Publication list - Publika - Scientific publications from Oslo University Hospital

Publications by Germana Rappa

62 publications found

Original articles

Santos MF, Rappa G, Karbanová J, Diana P, Cirrincione G, Carbone D, Manna D, Aalam F, Wang D, Vanier C, Corbeil D, Lorico A (2023)
HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells
Nat Commun, 14 (1), 4588
DOI 10.1038/s41467-023-40227-8, PubMed 37563144

Santos MF, Rappa G, Fontana S, Karbanová J, Aalam F, Tai D, Li Z, Pucci M, Alessandro R, Morimoto C, Corbeil D, Lorico A (2022)
Anti-Human CD9 Fab Fragment Antibody Blocks the Extracellular Vesicle-Mediated Increase in Malignancy of Colon Cancer Cells
Cells, 11 (16)
DOI 10.3390/cells11162474, PubMed 36010551

Santos MF, Rappa G, Karbanová J, Fontana S, Bella MAD, Pope MR, Parrino B, Cascioferro SM, Vistoli G, Diana P, Cirrincione G, Arena GO, Woo G, Huang K, Huynh T, Moschetti M, Alessandro R, Corbeil D, Lorico A (2021)
Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum
J Extracell Vesicles, 10 (10), e12132
DOI 10.1002/jev2.12132, PubMed 34429859

Santos MF, Rappa G, Karbanová J, Vanier C, Morimoto C, Corbeil D, Lorico A (2019)
Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins
J Cell Mol Med, 23 (6), 4408-4421
DOI 10.1111/jcmm.14334, PubMed 30982221

Osti D, Del Bene M, Rappa G, Santos M, Matafora V, Richichi C, Faletti S, Beznoussenko GV, Mironov A, Bachi A, Fornasari L, Bongetta D, Gaetani P, DiMeco F, Lorico A, Pelicci G (2018)
Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients
Clin Cancer Res, 25 (1), 266-276
DOI 10.1158/1078-0432.CCR-18-1941, PubMed 30287549

Santos MF, Rappa G, Karbanová J, Kurth T, Corbeil D, Lorico A (2018)
VAMP-associated protein-A and oxysterol-binding protein-related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum
J Biol Chem, 293 (36), 13834-13848
DOI 10.1074/jbc.RA118.003725, PubMed 30018135

Chao OS, Chang TC, Di Bella MA, Alessandro R, Anzanello F, Rappa G, Goodman OB, Lorico A (2017)
The HDAC6 Inhibitor Tubacin Induces Release of CD133⁺ Extracellular Vesicles From Cancer Cells
J Cell Biochem, 118 (12), 4414-4424
DOI 10.1002/jcb.26095, PubMed 28452069

Rappa G, Santos MF, Green TM, Karbanová J, Hassler J, Bai Y, Barsky SH, Corbeil D, Lorico A (2017)
Nuclear transport of cancer extracellular vesicle-derived biomaterials through nuclear envelope invagination-associated late endosomes
Oncotarget, 8 (9), 14443-14461
DOI 10.18632/oncotarget.14804, PubMed 28129640

Setti M, Osti D, Richichi C, Ortensi B, Del Bene M, Fornasari L, Beznoussenko G, Mironov A, Rappa G, Cuomo A, Faretta M, Bonaldi T, Lorico A, Pelicci G (2015)
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth
Oncotarget, 6 (31), 31413-27
DOI 10.18632/oncotarget.5105, PubMed 26429879

Rappa G, Anzanello F, Lorico A (2015)
Ethanol induces upregulation of the nerve growth factor receptor CD271 in human melanoma cells via nuclear factor-κB activation
Oncol Lett, 10 (2), 815-821
DOI 10.3892/ol.2015.3343, PubMed 26622576

Rappa G, Green TM, Karbanová J, Corbeil D, Lorico A (2015)
Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells
Oncotarget, 6 (10), 7970-91
DOI 10.18632/oncotarget.3419, PubMed 25762645

Rappa G, Green TM, Lorico A (2014)
The nuclear pool of tetraspanin CD9 contributes to mitotic processes in human breast carcinoma
Mol Cancer Res, 12 (12), 1840-50
DOI 10.1158/1541-7786.MCR-14-0242, PubMed 25103498

Rappa G, Mercapide J, Anzanello F, Pope RM, Lorico A (2013)
Biochemical and biological characterization of exosomes containing prominin-1/CD133
Mol Cancer, 12, 62
DOI 10.1186/1476-4598-12-62, PubMed 23767874

