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Publications by Ornella Manfra

15 publications found

Original articles

Lunde PK, Manfra O, Støle TP, Lunde M, Martinsen M, Carlson CR, Louch WE (2023)
Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Cells, 12 (19)
DOI 10.3390/cells12192358, PubMed 37830576

Manfra O, Louey S, Jonker SS, Perdreau-Dahl H, Frisk M, Giraud GD, Thornburg KL, Louch WE (2023)
Augmenting workload drives T-tubule assembly in developing cardiomyocytes
J Physiol (in press)
DOI 10.1113/JP284538, PubMed 37128962

Manfra O, Calamera G, Froese A, Arunthavarajah D, Surdo NC, Meier S, Melleby AO, Aasrum M, Aronsen JM, Nikolaev VO, Zaccolo M, Moltzau LR, Levy FO, Andressen KW (2022)
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors
Cardiovasc Res, 118 (6), 1506-1519
DOI 10.1093/cvr/cvab167, PubMed 33970224

Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397

Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE (2020)
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
DOI 10.1161/CIRCRESAHA.119.315641, PubMed 32070187

Røe ÅT, Ruud M, Espe EK, Manfra O, Longobardi S, Aronsen JM, Nordén ES, Husebye T, Kolstad TRS, Cataliotti A, Christensen G, Sejersted OM, Niederer SA, Andersen GØ, Sjaastad I, Louch WE (2019)
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410

Ulsund AH, Dahl M, Frimurer TM, Manfra O, Schwartz TW, Levy FO, Andressen KW (2018)
Preassociation between the 5-HT₇ serotonin receptor and G protein G_s: molecular determinants and association with low potency activation of adenylyl cyclase
FASEB J, 33 (3), 3870-3886
DOI 10.1096/fj.201800805RR, PubMed 30508496

Todd Milne G, on behalf of the Ironwood team, Sandner P, Lincoln KA, Harrison PC, Chen H, Wang H, Clifford H, Qian HS, Wong D, Sarko C, Fryer R, Richman J, Reinhart GA, Boustany CM, Pullen SS, Andresen H, Moltzau LR, Cataliotti A, Levy FO, Lukowski R, Frankenreiter S, Friebe A, Calamaras T, Baumgartner R et al. (2017)
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017
BMC Pharmacol Toxicol, 18 (Suppl 1), 64
DOI 10.1186/s40360-017-0170-5, PubMed 29035170

Lubelwana Hafver T, Wanichawan P, Manfra O, de Souza GA, Lunde M, Martinsen M, Louch WE, Sejersted OM, Carlson CR (2017)
Mapping the in vitro interactome of cardiac sodium (Na⁺ )-calcium (Ca²⁺ ) exchanger 1 (NCX1)
Proteomics, 17 (17-18)
DOI 10.1002/pmic.201600417, PubMed 28755400

Andressen KW, Manfra O, Brevik CH, Ulsund AH, Vanhoenacker P, Levy FO, Krobert KA (2015)
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors
Br J Pharmacol, 172 (15), 3846-60
DOI 10.1111/bph.13169, PubMed 25884989

Impellizzeri AA, Pappalardo M, Basile L, Manfra O, Andressen KW, Krobert KA, Messina A, Levy FO, Guccione S (2015)
Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis
Front Behav Neurosci, 9, 92
DOI 10.3389/fnbeh.2015.00092, PubMed 26005408

Manfra O, Van Craenenbroeck K, Skieterska K, Frimurer T, Schwartz TW, Levy FO, Andressen KW (2015)
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1
ACS Chem Neurosci, 6 (7), 1206-18
DOI 10.1021/cn500339p, PubMed 25706089

Ørstavik Ø, Manfra O, Andressen KW, Andersen GØ, Skomedal T, Osnes JB, Levy FO, Krobert KA (2015)
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium
PLoS One, 10 (3), e0115547
DOI 10.1371/journal.pone.0115547, PubMed 25738589

Brudeli B, Navaratnarajah M, Andressen KW, Manfra O, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2014)
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists
Bioorg Med Chem Lett, 24 (18), 4598-4602
DOI 10.1016/j.bmcl.2014.06.083, PubMed 25149506

Review articles

Manfra O, Frisk M, Louch WE (2017)
Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy
Curr Heart Fail Rep, 14 (3), 167-178
DOI 10.1007/s11897-017-0329-9, PubMed 28447290