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Publications by Kurt A. Krobert

49 publications found

Original articles

Levay MK, Krobert KA, Vogt A, Ahmad A, Jungmann A, Neuber C, Pasch S, Hansen A, Müller OJ, Lutz S, Wieland T (2022)
RGS3L allows for an M₂ muscarinic receptor-mediated RhoA-dependent inotropy in cardiomyocytes
Basic Res Cardiol, 117 (1), 8
DOI 10.1007/s00395-022-00915-w, PubMed 35230541

Bull Melsom C, Cosson MV, Ørstavik Ø, Lai NC, Hammond HK, Osnes JB, Skomedal T, Nikolaev V, Levy FO, Krobert KA (2019)
Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
PLoS One, 14 (6), e0218110
DOI 10.1371/journal.pone.0218110, PubMed 31173603

Cosson MV, Hiis HG, Moltzau LR, Levy FO, Krobert KA (2019)
Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β₁-adrenoceptor-mediated inotropic response
J Mol Cell Cardiol, 131, 132-145
DOI 10.1016/j.yjmcc.2019.04.017, PubMed 31009605

Hiis HG, Cosson MV, Dahl CP, Fiane AE, Levy FO, Andersen GØ, Krobert KA (2018)
Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole
Am J Physiol Heart Circ Physiol, 315 (5), H1137-H1147
DOI 10.1152/ajpheart.00208.2018, PubMed 30004809

Andressen KW, Ulsund AH, Krobert KA, Lohse MJ, Bünemann M, Levy FO (2018)
Related GPCRs couple differently to G_s: preassociation between G protein and 5-HT₇ serotonin receptor reveals movement of Gα_s upon receptor activation
FASEB J, 32 (2), 1059-1069
DOI 10.1096/fj.201700486R, PubMed 29079700

Braadland PR, Grytli HH, Ramberg H, Katz B, Kellman R, Gauthier-Landry L, Fazli L, Krobert KA, Wang W, Levy FO, Bjartell A, Berge V, Rennie PS, Mellgren G, Mælandsmo GM, Svindland A, Barbier O, Taskén KA (2016)
Low β₂-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism
Oncotarget, 7 (2), 1878-94
DOI 10.18632/oncotarget.6479, PubMed 26646591

Andressen KW, Manfra O, Brevik CH, Ulsund AH, Vanhoenacker P, Levy FO, Krobert KA (2015)
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors
Br J Pharmacol, 172 (15), 3846-60
DOI 10.1111/bph.13169, PubMed 25884989

Impellizzeri AA, Pappalardo M, Basile L, Manfra O, Andressen KW, Krobert KA, Messina A, Levy FO, Guccione S (2015)
Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis
Front Behav Neurosci, 9, 92
DOI 10.3389/fnbeh.2015.00092, PubMed 26005408

Ørstavik Ø, Manfra O, Andressen KW, Andersen GØ, Skomedal T, Osnes JB, Levy FO, Krobert KA (2015)
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium
PLoS One, 10 (3), e0115547
DOI 10.1371/journal.pone.0115547, PubMed 25738589

Melsom CB, Hussain RI, Ørstavik Ø, Aronsen JM, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Krobert KA (2014)
Non-classical regulation of β1- and β 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi
Naunyn Schmiedebergs Arch Pharmacol, 387 (12), 1177-86
DOI 10.1007/s00210-014-1036-7, PubMed 25216690

Melsom CB, Ørstavik Ø, Osnes JB, Skomedal T, Levy FO, Krobert KA (2014)
Gi proteins regulate adenylyl cyclase activity independent of receptor activation
PLoS One, 9 (9), e106608
DOI 10.1371/journal.pone.0106608, PubMed 25203113

Levay M, Krobert KA, Wittig K, Voigt N, Bermudez M, Wolber G, Dobrev D, Levy FO, Wieland T (2013)
NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors
J Pharmacol Exp Ther, 347 (1), 69-79
DOI 10.1124/jpet.113.207266, PubMed 23887096

