Publications by Gareth J. Sullivan
72 publications found
Original articles
Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform
J Pediatr Gastroenterol Nutr (in press)
DOI 10.1002/jpn3.12195, PubMed 38529852
Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment
Biomater Biosyst, 14, 100093
DOI 10.1016/j.bbiosy.2024.100093, PubMed 38585282
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids
Adv Sci (Weinh), e2307136 (in press)
DOI 10.1002/advs.202307136, PubMed 38445970
The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease
Int J Biol Sci, 20 (4), 1194-1217
DOI 10.7150/ijbs.91624, PubMed 38385069
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment
Genome Biol, 24 (1), 216
DOI 10.1186/s13059-023-03037-1, PubMed 37773136
3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation
Acta Biomater, 171, 336-349
DOI 10.1016/j.actbio.2023.09.022, PubMed 37734628
Deoxyribonucleoside treatment rescues EtBr-induced mtDNA depletion in iPSC-derived neural stem cells with POLG mutations
FASEB J, 37 (9), e23139
DOI 10.1096/fj.202300650RR, PubMed 37584631
Scalable production of tissue-like vascularized liver organoids from human PSCs
Exp Mol Med, 55 (9), 2005-2024
DOI 10.1038/s12276-023-01074-1, PubMed 37653039
Sensitivity of endogenous autofluorescence in HeLa cells to the application of external magnetic fields
Sci Rep, 13 (1), 10818
DOI 10.1038/s41598-023-38015-x, PubMed 37402779
Aagenaes syndrome/lymphedema cholestasis syndrome 1 is caused by a founder variant in the 5'-untranslated region of UNC45A
J Hepatol, 79 (4), 945-954
DOI 10.1016/j.jhep.2023.05.037, PubMed 37328071
POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia
Exp Neurol, 365, 114429
DOI 10.1016/j.expneurol.2023.114429, PubMed 37105450
"Organ-in-a-Column" Coupled On-line with Liquid Chromatography-Mass Spectrometry
Anal Chem, 94 (50), 17677-17684
DOI 10.1021/acs.analchem.2c04530, PubMed 36484723
Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations
Cell Cycle, 21 (20), 2206-2221
DOI 10.1080/15384101.2022.2092185, PubMed 35815665
POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition
Cell Cycle, 21 (11), 1178-1193
DOI 10.1080/15384101.2022.2044136, PubMed 35298342
Autophagy modulates cell fate decisions during lineage commitment
Autophagy, 18 (8), 1915-1931
DOI 10.1080/15548627.2021.2008691, PubMed 34923909
3D Printed Tooling for Injection Molded Microfluidics
Macromol. Mater. Eng., 306 (11), 2100464
DOI 10.1002/mame.202100464
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
Front Cell Dev Biol, 9, 744777
DOI 10.3389/fcell.2021.744777, PubMed 34722525
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations
Front Cell Dev Biol, 9, 737304
DOI 10.3389/fcell.2021.737304, PubMed 34631714
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
J Hepatol, 75 (4), 935-959
DOI 10.1016/j.jhep.2021.06.021, PubMed 34171436
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities
Cell Rep Med, 2 (4), 100240
DOI 10.1016/j.xcrm.2021.100240, PubMed 33948573
Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies
Anal Chem, 93 (7), 3576-3585
DOI 10.1021/acs.analchem.0c05082, PubMed 33534551
How well do brain organoids capture your brain?
iScience, 24 (2), 102063
DOI 10.1016/j.isci.2021.102063, PubMed 33554067
N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation
Exp Neurol, 337, 113536
DOI 10.1016/j.expneurol.2020.113536, PubMed 33264635
A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates
Sci Rep, 10 (1), 18498
DOI 10.1038/s41598-020-73656-2, PubMed 33116175
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations
EMBO Mol Med, 12 (10), e12146
DOI 10.15252/emmm.202012146, PubMed 32840960
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons
Mol Cell, 79 (1), 84-98.e9
DOI 10.1016/j.molcel.2020.05.016, PubMed 32526163
Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain
Cell Rep, 30 (6), 1682-1689.e3
DOI 10.1016/j.celrep.2020.01.038, PubMed 32049002
Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties
Sci Rep, 9 (1), 12934
DOI 10.1038/s41598-019-49016-0, PubMed 31506459
Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells
Front Physiol, 9, 1635
DOI 10.3389/fphys.2018.01635, PubMed 30524301
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
Nat Commun, 9 (1), 2583
DOI 10.1038/s41467-018-04818-0, PubMed 29968706
Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth
Sci Rep, 8 (1), 6168
DOI 10.1038/s41598-018-24421-z, PubMed 29670257
Rapid Screening of the Endodermal Differentiation Potential of Human Pluripotent Stem Cells
Curr Protoc Stem Cell Biol, 43, 1G.7.1-1G.7.23
DOI 10.1002/cpsc.36, PubMed 29140570
Future Challenges in the Generation of Hepatocyte-Like Cells From Human Pluripotent Stem Cells
Curr. Pathobiol. Rep., 5 (3), 301-314
DOI 10.1007/s40139-017-0150-x
Development of an inducible platform for intercellular protein delivery
Int J Pharm, 522 (1-2), 1-10
DOI 10.1016/j.ijpharm.2017.02.067, PubMed 28254654
Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver
Sci Rep, 7, 37541
DOI 10.1038/srep37541, PubMed 28134251
Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines
Sci Rep, 6, 37178
DOI 10.1038/srep37178, PubMed 27872482
Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells
Curr Protoc Stem Cell Biol, 38, 1G.6.1-1G.6.18
DOI 10.1002/cpsc.13, PubMed 27532814
Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly
Stem Cells Transl Med, 5 (9), 1171-81
DOI 10.5966/sctm.2015-0384, PubMed 27388238
Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells
Stem Cell Reports, 4 (5), 939-52
DOI 10.1016/j.stemcr.2015.04.001, PubMed 25937370
Investigation of Rett syndrome using pluripotent stem cells
J Cell Biochem, 114 (11), 2446-53
DOI 10.1002/jcb.24597, PubMed 23744605
Modelling human disease with pluripotent stem cells
Curr Gene Ther, 13 (2), 99-110
DOI 10.2174/1566523211313020004, PubMed 23444871
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA
Cell Rep, 2 (4), 799-806
DOI 10.1016/j.celrep.2012.08.025, PubMed 23022481
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Proc Natl Acad Sci U S A, 109 (15), 5803-8
DOI 10.1073/pnas.1202922109, PubMed 22451909
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development
Cell Res, 21 (9), 1332-42
DOI 10.1038/cr.2011.113, PubMed 21747414
Dynamic micro-Hall detection of superparamagnetic beads in a microfluidic channel
J Magn Magn Mater, 322 (24), L69-L72
DOI 10.1016/j.jmmm.2010.08.006, PubMed 21655331
Generation of functional human hepatic endoderm from human induced pluripotent stem cells
Hepatology, 51 (1), 329-35
DOI 10.1002/hep.23335, PubMed 19877180
Near-surface nanoscale InAs Hall cross sensitivity to localized magnetic and electric fields
J Phys Condens Matter, 21 (25), 255802
DOI 10.1088/0953-8984/21/25/255802, PubMed 21828442
UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat
Mol Cell Biol, 22 (2), 657-68
DOI 10.1128/MCB.22.2.657-668.2002, PubMed 11756560
Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli
EMBO J, 20 (11), 2867-74
DOI 10.1093/emboj/20.11.2867, PubMed 11387219
Medical malpractice tort reform in California
Cost Qual, 5 (3), 27-8, 33
PubMed 10622985
Dimerization and HMG box domains 1-3 present in Xenopus UBF are sufficient for its role in transcriptional enhancement
Nucleic Acids Res, 26 (15), 3555-61
DOI 10.1093/nar/26.15.3555, PubMed 9671818
The Xenopus RNA polymerase I transcription factor, UBF, has a role in transcriptional enhancement distinct from that at the promoter
EMBO J, 16 (2), 396-405
DOI 10.1093/emboj/16.2.396, PubMed 9029158
Efficient quadtree coding of images and video
IEEE Trans Image Process, 3 (3), 327-31
DOI 10.1109/83.287030, PubMed 18291934
Overlapped block motion compensation: an estimation-theoretic approach
IEEE Trans Image Process, 3 (5), 693-9
DOI 10.1109/83.334974, PubMed 18291963
Recursive optimal pruning with applications to tree structured vector quantizers
IEEE Trans Image Process, 1 (2), 162-9
DOI 10.1109/83.136593, PubMed 18296151
Nucleotide sequence of a repetitive element isolated from Leptospira interrogans serovar hardjo type hardjo-bovis
J Gen Microbiol, 137 (5), 1101-9
DOI 10.1099/00221287-137-5-1101, PubMed 1650813
Development of a PCR test specific for Leptospira hardjo genotype bovis
Vet Rec, 128 (12), 282-3
DOI 10.1136/vr.128.12.282, PubMed 2038811
Review articles
"iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives"
Front Physiol, 14, 1094249
DOI 10.3389/fphys.2023.1094249, PubMed 36711019
Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview
Front Pharmacol, 13, 835825
DOI 10.3389/fphar.2022.835825, PubMed 35721220
Liver Organoids: Recent Developments, Limitations and Potential
Front Med (Lausanne), 8, 574047
DOI 10.3389/fmed.2021.574047, PubMed 34026769
3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry
Electrophoresis, 41 (1-2), 56-64
DOI 10.1002/elps.201900170, PubMed 31544246
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
NPJ Regen Med, 2, 28
DOI 10.1038/s41536-017-0029-9, PubMed 29302362
Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification
J Am Heart Assoc, 6 (9)
DOI 10.1161/JAHA.117.006339, PubMed 28912209
Cellular reprogramming: a novel tool for investigating autism spectrum disorders
Trends Mol Med, 18 (8), 463-71
DOI 10.1016/j.molmed.2012.06.002, PubMed 22771169
Humanized murine model for HBV and HCV using human induced pluripotent stem cells
Arch Pharm Res, 35 (2), 261-9
DOI 10.1007/s12272-012-0206-8, PubMed 22370780
Biomedical and social contributions to sustainability
Philos Trans A Math Phys Eng Sci, 369 (1942), 1730-47
DOI 10.1098/rsta.2010.0370, PubMed 21464068
Induced pluripotent stem cells: epigenetic memories and practical implications
Mol Hum Reprod, 16 (12), 880-5
DOI 10.1093/molehr/gaq091, PubMed 21059705
Hepatic endoderm differentiation from human embryonic stem cells
Curr Stem Cell Res Ther, 5 (3), 233-44
DOI 10.2174/157488810791824403, PubMed 20214561
A decade of progress since the birth of Dolly
Reprod Fertil Dev, 21 (1), 95-100
DOI 10.1071/rd08216, PubMed 19152750
Other articles
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells"
Sci Transl Med, 5 (188), 188le2
DOI 10.1126/scitranslmed.3005065, PubMed 23740897
The evolving biology of cell reprogramming
Philos Trans R Soc Lond B Biol Sci, 366 (1575), 2183-97
DOI 10.1098/rstb.2011.0051, PubMed 21727124
What are the limits to cell plasticity?
Cell Res, 20 (5), 502-3
DOI 10.1038/cr.2010.59, PubMed 20436508