Publications by Aurelio Lorico
82 publications found
Original articles
Extracellular lipidosomes containing lipid droplets and mitochondria are released during melanoma cell division
Cell Commun Signal, 22 (1), 57
DOI 10.1186/s12964-024-01471-7, PubMed 38243233
HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells
Nat Commun, 14 (1), 4588
DOI 10.1038/s41467-023-40227-8, PubMed 37563144
Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes
Cancer Cell Int, 23 (1), 77
DOI 10.1186/s12935-023-02916-8, PubMed 37072829
Anti-Human CD9 Fab Fragment Antibody Blocks the Extracellular Vesicle-Mediated Increase in Malignancy of Colon Cancer Cells
Cells, 11 (16)
DOI 10.3390/cells11162474, PubMed 36010551
Ex Vivo Irradiation of Lung Cancer Stem Cells Identifies the Lowest Therapeutic Dose Needed for Tumor Growth Arrest and Mass Reduction In Vivo
Front Oncol, 12, 837400
DOI 10.3389/fonc.2022.837400, PubMed 35646627
Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum
J Extracell Vesicles, 10 (10), e12132
DOI 10.1002/jev2.12132, PubMed 34429859
Oncosuppressor-Mutated Cell-Based Diagnostic Platform for Liquid Biopsy Diagnoses Benign Head and Neck Masses and Predicts Malignancy in Thyroid Nodules: Results from a Consecutive Cohort of Patients
Eur Thyroid J, 10 (4), 285-294
DOI 10.1159/000516421, PubMed 34395300
Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins
J Cell Mol Med, 23 (6), 4408-4421
DOI 10.1111/jcmm.14334, PubMed 30982221
Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients
Clin Cancer Res, 25 (1), 266-276
DOI 10.1158/1078-0432.CCR-18-1941, PubMed 30287549
VAMP-associated protein-A and oxysterol-binding protein-related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum
J Biol Chem, 293 (36), 13834-13848
DOI 10.1074/jbc.RA118.003725, PubMed 30018135
The HDAC6 Inhibitor Tubacin Induces Release of CD133+ Extracellular Vesicles From Cancer Cells
J Cell Biochem, 118 (12), 4414-4424
DOI 10.1002/jcb.26095, PubMed 28452069
Nuclear transport of cancer extracellular vesicle-derived biomaterials through nuclear envelope invagination-associated late endosomes
Oncotarget, 8 (9), 14443-14461
DOI 10.18632/oncotarget.14804, PubMed 28129640
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth
Oncotarget, 6 (31), 31413-27
DOI 10.18632/oncotarget.5105, PubMed 26429879
Ethanol induces upregulation of the nerve growth factor receptor CD271 in human melanoma cells via nuclear factor-κB activation
Oncol Lett, 10 (2), 815-821
DOI 10.3892/ol.2015.3343, PubMed 26622576
Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells
Oncotarget, 6 (10), 7970-91
DOI 10.18632/oncotarget.3419, PubMed 25762645
Adhesion signaling promotes protease‑driven polyploidization of glioblastoma cells
Int J Mol Med, 34 (5), 1365-71
DOI 10.3892/ijmm.2014.1913, PubMed 25174945
The nuclear pool of tetraspanin CD9 contributes to mitotic processes in human breast carcinoma
Mol Cancer Res, 12 (12), 1840-50
DOI 10.1158/1541-7786.MCR-14-0242, PubMed 25103498
Biochemical and biological characterization of exosomes containing prominin-1/CD133
Mol Cancer, 12, 62
DOI 10.1186/1476-4598-12-62, PubMed 23767874
Wnt interaction and extracellular release of prominin-1/CD133 in human malignant melanoma cells
Exp Cell Res, 319 (6), 810-9
DOI 10.1016/j.yexcr.2013.01.003, PubMed 23318676
Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives
Adv Exp Med Biol, 777, 197-211
DOI 10.1007/978-1-4614-5894-4_13, PubMed 23161084
Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity
Am J Pathol, 180 (6), 2504-15
DOI 10.1016/j.ajpath.2012.02.020, PubMed 22542847
Relationship between tumor cell invasiveness and polyploidization
PLoS One, 7 (12), e53364
DOI 10.1371/journal.pone.0053364, PubMed 23300919
The intrinsic fusogenicity of glioma cells as a factor of transformation and progression in the tumor microenvironment
Int J Cancer, 131 (2), 334-43
DOI 10.1002/ijc.26361, PubMed 21858806
Phenotypic heterogeneity of breast cancer stem cells
J Oncol, 2011, 135039
DOI 10.1155/2011/135039, PubMed 21317983
Cancer stem cells
J Oncol, 2011, 269437
DOI 10.1155/2011/269437, PubMed 21603197
Imatinib mesylate enhances the malignant behavior of human breast carcinoma cells
Cancer Chemother Pharmacol, 67 (4), 919-26
DOI 10.1007/s00280-010-1394-x, PubMed 20596710
Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma
Int J Cancer, 126 (5), 1206-15
DOI 10.1002/ijc.24809, PubMed 19653275
