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Publications by Jon-Vidar Gaustad

53 publications found

Original articles

Gaustad JV, Rofstad EK (2021)
Assessment of Intratumor Heterogeneity in Parametric Dynamic Contrast-Enhanced MR Images: A Comparative Study of Novel and Established Methods
Front Oncol, 11, 722773
DOI 10.3389/fonc.2021.722773, PubMed 34621674

Waldeland JO, Gaustad JV, Rofstad EK, Evje S (2021)
In silico investigations of intratumoral heterogeneous interstitial fluid pressure
J Theor Biol, 526, 110787
DOI 10.1016/j.jtbi.2021.110787, PubMed 34087266

Gaustad JV, Rofstad EK (2021)
Assessment of Hypoxic Tissue Fraction and Prediction of Survival in Cervical Carcinoma by Dynamic Contrast-Enhanced MRI
Front Oncol, 11, 668916
DOI 10.3389/fonc.2021.668916, PubMed 34094964

Gaustad JV, Simonsen TG, Hansem LMK, Rofstad EK (2021)
Intravital microscopy of tumor vessel morphology and function using a standard fluorescence microscope
Eur J Nucl Med Mol Imaging, 48 (10), 3089-3100
DOI 10.1007/s00259-021-05243-0, PubMed 33606081

Simonsen TG, Gaustad JV, Rofstad EK (2020)
Bevacizumab treatment of meningeal melanoma metastases
J Transl Med, 18 (1), 13
DOI 10.1186/s12967-020-02212-3, PubMed 31915016

Gaustad JV, Simonsen TG, Wegner CS, Rofstad EK (2019)
Vascularization, Oxygenation, and the Effect of Sunitinib Treatment in Pancreatic Ductal Adenocarcinoma Xenografts
Front Oncol, 9, 845
DOI 10.3389/fonc.2019.00845, PubMed 31555596

Hansem LMK, Huang R, Wegner CS, Simonsen TG, Gaustad JV, Hauge A, Rofstad EK (2019)
Intratumor Heterogeneity in Interstitial Fluid Pressure in Cervical and Pancreatic Carcinoma Xenografts
Transl Oncol, 12 (8), 1079-1085
DOI 10.1016/j.tranon.2019.05.012, PubMed 31174058

Hauge A, Gaustad JV, Huang R, Simonsen TG, Wegner CS, Andersen LMK, Rofstad EK (2019)
DCE-MRI and Quantitative Histology Reveal Enhanced Vessel Maturation but Impaired Perfusion and Increased Hypoxia in Bevacizumab-Treated Cervical Carcinoma
Int J Radiat Oncol Biol Phys, 104 (3), 666-676
DOI 10.1016/j.ijrobp.2019.03.002, PubMed 30858145

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2018)
Diffusion-Weighted MRI Is Insensitive to Changes in the Tumor Microenvironment Induced by Antiangiogenic Therapy
Transl Oncol, 11 (5), 1128-1136
DOI 10.1016/j.tranon.2018.07.005, PubMed 30036782

Wegner CS, Hauge A, Simonsen TG, Gaustad JV, Andersen LMK, Rofstad EK (2018)
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts
Neoplasia, 20 (7), 734-744
DOI 10.1016/j.neo.2018.05.006, PubMed 29886124

Wegner CS, Hauge A, Andersen LMK, Huang R, Simonsen TG, Gaustad JV, Rofstad EK (2018)
Increasing aggressiveness of patient-derived xenograft models of cervix carcinoma during serial transplantation
Oncotarget, 9 (30), 21036-21051
DOI 10.18632/oncotarget.24783, PubMed 29765518

Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Vascular abnormalities and development of hypoxia in microscopic melanoma xenografts
J Transl Med, 15 (1), 241
DOI 10.1186/s12967-017-1347-9, PubMed 29183378

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer
Oncotarget, 8 (62), 105682-105691
DOI 10.18632/oncotarget.22388, PubMed 29285283

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment
J Transl Med, 15 (1), 225
DOI 10.1186/s12967-017-1331-4, PubMed 29100521

Andersen LMK, Wegner CS, Simonsen TG, Huang R, Gaustad JV, Hauge A, Galappathi K, Rofstad EK (2017)
Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts
Oncotarget, 8 (29), 48060-48074
DOI 10.18632/oncotarget.18231, PubMed 28624797

Wegner CS, Hauge A, Gaustad JV, Andersen LMK, Simonsen TG, Galappathi K, Rofstad EK (2017)
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts
Acta Oncol, 56 (12), 1754-1762
DOI 10.1080/0284186X.2017.1343494, PubMed 28661213

Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts
BMC Cancer, 17 (1), 411
DOI 10.1186/s12885-017-3404-4, PubMed 28606060

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2017)
The Effect of Sunitinib Treatment in Human Melanoma Xenografts: Associations with Angiogenic Profiles
Transl Oncol, 10 (2), 158-167
DOI 10.1016/j.tranon.2016.12.007, PubMed 28167241

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2016)
Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression
Oncotarget, 7 (47), 76806-76815
DOI 10.18632/oncotarget.12695, PubMed 27756886