Gravning J, Ahmed MS, Qvigstad E, Krobert K, Edvardsen T, Moe IT, Hagelin EM, Sagave J, Valen G, Levy FO, Osnes JB, Skomedal T, Attramadal H (2013)
Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes
Mol Pharmacol, 84 (3), 372-83
DOI 10.1124/mol.113.087312, PubMed 23778361

Molenaar P, Christ T, Hussain RI, Engel A, Berk E, Gillette KT, Chen L, Galindo-Tovar A, Krobert KA, Ravens U, Levy FO, Kaumann AJ (2013)
PDE3, but not PDE4, reduces β₁ - and β₂-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients
Br J Pharmacol, 169 (3), 528-38
DOI 10.1111/bph.12167, PubMed 23489141

Hussain RI, Aronsen JM, Afzal F, Sjaastad I, Osnes JB, Skomedal T, Levy FO, Krobert KA (2012)
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle
J Mol Cell Cardiol, 56, 129-38
DOI 10.1016/j.yjmcc.2012.11.015, PubMed 23220156

Riise J, Ørstavik Ø, Qvigstad E, Dahl CP, Osnes JB, Skomedal T, Levy FO, Krobert KA (2012)
Prostaglandin E1 facilitates inotropic effects of 5-HT4 serotonin receptors and β-adrenoceptors in failing human heart
Basic Res Cardiol, 107 (5), 295
DOI 10.1007/s00395-012-0295-z, PubMed 22923058

von Lueder TG, Gravning J, How OJ, Vinge LE, Ahmed MS, Krobert KA, Levy FO, Larsen TS, Smiseth OA, Aasum E, Attramadal H (2012)
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
Am J Physiol Heart Circ Physiol, 303 (1), H66-74
DOI 10.1152/ajpheart.00724.2011, PubMed 22542621

Riise J, Nguyen CH, Hussain RI, Dahl CP, Ege MS, Osnes JB, Skomedal T, Sandnes DL, Levy FO, Krobert KA (2012)
Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium
Eur J Pharmacol, 686 (1-3), 66-73
DOI 10.1016/j.ejphar.2012.04.022, PubMed 22546232

Hussain RI, Afzal F, Mørk HK, Aronsen JM, Sjaastad I, Osnes JB, Skomedal T, Levy FO, Krobert KA (2011)
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle
Br J Pharmacol, 162 (4), 908-16
DOI 10.1111/j.1476-5381.2010.01097.x, PubMed 21039419

Brudeli B, Moltzau LR, Andressen KW, Krobert KA, Klaveness J, Levy FO (2010)
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists
Bioorg Med Chem, 18 (24), 8600-13
DOI 10.1016/j.bmc.2010.10.011, PubMed 21075638

Hussain RI, Qvigstad E, Birkeland JA, Eikemo H, Glende A, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Krobert KA (2009)
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation
Br J Pharmacol, 156 (4), 575-86
DOI 10.1111/j.1750-3639.2009.00016.x, PubMed 19159405

Riise J, Nguyen CH, Qvigstad E, Sandnes DL, Osnes JB, Skomedal T, Levy FO, Krobert KA (2008)
Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation
Cardiovasc Res, 80 (3), 407-15
DOI 10.1093/cvr/cvn216, PubMed 18703533

Levy FO, Qvigstad E, Krobert KA, Skomedal T, Osnes JB (2008)
Effects of serotonin in failing cardiac ventricle: signalling mechanisms and potential therapeutic implications
Neuropharmacology, 55 (6), 1066-71
DOI 10.1016/j.neuropharm.2008.07.010, PubMed 18675829

Larsen KO, Lygren B, Sjaastad I, Krobert KA, Arnkvaern K, Florholmen G, Larsen AK, Levy FO, Taskén K, Skjønsberg OH, Christensen G (2008)
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A
Cardiovasc Res, 80 (1), 47-54
DOI 10.1093/cvr/cvn180, PubMed 18599478