Phenotypic characterization of mammosphere-forming cells from the human MA-11 breast carcinoma cell line
Exp Cell Res, 316 (9), 1576-86
DOI 10.1016/j.yexcr.2010.01.012, PubMed 20074564
The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma
Stem Cells, 26 (12), 3008-17
DOI 10.1634/stemcells.2008-0601, PubMed 18802032
Primary neural stem/progenitor cells expressing endostatin or cytochrome P450 for gene therapy of glioblastoma
Cancer Gene Ther, 15 (9), 605-15
DOI 10.1038/cgt.2008.23, PubMed 18421309
Growth of cancer cell lines under stem cell-like conditions has the potential to unveil therapeutic targets
Exp Cell Res, 314 (10), 2110-22
DOI 10.1016/j.yexcr.2008.03.008, PubMed 18423605
Gamma-glutamylcysteine synthetase-based selection strategy for gene therapy of chronic granulomatous disease and graft-vs.-host disease
Eur J Haematol, 78 (5), 440-8
DOI 10.1111/j.1600-0609.2007.00833.x, PubMed 17331133
Gamma-glutamylcysteine synthetase and L-buthionine-(S,R)-sulfoximine: a new selection strategy for gene-transduced neural and hematopoietic stem/progenitor cells
Hum Gene Ther, 16 (6), 711-24
DOI 10.1089/hum.2005.16.711, PubMed 15960602
Efficient expansion and gene transduction of mouse neural stem/progenitor cells on recombinant fibronectin
Neuroscience, 124 (4), 823-30
DOI 10.1016/j.neuroscience.2003.11.030, PubMed 15026123
Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells
Pharm Res, 20 (6), 904-9
DOI 10.1023/a:1023895404929, PubMed 12817896
Retroviral transfer of MRP1 and gamma-glutamyl cysteine synthetase modulates cell sensitivity to L-buthionine-S,R-sulphoximine (BSO): new rationale for the use of BSO in cancer therapy
Eur J Cancer, 39 (1), 120-8
DOI 10.1016/s0959-8049(02)00447-1, PubMed 12504668
Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice
Biochem Biophys Res Commun, 291 (3), 617-22
DOI 10.1006/bbrc.2002.6489, PubMed 11855834
Role of the multidrug resistance protein 1 gene in the carcinogenicity of aflatoxin B1: investigations using mrp1-null mice
Toxicology, 171 (2-3), 201-5
DOI 10.1016/s0300-483x(01)00584-4, PubMed 11836025
Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents
Hum Gene Ther, 12 (14), 1785-96
DOI 10.1089/104303401750476276, PubMed 11560771
Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis
Blood Cells Mol Dis, 27 (1), 165-80
DOI 10.1006/bcmd.2000.0357, PubMed 11358378
Novobiocin-induced VP-16 accumulation and MRP expression in human leukemia and ovarian carcinoma cells
Anticancer Drug Des, 15 (2), 127-34
PubMed 10901300
Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16)
Oncol Res, 12 (3), 113-9
DOI 10.3727/096504001108747585, PubMed 11216669
Phase I and pharmacokinetic study of novobiocin in combination with VP-16 in patients with refractory malignancies
Cancer J, 6 (4), 256-65
PubMed 11038146
New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models
Biochem Pharmacol, 58 (4), 557-62
DOI 10.1016/s0006-2952(99)00074-x, PubMed 10413292
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins
Cancer Res, 57 (23), 5232-7
PubMed 9393740
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione
Cancer Res, 57 (23), 5238-42
PubMed 9393741
Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase
Biochem Pharmacol, 54 (6), 649-55
DOI 10.1016/s0006-2952(97)00210-4, PubMed 9310341
Altered efflux properties of mouse leukemia L1210 cells resistant to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone
Anticancer Res, 17 (5A), 3185-93
PubMed 9413147
Double knockout of the MRP gene leads to increased drug sensitivity in vitro
Cancer Res, 56 (23), 5351-5
PubMed 8968083
Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene
Cancer Res, 55 (19), 4352-60
PubMed 7671247
Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo
Adv Enzyme Regul, 35, 55-68
DOI 10.1016/0065-2571(94)00005-n, PubMed 7572354
Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones
Biochem Pharmacol, 48 (2), 335-44
DOI 10.1016/0006-2952(94)90105-8, PubMed 8053929
Reversal of etoposide resistance in non-P-glycoprotein expressing multidrug resistant tumor cell lines by novobiocin
Cancer Res, 53 (22), 5487-93
PubMed 8106148
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II
Eur J Cancer, 29A (14), 1985-91
DOI 10.1016/0959-8049(93)90459-s, PubMed 8280493
Novobiocin-induced accumulation of etoposide (VP-16) in WEHI-3B D+ leukemia cells
Int J Cancer, 52 (6), 903-9
DOI 10.1002/ijc.2910520613, PubMed 1334054
Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26)
Int J Cancer, 51 (5), 780-7
DOI 10.1002/ijc.2910510519, PubMed 1377186
Development and characterization of a WEHI-3B D+ monomyelocytic leukemia cell line resistant to novobiocin and cross-resistant to other topoisomerase II-targeted drugs
Cancer Res, 52 (10), 2782-90
PubMed 1316227
Potentiation of etoposide cytotoxicity against a human ovarian cancer cell line by pretreatment with non-toxic concentrations of methotrexate or aphidicolin
Eur J Cancer, 28 (1), 66-71
DOI 10.1016/0959-8049(92)90387-h, PubMed 1314631
Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines
Cancer Res, 51 (19), 5275-83
PubMed 1717144
Induction of the differentiation of WEHI-3B D+ monomyelocytic leukemia cells by inhibitors of topoisomerase II
Cancer Res, 50 (20), 6723-30
PubMed 2170008
Increase in topoisomerase-II-mediated DNA breaks and cytotoxicity of VP16 in human U937 lymphoma cells pretreated with low doses of methotrexate
Int J Cancer, 45 (1), 156-62
DOI 10.1002/ijc.2910450128, PubMed 2153635
Effect of hemin-induced differentiation on chemosensitivity of K 562 leukemia cells
J Chemother, 1 (4 Suppl), 1157-8
PubMed 16312814
Early DNA damage induced in cells exposed to N10-propargyl 5,8-dideazafolic acid (CB 3717) or methotrexate
Biochem Pharmacol, 37 (9), 1875-6
DOI 10.1016/0006-2952(88)90490-x, PubMed 3377859
Increase in etoposide-induced topoisomerase II-mediated DNA breaks after cell synchronization induced by low doses of methotrexate
Biochem Pharmacol, 37 (9), 1883-4
DOI 10.1016/0006-2952(88)90494-7, PubMed 2837248
Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid
Cancer Res, 48 (8), 2036-41
PubMed 3349474
Changes in chemosensitivity of K 562 leukemia cells after induction of erythroid differentiation by hemin
Tumori, 74 (1), 11-7
DOI 10.1177/030089168807400103, PubMed 3162623
Mitozolomide activity on human cancer cells in vitro
Br J Cancer, 54 (6), 925-32
DOI 10.1038/bjc.1986.263, PubMed 3801288
Vitamin E and vitamin C inhibit arachidonate-induced aggregation of human peripheral blood leukocytes in vitro
Agents Actions, 19 (1-2), 127-31
DOI 10.1007/BF01977268, PubMed 3099558
Gentisic acid: an aspirin metabolite with multiple effects on human blood polymorphonuclear leukocytes
Biochem Pharmacol, 35 (14), 2443-5
DOI 10.1016/0006-2952(86)90474-0, PubMed 3015151
Modulation of lymphocyte response by hormones
Acta Eur Fertil, 14 (3), 197-201
PubMed 6670444
Review articles
Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis
Cells, 12 (12)
DOI 10.3390/cells12121566, PubMed 37371036
CD9, a tetraspanin target for cancer therapy?
Exp Biol Med (Maywood), 246 (9), 1121-1138
DOI 10.1177/1535370220981855, PubMed 33601913
Uptake and Fate of Extracellular Membrane Vesicles: Nucleoplasmic Reticulum-Associated Late Endosomes as a New Gate to Intercellular Communication
Cells, 9 (9)
DOI 10.3390/cells9091931, PubMed 32825578
Extracellular Vesicles as Biological Shuttles for Targeted Therapies
Int J Mol Sci, 20 (8)
DOI 10.3390/ijms20081848, PubMed 30991632
Extracellular Vesicles from Thyroid Carcinoma: The New Frontier of Liquid Biopsy
Int J Mol Sci, 20 (5)
DOI 10.3390/ijms20051114, PubMed 30841521
Analogies Between Cancer-Derived Extracellular Vesicles and Enveloped Viruses with an Emphasis on Human Breast Cancer
Curr Pathobiol Rep, 4 (4), 169-179
DOI 10.1007/s40139-016-0116-4, PubMed 32226654
Breast Cancer-Derived Extracellular Vesicles: Characterization and Contribution to the Metastatic Phenotype
Biomed Res Int, 2015, 634865
DOI 10.1155/2015/634865, PubMed 26601108
Other articles
Commentary: Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?
Front Oncol, 11, 712358
DOI 10.3389/fonc.2021.712358, PubMed 34476215
Prominin-1/CD133: Lipid Raft Association, Detergent Resistance, and Immunodetection
Stem Cells Transl Med, 7 (2), 155-160
DOI 10.1002/sctm.17-0223, PubMed 29271118
Observation-driven inquiry: Raman spectroscopic imaging illuminates cancer lipid metabolism
Stem Cell Investig, 4, 42
DOI 10.21037/sci.2017.04.09, PubMed 28607916
Letter to the editor: An intriguing relationship between lipid droplets, cholesterol-binding protein CD133 and Wnt/β-catenin signaling pathway in carcinogenesis
Stem Cells, 33 (4), 1366-70
DOI 10.1002/stem.1953, PubMed 25586989
Transmission of Information in Neoplasia by Extracellular Vesicles
Biomed Res Int, 2015, 289567
DOI 10.1155/2015/289567, PubMed 26697482