Rofstad EK, Huang R, Galappathi K, Andersen LM, Wegner CS, Hauge A, Gaustad JV, Simonsen TG (2016)
Functional intratumoral lymphatics in patient-derived xenograft models of squamous cell carcinoma of the uterine cervix: implications for lymph node metastasis
Oncotarget, 7 (35), 56986-56997
DOI 10.18632/oncotarget.10931, PubMed 27486768

Wegner CS, Gaustad JV, Andersen LM, Simonsen TG, Rofstad EK (2016)
Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content
J Transl Med, 14 (1), 161
DOI 10.1186/s12967-016-0920-y, PubMed 27268062

Simonsen TG, Gaustad JV, Rofstad EK (2016)
Intracranial Tumor Cell Migration and the Development of Multiple Brain Metastases in Malignant Melanoma
Transl Oncol, 9 (3), 211-8
DOI 10.1016/j.tranon.2016.04.003, PubMed 27267839

Rofstad EK, Simonsen TG, Huang R, Andersen LM, Galappathi K, Ellingsen C, Wegner CS, Hauge A, Gaustad JV (2016)
Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix
Cancer Lett, 373 (2), 147-55
DOI 10.1016/j.canlet.2016.01.047, PubMed 26828134

Simonsen TG, Gaustad JV, Rofstad EK (2015)
Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases
J Exp Clin Cancer Res, 34, 150
DOI 10.1186/s13046-015-0264-0, PubMed 26667022

Gaustad JV, Simonsen TG, Smistad R, Wegner CS, Andersen LM, Rofstad EK (2015)
Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging
BMC Cancer, 15, 900
DOI 10.1186/s12885-015-1918-1, PubMed 26573613

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2014)
Thrombospondin-1 domain-containing peptide properdistatin improves vascular function in human melanoma xenografts
Microvasc Res, 98, 159-65
DOI 10.1016/j.mvr.2014.02.005, PubMed 24555949

Gaustad JV, Pozdniakova V, Hompland T, Simonsen TG, Rofstad EK (2013)
Magnetic resonance imaging identifies early effects of sunitinib treatment in human melanoma xenografts
J Exp Clin Cancer Res, 32 (1), 93
DOI 10.1186/1756-9966-32-93, PubMed 24245934

Gaustad JV, Simonsen TG, Roa AM, Rofstad EK (2012)
Tumors exposed to acute cyclic hypoxia show increased vessel density and delayed blood supply
Microvasc Res, 85, 10-5
DOI 10.1016/j.mvr.2012.11.002, PubMed 23154277

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
Tumor-line specific causes of intertumor heterogeneity in blood supply in human melanoma xenografts
Microvasc Res, 85, 16-23
DOI 10.1016/j.mvr.2012.11.001, PubMed 23149341

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
Vascular abnormalities associated with acute hypoxia in human melanoma xenografts
Radiother Oncol, 105 (1), 72-8
DOI 10.1016/j.radonc.2012.08.018, PubMed 23022175

Gaustad JV, Simonsen TG, Leinaas MN, Rofstad EK (2012)
Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts
BMC Cancer, 12, 388
DOI 10.1186/1471-2407-12-388, PubMed 22947392

Gaustad JV, Simonsen TG, Leinaas MN, Rofstad EK (2012)
A novel application of dorsal window chambers: repetitive imaging of tumor-associated lymphatics
Microvasc Res, 83 (3), 360-5
DOI 10.1016/j.mvr.2012.02.003, PubMed 22342351

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
High interstitial fluid pressure is associated with tumor-line specific vascular abnormalities in human melanoma xenografts
PLoS One, 7 (6), e40006
DOI 10.1371/journal.pone.0040006, PubMed 22768196

Egeland TA, Gulliksrud K, Gaustad JV, Mathiesen B, Rofstad EK (2011)
Dynamic contrast-enhanced-MRI of tumor hypoxia
Magn Reson Med, 67 (2), 519-30
DOI 10.1002/mrm.23014, PubMed 21661044

Egeland TA, Gaustad JV, Galappathi K, Rofstad EK (2010)
Magnetic resonance imaging of tumor necrosis
Acta Oncol, 50 (3), 427-34
DOI 10.3109/0284186X.2010.526633, PubMed 20950229

Rofstad EK, Gaustad JV, Egeland TA, Mathiesen B, Galappathi K (2010)
Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination
Int J Cancer, 127 (7), 1535-46
DOI 10.1002/ijc.25176, PubMed 20091868

Simonsen TG, Gaustad JV, Rofstad EK (2010)
Development of hypoxia in a preclinical model of tumor micrometastases
Int J Radiat Oncol Biol Phys, 76 (3), 879-88
DOI 10.1016/j.ijrobp.2009.09.045, PubMed 20159362

Rofstad EK, Gaustad JV, Brurberg KG, Mathiesen B, Galappathi K, Simonsen TG (2009)
Radiocurability is associated with interstitial fluid pressure in human tumor xenografts
Neoplasia, 11 (11), 1243-51
DOI 10.1593/neo.91152, PubMed 19881960