Ramberg H, Eide T, Krobert KA, Levy FO, Dizeyi N, Bjartell AS, Abrahamsson PA, Taskén KA (2008)
Hormonal regulation of beta2-adrenergic receptor level in prostate cancer
Prostate, 68 (10), 1133-42
DOI 10.1002/pros.20778, PubMed 18454446

Brattelid T, Qvigstad E, Birkeland JA, Swift F, Bekkevold SV, Krobert KA, Sejersted OM, Skomedal T, Osnes JB, Levy FO, Sjaastad I (2007)
Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
J Mol Cell Cardiol, 43 (6), 767-79
DOI 10.1016/j.yjmcc.2007.08.019, PubMed 17936780

Brattelid T, Tveit K, Birkeland JA, Sjaastad I, Qvigstad E, Krobert KA, Hussain RI, Skomedal T, Osnes JB, Levy FO (2007)
Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure--a quantitative RT-PCR study and the question of normalisation
Basic Res Cardiol, 102 (3), 198-208
DOI 10.1007/s00395-007-0648-1, PubMed 17370034

Birkeland JA, Sjaastad I, Brattelid T, Qvigstad E, Moberg ER, Krobert KA, Bjørnerheim R, Skomedal T, Sejersted OM, Osnes JB, Levy FO (2006)
Effects of treatment with a 5-HT4 receptor antagonist in heart failure
Br J Pharmacol, 150 (2), 143-52
DOI 10.1038/sj.bjp.0706966, PubMed 17160012

Larsen KO, Sjaastad I, Svindland A, Krobert KA, Skjønsberg OH, Christensen G (2006)
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice
Am J Physiol Heart Circ Physiol, 291 (2), H507-16
DOI 10.1152/ajpheart.00862.2005, PubMed 16582020

Krobert KA, Andressen KW, Levy FO (2006)
Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT(7) serotonin receptor
Eur J Pharmacol, 532 (1-2), 1-10
DOI 10.1016/j.ejphar.2005.11.039, PubMed 16487959

Andressen KW, Norum JH, Levy FO, Krobert KA (2005)
Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression
Mol Pharmacol, 69 (1), 207-15
DOI 10.1124/mol.105.015396, PubMed 16189297

Qvigstad E, Sjaastad I, Brattelid T, Nunn C, Swift F, Birkeland JA, Krobert KA, Andersen GØ, Sejersted OM, Osnes JB, Levy FO, Skomedal T (2005)
Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart
Circ Res, 97 (3), 268-76
DOI 10.1161/01.RES.0000176970.22603.8d, PubMed 16002744

Krobert KA, Brattelid T, Levy FO, Kaumann AJ (2005)
Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants
Naunyn Schmiedebergs Arch Pharmacol, 371 (6), 473-9
DOI 10.1007/s00210-005-1068-0, PubMed 16012870

Qvigstad E, Brattelid T, Sjaastad I, Andressen KW, Krobert KA, Birkeland JA, Sejersted OM, Kaumann AJ, Skomedal T, Osnes JB, Levy FO (2005)
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure
Cardiovasc Res, 65 (4), 869-78
DOI 10.1016/j.cardiores.2004.11.017, PubMed 15721867

Øie E, Vinge LE, Andersen GØ, Yndestad A, Krobert KA, Sandberg C, Ahmed MS, Haug T, Levy FO, Skomedal T, Attramadal H (2004)
RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin
J Mol Cell Cardiol, 38 (1), 145-51
DOI 10.1016/j.yjmcc.2004.10.009, PubMed 15623431

Brattelid T, Kvingedal AM, Krobert KA, Andressen KW, Bach T, Hystad ME, Kaumann AJ, Levy FO (2004)
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
Naunyn Schmiedebergs Arch Pharmacol, 369 (6), 616-28
DOI 10.1007/s00210-004-0919-4, PubMed 15118808