Rappa G, Mercapide J, Anzanello F, Le TT, Johlfs MG, Fiscus RR, Wilsch-Bräuninger M, Corbeil D, Lorico A (2013)
Wnt interaction and extracellular release of prominin-1/CD133 in human malignant melanoma cells
Exp Cell Res, 319 (6), 810-9
DOI 10.1016/j.yexcr.2013.01.003, PubMed 23318676

Lorico A, Mercapide J, Rappa G (2013)
Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives
Adv Exp Med Biol, 777, 197-211
DOI 10.1007/978-1-4614-5894-4_13, PubMed 23161084

Rappa G, Mercapide J, Lorico A (2012)
Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity
Am J Pathol, 180 (6), 2504-15
DOI 10.1016/j.ajpath.2012.02.020, PubMed 22542847

Mercapide J, Anzanello F, Rappa G, Lorico A (2012)
Relationship between tumor cell invasiveness and polyploidization
PLoS One, 7 (12), e53364
DOI 10.1371/journal.pone.0053364, PubMed 23300919

Mercapide J, Rappa G, Lorico A (2011)
The intrinsic fusogenicity of glioma cells as a factor of transformation and progression in the tumor microenvironment
Int J Cancer, 131 (2), 334-43
DOI 10.1002/ijc.26361, PubMed 21858806

Lorico A, Rappa G (2011)
Phenotypic heterogeneity of breast cancer stem cells
J Oncol, 2011, 135039
DOI 10.1155/2011/135039, PubMed 21317983

Rappa G, Anzanello F, Lorico A (2010)
Imatinib mesylate enhances the malignant behavior of human breast carcinoma cells
Cancer Chemother Pharmacol, 67 (4), 919-26
DOI 10.1007/s00280-010-1394-x, PubMed 20596710

Mercapide J, Rappa G, Anzanello F, King J, Fodstad O, Lorico A (2010)
Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma
Int J Cancer, 126 (5), 1206-15
DOI 10.1002/ijc.24809, PubMed 19653275

Rappa G, Lorico A (2010)
Phenotypic characterization of mammosphere-forming cells from the human MA-11 breast carcinoma cell line
Exp Cell Res, 316 (9), 1576-86
DOI 10.1016/j.yexcr.2010.01.012, PubMed 20074564

Rappa G, Fodstad O, Lorico A (2008)
The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma
Stem Cells, 26 (12), 3008-17
DOI 10.1634/stemcells.2008-0601, PubMed 18802032

Lorico A, Mercapide J, Solodushko V, Alexeyev M, Fodstad O, Rappa G (2008)
Primary neural stem/progenitor cells expressing endostatin or cytochrome P450 for gene therapy of glioblastoma
Cancer Gene Ther, 15 (9), 605-15
DOI 10.1038/cgt.2008.23, PubMed 18421309

Rappa G, Mercapide J, Anzanello F, Prasmickaite L, Xi Y, Ju J, Fodstad O, Lorico A (2008)
Growth of cancer cell lines under stem cell-like conditions has the potential to unveil therapeutic targets
Exp Cell Res, 314 (10), 2110-22
DOI 10.1016/j.yexcr.2008.03.008, PubMed 18423605

Rappa G, Anzanello F, Alexeyev M, Fodstad O, Lorico A (2007)
Gamma-glutamylcysteine synthetase-based selection strategy for gene therapy of chronic granulomatous disease and graft-vs.-host disease
Eur J Haematol, 78 (5), 440-8
DOI 10.1111/j.1600-0609.2007.00833.x, PubMed 17331133

Lorico A, Bratbak D, Meyer J, Kunke D, Krauss S, Plott WE, Solodushko V, Baum C, Fodstad O, Rappa G (2005)
Gamma-glutamylcysteine synthetase and L-buthionine-(S,R)-sulfoximine: a new selection strategy for gene-transduced neural and hematopoietic stem/progenitor cells
Hum Gene Ther, 16 (6), 711-24
DOI 10.1089/hum.2005.16.711, PubMed 15960602

Rappa G, Kunke D, Holter J, Diep DB, Meyer J, Baum C, Fodstad O, Krauss S, Lorico A (2004)
Efficient expansion and gene transduction of mouse neural stem/progenitor cells on recombinant fibronectin
Neuroscience, 124 (4), 823-30
DOI 10.1016/j.neuroscience.2003.11.030, PubMed 15026123