Egeland TA, Simonsen TG, Gaustad JV, Gulliksrud K, Ellingsen C, Rofstad EK (2009)
Dynamic contrast-enhanced magnetic resonance imaging of tumors: preclinical validation of parametric images
Radiat Res, 172 (3), 339-47
DOI 10.1667/RR1787.1, PubMed 19708783

Ellingsen C, Egeland TA, Gulliksrud K, Gaustad JV, Mathiesen B, Rofstad EK (2009)
Assessment of hypoxia in human cervical carcinoma xenografts by dynamic contrast-enhanced magnetic resonance imaging
Int J Radiat Oncol Biol Phys, 73 (3), 838-45
DOI 10.1016/j.ijrobp.2008.10.062, PubMed 19215820

Gaustad JV, Simonsen TG, Brurberg KG, Huuse EM, Rofstad EK (2009)
Blood supply in melanoma xenografts is governed by the morphology of the supplying arteries
Neoplasia, 11 (3), 277-85
DOI 10.1593/neo.81400, PubMed 19242609

Ellingsen C, Natvig I, Gaustad JV, Gulliksrud K, Egeland TA, Rofstad EK (2009)
Human cervical carcinoma xenograft models for studies of the physiological microenvironment of tumors
J Cancer Res Clin Oncol, 135 (9), 1177-84
DOI 10.1007/s00432-009-0558-8, PubMed 19214568

Norum OJ, Gaustad JV, Angell-Petersen E, Rofstad EK, Peng Q, Giercksky KE, Berg K (2008)
Photochemical internalization of bleomycin is superior to photodynamic therapy due to the therapeutic effect in the tumor periphery
Photochem Photobiol, 85 (3), 740-9
DOI 10.1111/j.1751-1097.2008.00477.x, PubMed 19076314

Brurberg KG, Gaustad JV, Mollatt CS, Rofstad EK (2008)
Temporal heterogeneity in blood supply in human tumor xenografts
Neoplasia, 10 (7), 727-35
DOI 10.1593/neo.08388, PubMed 18592011

Egeland TA, Gaustad JV, Benjaminsen IC, Hedalen K, Mathiesen B, Rofstad EK (2008)
Assessment of fraction of hypoxic cells in human tumor xenografts with necrotic regions by dynamic contrast-enhanced MRI
Radiat Res, 169 (6), 689-99
DOI 10.1667/RR1311.1, PubMed 18494552

Gaustad JV, Brurberg KG, Simonsen TG, Mollatt CS, Rofstad EK (2008)
Tumor vascularity assessed by magnetic resonance imaging and intravital microscopy imaging
Neoplasia, 10 (4), 354-62
DOI 10.1593/neo.08162, PubMed 18392132

Vestvik IK, Egeland TA, Gaustad JV, Mathiesen B, Rofstad EK (2007)
Assessment of microvascular density, extracellular volume fraction, and radiobiological hypoxia in human melanoma xenografts by dynamic contrast-enhanced MRI
J Magn Reson Imaging, 26 (4), 1033-42
DOI 10.1002/jmri.21110, PubMed 17896373

Øye KS, Gulati G, Graff BA, Gaustad JV, Brurberg KG, Rofstad EK (2007)
A novel method for mapping the heterogeneity in blood supply to normal and malignant tissues in the mouse dorsal window chamber
Microvasc Res, 75 (2), 179-87
DOI 10.1016/j.mvr.2007.06.009, PubMed 17688890

Gaustad JV, Benjaminsen IC, Ruud EB, Rofstad EK (2007)
Dynamic contrast-enhanced magnetic resonance imaging of human melanoma xenografts with necrotic regions
J Magn Reson Imaging, 26 (1), 133-43
DOI 10.1002/jmri.20939, PubMed 17659570

Egeland TA, Gaustad JV, Vestvik IK, Benjaminsen IC, Mathiesen B, Rofstad EK (2006)
Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI
Magn Reson Med, 55 (4), 874-82
DOI 10.1002/mrm.20852, PubMed 16506163

Gaustad JV, Benjaminsen IC, Graff BA, Brurberg KG, Ruud EB, Rofstad EK (2005)
Intratumor heterogeneity in blood perfusion in orthotopic human melanoma xenografts assessed by dynamic contrast-enhanced magnetic resonance imaging
J Magn Reson Imaging, 21 (6), 792-800
DOI 10.1002/jmri.20321, PubMed 15906326

Review articles

Gaustad JV, Hauge A, Wegner CS, Simonsen TG, Lund KV, Hansem LMK, Rofstad EK (2020)
DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness
Cancers (Basel), 12 (7)
DOI 10.3390/cancers12071979, PubMed 32698525

Other articles

Gulliksrud K, Egeland TAM, Gaustad JV, Rofstad EK (2010)
Interstitial fluid pressure of tumors as a function of parameters derived by dynamic contrast-enhanced magnetic resonance imaging: Response to letter by Farace and Boschi
Radiother. Oncol., 94 (3), 385-386
DOI 10.1016/j.radonc.2009.12.025