Publications by Katja Scheffler
34 publications found
Original articles
Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells
Free Radic Biol Med, 213, 470-487
DOI 10.1016/j.freeradbiomed.2024.01.037, PubMed 38301978
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
Free Radic Biol Med, 193 (Pt 2), 685-693
DOI 10.1016/j.freeradbiomed.2022.11.020, PubMed 36395955
Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden
JAMA Netw Open, 5 (11), e2243232
DOI 10.1001/jamanetworkopen.2022.43232, PubMed 36413367
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Commun Biol, 4 (1), 1354
DOI 10.1038/s42003-021-02864-x, PubMed 34857879
Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction
Int J Mol Sci, 22 (23)
DOI 10.3390/ijms222312924, PubMed 34884729
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data
Comput Struct Biotechnol J, 18, 2877-2889
DOI 10.1016/j.csbj.2020.09.038, PubMed 33163148
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease
Free Radic Biol Med, 152, 348-354
DOI 10.1016/j.freeradbiomed.2020.03.030, PubMed 32259578
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy
Neonatology, 115 (4), 355-362
DOI 10.1159/000497200, PubMed 30909283
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
DNA Repair (Amst), 61, 56-62
DOI 10.1016/j.dnarep.2017.11.008, PubMed 29207315
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7 (1), 4384
DOI 10.1038/s41598-017-04472-4, PubMed 28663564
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262
Neil3 induced neurogenesis protects against prion disease during the clinical phase
Sci Rep, 6, 37844
DOI 10.1038/srep37844, PubMed 27886261
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic-ischemic encephalopathy model
Cell Death Dis, 7 (7), e2320
DOI 10.1038/cddis.2016.223, PubMed 27468695
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic Biol Med, 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001, PubMed 27381496
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939
Quantification of DNA Damage by Real-Time qPCR
Methods Mol Biol, 1351, 27-32
DOI 10.1007/978-1-4939-3040-1_3, PubMed 26530672
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Cell Rep, 13 (12), 2671-8
DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335
Analysis of mitochondrial DNA and RNA integrity by a real-time qPCR-based method
Methods Mol Biol, 1264, 97-106
DOI 10.1007/978-1-4939-2257-4_10, PubMed 25631007
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
PLoS One, 9 (5), e96940
DOI 10.1371/journal.pone.0096940, PubMed 24819950
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences
DNA Repair (Amst), 18, 44-51
DOI 10.1016/j.dnarep.2014.03.003, PubMed 24685126
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage
Free Radic Biol Med, 68, 1-7
DOI 10.1016/j.freeradbiomed.2013.11.013, PubMed 24296244
Comparative evaluation of particle properties, formation of reactive oxygen species and genotoxic potential of tungsten carbide based nanoparticles in vitro
J Hazard Mater, 227-228, 418-26
DOI 10.1016/j.jhazmat.2012.04.070, PubMed 22698683
Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis
Acta Neuropathol, 124 (2), 199-208
DOI 10.1007/s00401-012-0980-x, PubMed 22526016
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis
DNA Repair (Amst), 11 (3), 278-85
DOI 10.1016/j.dnarep.2011.12.001, PubMed 22209780
Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease
Curr Alzheimer Res, 8 (7), 781-8
DOI 10.2174/156720511797633179, PubMed 21244350
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
J Clin Invest, 121 (10), 3924-31
DOI 10.1172/JCI57867, PubMed 21881209
Interactive role of trauma cytokines and erythropoietin and their therapeutic potential for acute and chronic wounds
Rejuvenation Res, 14 (1), 57-66
DOI 10.1089/rej.2010.1050, PubMed 21329452
Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI
J Alzheimers Dis, 23 (2), 221-37
DOI 10.3233/JAD-2010-101035, PubMed 20966552
Transcriptional response of zebrafish embryos exposed to neurotoxic compounds reveals a muscle activity dependent hspb11 expression
PLoS One, 6 (12), e29063
DOI 10.1371/journal.pone.0029063, PubMed 22205996
Review articles
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
DNA Repair (Amst), 81, 102665
DOI 10.1016/j.dnarep.2019.102665, PubMed 31327582
Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?
Neurosci Biobehav Rev, 33 (7), 1099-108
DOI 10.1016/j.neubiorev.2009.05.006, PubMed 19481107
Other articles
Safety and efficacy of plasma transfusion from exercise-trained donors in patients with early Alzheimer's disease: protocol for the ExPlas study
BMJ Open, 12 (9), e056964
DOI 10.1136/bmjopen-2021-056964, PubMed 36538409