Cisternino S, Rousselle C, Lorico A, Rappa G, Scherrmann JM (2003)
Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells
Pharm Res, 20 (6), 904-9
DOI 10.1023/a:1023895404929, PubMed 12817896

Rappa G, Gamcsik MP, Mitina RL, Baum C, Fodstad O, Lorico A (2003)
Retroviral transfer of MRP1 and gamma-glutamyl cysteine synthetase modulates cell sensitivity to L-buthionine-S,R-sulphoximine (BSO): new rationale for the use of BSO in cancer therapy
Eur J Cancer, 39 (1), 120-8
DOI 10.1016/s0959-8049(02)00447-1, PubMed 12504668

Lorico A, Bertola A, Baum C, Fodstad O, Rappa G (2002)
Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice
Biochem Biophys Res Commun, 291 (3), 617-22
DOI 10.1006/bbrc.2002.6489, PubMed 11855834

Lorico A, Nesland J, Emilsen E, Fodstad O, Rappa G (2002)
Role of the multidrug resistance protein 1 gene in the carcinogenicity of aflatoxin B1: investigations using mrp1-null mice
Toxicology, 171 (2-3), 201-5
DOI 10.1016/s0300-483x(01)00584-4, PubMed 11836025

Rappa G, Lorico A, Hildinger M, Fodstad Ø, Baum C (2001)
Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents
Hum Gene Ther, 12 (14), 1785-96
DOI 10.1089/104303401750476276, PubMed 11560771

Abraham EH, Sterling KM, Kim RJ, Salikhova AY, Huffman HB, Crockett MA, Johnston N, Parker HW, Boyle WE, Hartov A, Demidenko E, Efird J, Kahn J, Grubman SA, Jefferson DM, Robson SC, Thakar JH, Lorico A, Rappa G, Sartorelli AC, Okunieff P (2001)
Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis
Blood Cells Mol Dis, 27 (1), 165-80
DOI 10.1006/bcmd.2000.0357, PubMed 11358378

Rappa G, Murren JR, Johnson LM, Lorico A, Sartorelli AC (2000)
Novobiocin-induced VP-16 accumulation and MRP expression in human leukemia and ovarian carcinoma cells
Anticancer Drug Des, 15 (2), 127-34
PubMed 10901300

Murren JR, DiStasio SA, Lorico A, McKeon A, Zuhowski EG, Egorin MJ, Sartorelli AC, Rappa G (2000)
Phase I and pharmacokinetic study of novobiocin in combination with VP-16 in patients with refractory malignancies
Cancer J, 6 (4), 256-65
PubMed 11038146

Rappa G, Shyam K, Lorico A, Fodstad O, Sartorelli AC (2000)
Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16)
Oncol Res, 12 (3), 113-9
DOI 10.3727/096504001108747585, PubMed 11216669

Rappa G, Finch RA, Sartorelli AC, Lorico A (1999)
New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models
Biochem Pharmacol, 58 (4), 557-62
DOI 10.1016/s0006-2952(99)00074-x, PubMed 10413292

Rappa G, Lorico A, Flavell RA, Sartorelli AC (1997)
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins
Cancer Res, 57 (23), 5232-7
PubMed 9393740

Lorico A, Rappa G, Finch RA, Yang D, Flavell RA, Sartorelli AC (1997)
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione
Cancer Res, 57 (23), 5238-42
PubMed 9393741

Rappa G, Lorico A, Liu MC, Kruh GD, Cory AH, Cory JG, Sartorelli AC (1997)
Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase
Biochem Pharmacol, 54 (6), 649-55
DOI 10.1016/s0006-2952(97)00210-4, PubMed 9310341

Cory JG, Cory AH, Lorico A, Rappa G, Sartorelli AC (1997)
Altered efflux properties of mouse leukemia L1210 cells resistant to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone
Anticancer Res, 17 (5A), 3185-93
PubMed 9413147

Lorico A, Rappa G, Flavell RA, Sartorelli AC (1996)
Double knockout of the MRP gene leads to increased drug sensitivity in vitro
Cancer Res, 56 (23), 5351-5
PubMed 8968083

Lorico A, Rappa G, Srimatkandada S, Catapano CV, Fernandes DJ, Germino JF, Sartorelli AC (1995)
Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene
Cancer Res, 55 (19), 4352-60
PubMed 7671247

Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, Sartorelli AC (1995)
Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo
Adv Enzyme Regul, 35, 55-68
DOI 10.1016/0065-2571(94)00005-n, PubMed 7572354

Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, Sartorelli AC (1994)
Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones
Biochem Pharmacol, 48 (2), 335-44
DOI 10.1016/0006-2952(94)90105-8, PubMed 8053929

Rappa G, Lorico A, Sartorelli AC (1993)
Reversal of etoposide resistance in non-P-glycoprotein expressing multidrug resistant tumor cell lines by novobiocin
Cancer Res, 53 (22), 5487-93
PubMed 8106148

Lorico A, Rappa G, Sartorelli AC (1992)
Novobiocin-induced accumulation of etoposide (VP-16) in WEHI-3B D+ leukemia cells
Int J Cancer, 52 (6), 903-9
DOI 10.1002/ijc.2910520613, PubMed 1334054

Rappa G, Lorico A, Sartorelli AC (1992)
Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26)
Int J Cancer, 51 (5), 780-7
DOI 10.1002/ijc.2910510519, PubMed 1377186

Rappa G, Lorico A, Sartorelli AC (1992)
Development and characterization of a WEHI-3B D+ monomyelocytic leukemia cell line resistant to novobiocin and cross-resistant to other topoisomerase II-targeted drugs
Cancer Res, 52 (10), 2782-90
PubMed 1316227

Rappa G, Lorico A, Sartorelli AC (1990)
Induction of the differentiation of WEHI-3B D+ monomyelocytic leukemia cells by inhibitors of topoisomerase II
Cancer Res, 50 (20), 6723-30
PubMed 2170008

Lorico A, Boiocchi M, Rappa G, Sen S, Erba E, D'Incalci M (1990)
Increase in topoisomerase-II-mediated DNA breaks and cytotoxicity of VP16 in human U937 lymphoma cells pretreated with low doses of methotrexate
Int J Cancer, 45 (1), 156-62
DOI 10.1002/ijc.2910450128, PubMed 2153635

Lorico A, Toffoli G, Boiocchi M, Erba E, Broggini M, Rappa G, D'Incalci M (1988)
Early DNA damage induced in cells exposed to N10-propargyl 5,8-dideazafolic acid (CB 3717) or methotrexate
Biochem Pharmacol, 37 (9), 1875-6
DOI 10.1016/0006-2952(88)90490-x, PubMed 3377859

Lorico A, Rappa G, Boiocchi M, Anzanello F, D'Incalci M (1988)
Increase in etoposide-induced topoisomerase II-mediated DNA breaks after cell synchronization induced by low doses of methotrexate
Biochem Pharmacol, 37 (9), 1883-4
DOI 10.1016/0006-2952(88)90494-7, PubMed 2837248

Lorico A, Toffoli G, Boiocchi M, Erba E, Broggini M, Rappa G, D'Incalci M (1988)
Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid
Cancer Res, 48 (8), 2036-41
PubMed 3349474

Review articles

Corbeil D, Santos MF, Karbanová J, Kurth T, Rappa G, Lorico A (2020)
Uptake and Fate of Extracellular Membrane Vesicles: Nucleoplasmic Reticulum-Associated Late Endosomes as a New Gate to Intercellular Communication
Cells, 9 (9)
DOI 10.3390/cells9091931, PubMed 32825578

Rappa G, Puglisi C, Santos MF, Forte S, Memeo L, Lorico A (2019)
Extracellular Vesicles from Thyroid Carcinoma: The New Frontier of Liquid Biopsy
Int J Mol Sci, 20 (5)
DOI 10.3390/ijms20051114, PubMed 30841521

Green TM, Santos MF, Barsky SH, Rappa G, Lorico A (2016)
Analogies Between Cancer-Derived Extracellular Vesicles and Enveloped Viruses with an Emphasis on Human Breast Cancer
Curr Pathobiol Rep, 4 (4), 169-179
DOI 10.1007/s40139-016-0116-4, PubMed 32226654

Green TM, Alpaugh ML, Barsky SH, Rappa G, Lorico A (2015)
Breast Cancer-Derived Extracellular Vesicles: Characterization and Contribution to the Metastatic Phenotype
Biomed Res Int, 2015, 634865
DOI 10.1155/2015/634865, PubMed 26601108

Murren JR, Rappa G, Cheng YC (1996)
Multifunctional modulators of drug resistance
Cancer Treat Res, 87, 381-408
DOI 10.1007/978-1-4613-1267-3_16, PubMed 8886462