Bruheim S, Krobert KA, Andressen KW, Levy FO (2003)
Unaltered agonist potency upon inducible 5-HT7(a) but not 5-HT4(b) receptor expression indicates agonist-independent association of 5-HT7(a) receptor and Gs
Recept Channels, 9 (2), 107-16
DOI 10.1080/10606820308245, PubMed 12916471

Krobert KA, Levy FO (2002)
The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects
Br J Pharmacol, 135 (6), 1563-71
DOI 10.1038/sj.bjp.0704588, PubMed 11906971

Krobert KA, Bach T, Syversveen T, Kvingedal AM, Levy FO (2001)
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution
Naunyn Schmiedebergs Arch Pharmacol, 363 (6), 620-32
DOI 10.1007/s002100000369, PubMed 11414657

Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO (2001)
5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle
Naunyn Schmiedebergs Arch Pharmacol, 363 (2), 146-60
DOI 10.1007/s002100000299, PubMed 11218067

Moser EI, Krobert KA, Moser MB, Morris RG (1998)
Impaired spatial learning after saturation of long-term potentiation
Science, 281 (5385), 2038-42
DOI 10.1126/science.281.5385.2038, PubMed 9748165

Krobert K, Lopez-Colberg I, Cunningham LA (1997)
Astrocytes promote or impair the survival and function of embryonic ventral mesencephalon co-grafts: effects of astrocyte age and expression of recombinant brain-derived neurotrophic factor
Exp Neurol, 145 (2 Pt 1), 511-23
DOI 10.1006/exnr.1997.6483, PubMed 9217087

Krobert KA, Sutton RL, Feeney DM (1994)
Spontaneous and amphetamine-evoked release of cerebellar noradrenaline after sensorimotor cortex contusion: an in vivo microdialysis study in the awake rat
J Neurochem, 62 (6), 2233-40
DOI 10.1046/j.1471-4159.1994.62062233.x, PubMed 8189231

Boyeson MG, Scherer PJ, Grade CM, Krobert KA (1993)
Unilateral locus coeruleus lesions facilitate motor recovery from cortical injury through supersensitivity mechanisms
Pharmacol Biochem Behav, 44 (2), 297-305
DOI 10.1016/0091-3057(93)90465-6, PubMed 8446663

Boyeson MG, Krobert KA, Scherer PJ, Grade CM (1993)
Reinstatement of motor deficits in recovered brain-injured animals: the role of cerebellar norepinephrine
Restor Neurol Neurosci, 5 (4), 283-90
DOI 10.3233/RNN-1993-5404, PubMed 21551714

Boyeson MG, Krobert KA, Grade CM, Scherer PJ (1992)
Unilateral, but not bilateral, locus coeruleus lesions facilitate recovery from sensorimotor cortex injury
Pharmacol Biochem Behav, 43 (3), 771-7
DOI 10.1016/0091-3057(92)90407-7, PubMed 1448471

Boyeson MG, Krobert KA (1992)
Cerebellar norepinephrine infusions facilitate recovery after sensorimotor cortex injury
Brain Res Bull, 29 (3-4), 435-9
DOI 10.1016/0361-9230(92)90080-h, PubMed 1393615

Carr JA, Saland LC, Samora A, Benavidez S, Krobert K (1991)
In vivo effects of serotonergic agents on alpha-melanocyte-stimulating hormone secretion
Neuroendocrinology, 54 (6), 616-22
DOI 10.1159/000125968, PubMed 1664500

Book chapters

Ramberg H, Eide T, Krobert KA, Tindall DJ, Levy FO, Taskén KA (2004)
Beta2-adrenergic receptor regulation in prostate cancer upon androgen deprivation
In European urology supplements, Elsevier Science, Oxford, 3(2004)2, Abstrakt 581
BIBSYS 052053962