT-12-0879, PubMed 23635654

Beck H, Nähse-Kumpf V, Larsen MS, O'Hanlon KA, Patzke S, Holmberg C, Mejlvang J, Groth A, Nielsen O, Syljuåsen RG, Sørensen CS (2012)
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
Mol Cell Biol, 32 (20), 4226-36
DOI 10.1128/MCB.00412-12, PubMed 22907750

Halle C, Andersen E, Lando M, Aarnes EK, Hasvold G, Holden M, Syljuåsen RG, Sundfør K, Kristensen GB, Holm R, Malinen E, Lyng H (2012)
Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI
Cancer Res, 72 (20), 5285-95
DOI 10.1158/0008-5472.CAN-12-1085, PubMed 22890239

Sørensen CS, Syljuåsen RG (2011)
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
Nucleic Acids Res, 40 (2), 477-86
DOI 10.1093/nar/gkr697, PubMed 21937510

Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS (2011)
A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
EMBO Rep, 12 (7), 705-12
DOI 10.1038/embor.2011.99, PubMed 21637299

Tkacz-Stachowska K, Lund-Andersen C, Velissarou A, Myklebust JH, Stokke T, Syljuåsen RG (2011)
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells
Radiother Oncol, 101 (1), 24-7
DOI 10.1016/j.radonc.2011.05.060, PubMed 21722983

Küntziger T, Landsverk HB, Collas P, Syljuåsen RG (2011)
Protein phosphatase 1 regulators in DNA damage signaling
Cell Cycle, 10 (9), 1356-62
DOI 10.4161/cc.10.9.15442, PubMed 21451260

Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS (2011)
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
J Cell Biol, 192 (1), 43-54
DOI 10.1083/jcb.201009076, PubMed 21220508

Landsverk HB, Mora-Bermúdez F, Landsverk OJ, Hasvold G, Naderi S, Bakke O, Ellenberg J, Collas P, Syljuåsen RG, Küntziger T (2010)
The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response
EMBO Rep, 11 (11), 868-75
DOI 10.1038/embor.2010.134, PubMed 20890310

Petersen L, Hasvold G, Lukas J, Bartek J, Syljuåsen RG (2010)
p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors
Cell Prolif, 43 (4), 365-71
DOI 10.1111/j.1365-2184.2010.00685.x, PubMed 20590661

Beck H, Nähse V, Larsen MS, Groth P, Clancy T, Lees M, Jørgensen M, Helleday T, Syljuåsen RG, Sørensen CS (2010)
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
J Cell Biol, 188 (5), 629-38
DOI 10.1083/jcb.200905059, PubMed 20194642

Syljuåsen RG, Jensen S, Bartek J, Lukas J (2006)
Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases
Cancer Res, 66 (21), 10253-7
DOI 10.1158/0008-5472.CAN-06-2144, PubMed 17079442

Syljuåsen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J (2005)
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
Mol Cell Biol, 25 (9), 3553-62
DOI 10.1128/MCB.25.9.3553-3562.2005, PubMed 15831461

Sørensen CS, Hansen LT, Dziegielewski J, Syljuåsen RG, Lundin C, Bartek J, Helleday T (2005)
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Nat Cell Biol, 7 (2), 195-201
DOI 10.1038/ncb1212, PubMed 15665856

Syljuåsen RG, Sørensen CS, Nylandsted J, Lukas C, Lukas J, Bartek J (2004)
Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation
Cancer Res, 64 (24), 9035-40
DOI 10.1158/0008-5472.CAN-04-2434, PubMed 15604269

Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J (2004)
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Nat Cell Biol, 6 (9), 884-91
DOI 10.1038/ncb1165, PubMed 15311285

Sørensen CS, Syljuåsen RG, Lukas J, Bartek J (2004)
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
Cell Cycle, 3 (7), 941-5
PubMed 15190204

Löffler H, Syljuåsen RG, Bartkova J, Worm J, Lukas J, Bartek J (2003)
Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines
Oncogene, 22 (50), 8063-71
DOI 10.1038/sj.onc.1206976, PubMed 14603247

Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J (2003)
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
Cancer Cell, 3 (3), 247-58
DOI 10.1016/s1535-6108(03)00048-5, PubMed 12676583

Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK (2003)
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
J Biol Chem, 278 (17), 14806-11
DOI 10.1074/jbc.M210862200, PubMed 12588868

Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J (2001)
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
Nature, 410 (6830), 842-7
DOI 10.1038/35071124, PubMed 11298456

Syljuåsen RG, Krolewski B, Little JB (2001)
Molecular events in radiation transformation
Radiat Res, 155 (1 Pt 2), 215-221
DOI 10.1667/0033-7587(2001)155[0215:meirt]2.0.co;2, PubMed 11121237

Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, Bartek J, Lukas J (2000)
Rapid destruction of human Cdc25A in response to DNA damage
Science, 288 (5470), 1425-9
DOI 10.1126/science.288.5470.1425, PubMed 10827953

Whang YE, Tran C, Henderson C, Syljuasen RG, Rozengurt N, McBride WH, Sawyers CL (2000)
c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency
Proc Natl Acad Sci U S A, 97 (10), 5486-91
DOI 10.1073/pnas.97.10.5486, PubMed 10805805

Syljuâsen RG, McBride WH (1999)
Radiation-induced apoptosis and cell cycle progression in Jurkat T cells
Radiat Res, 152 (3), 328-31
PubMed 10453094

Syljuåsen RG, Krolewski B, Little JB (1999)
Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53 status
Cancer Res, 59 (5), 1008-14
PubMed 10070956

Syljuåsen RG, Belldegrun A, Tso CL, Withers HR, McBride WH (1997)
Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection
Radiat Res, 148 (5), 443-8
PubMed 9355869

Chiang CS, Syljuäsen RG, Hong JH, Wallis A, Dougherty GJ, McBride WH (1997)
Effects of IL-3 gene expression on tumor response to irradiation in vitro and in vivo
Cancer Res, 57 (18), 3899-903
PubMed 9307268

Syljuåsen RG, Hong JH, McBride WH (1996)
Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells
Radiat Res, 146 (3), 276-82
PubMed 8752305

McBride WH, Economou JS, Kuber N, Hong JH, Chiang CS, Syljuasen R, Dougherty ST, Dougherty GJ (1995)
Modification of tumor microenvironment by cytokine gene transfer
Acta Oncol, 34 (3), 447-51
DOI 10.3109/02841869509094007, PubMed 7779438

GUSSGARD R, LINDMO T, BREVIK I (1992)
CALCULATION OF THE TRAPPING FORCE IN A STRONGLY FOCUSED LASER-BEAM
J. Opt. Soc. Am. B-Opt. Phys., 9 (10), 1922-1930
DOI 10.1364/JOSAB.9.001922

Review articles

Hauge S, Eek Mariampillai A, Rødland GE, Bay LTE, Landsverk HB, Syljuåsen RG (2021)
Expanding roles of cell cycle checkpoint inhibitors in radiation oncology
Int J Radiat Biol, 99 (6), 941-950
DOI 10.1080/09553002.2021.1913529, PubMed 33877959

Syljuåsen RG, Hasvold G, Hauge S, Helland Å (2015)
Targeting lung cancer through inhibition of checkpoint kinases
Front Genet, 6, 70
DOI 10.3389/fgene.2015.00070, PubMed 25774168

Syljuåsen RG (2007)
Checkpoint adaptation in human cells
Oncogene, 26 (40), 5833-9
DOI 10.1038/sj.onc.1210402, PubMed 17384683

McBride WH, Iwamoto KS, Syljuasen R, Pervan M, Pajonk F (2003)
The role of the ubiquitin/proteasome system in cellular responses to radiation
Oncogene, 22 (37), 5755-73
DOI 10.1038/sj.onc.1206676, PubMed 12947384

McBride WH, Economou JS, Syljuåsen RG, Parrish C, Hackman D, Latham V, Chiang CS, Dougherty GJ (1996)
The effects of cytokine gene transfer into tumors on host cell infiltration and regression
Anticancer Res, 16 (3A), 1139-43
PubMed 8702225