Publication list - Publika - Scientific publications from Oslo University Hospital

Publications by Anne Gjøen Simonsen

141 publications found

Original articles

Wang HL, Siow R, Schmauck-Medina T, Zhang J, Sandset PM, Filshie C, Lund Ø, Partridge L, Bergersen LH, Juel Rasmussen L, Palikaras K, Sotiropoulos I, Storm-Mathisen J, Rubinsztein DC, Spillantini MG, De Zeeuw CI, Watne LO, Vyhnalek M, Veverova K, Liang KX, Tavernarakis N, Bohr VA, Yokote K, Saarela J, Nilsen H et al. (2024)
Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
J Gerontol A Biol Sci Med Sci, 79 (4)
DOI 10.1093/gerona/glae029, PubMed 38289789

Sporbeck K, Haas ML, Pastor-Maldonado CJ, Schüssele DS, Hunter C, Takacs Z, Diogo de Oliveira AL, Franz-Wachtel M, Charsou C, Pfisterer SG, Gubas A, Haller PK, Knorr RL, Kaulich M, Macek B, Eskelinen EL, Simonsen A, Proikas-Cezanne T (2023)
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
Commun Biol, 6 (1), 872
DOI 10.1038/s42003-023-05236-9, PubMed 37620393

Kaur N, de la Ballina LR, Haukaas HS, Torgersen ML, Radulovic M, Munson MJ, Sabirsh A, Stenmark H, Simonsen A, Carlsson SR, Lystad AH (2023)
TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy
EMBO J, 42 (17), e113105
DOI 10.15252/embj.2022113105, PubMed 37409525

Rahman MA, Engelsen AST, Sarowar S, Bindesbøll C, Birkeland E, Goplen D, Lotsberg ML, Knappskog S, Simonsen A, Chekenya M (2022)
Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway
Front Cell Dev Biol, 10, 1022191
DOI 10.3389/fcell.2022.1022191, PubMed 36619857

Charsou C, Ng MYW, Simonsen A (2022)
Regulation of autophagosome biogenesis and mitochondrial bioenergetics by the cholesterol transport protein GRAMD1C
Autophagy, 19 (7), 2159-2161
DOI 10.1080/15548627.2022.2155020, PubMed 36469687

Ganley IG, Simonsen A (2022)
Diversity of mitophagy pathways at a glance
J Cell Sci, 135 (23)
DOI 10.1242/jcs.259748, PubMed 36504076

Ng MYW, Charsou C, Lapao A, Singh S, Trachsel-Moncho L, Schultz SW, Nakken S, Munson MJ, Simonsen A (2022)
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics
Nat Commun, 13 (1), 6283
DOI 10.1038/s41467-022-33933-2, PubMed 36270994

Maestro I, de la Ballina LR, Porras G, Corrochano S, De Lago E, Simonsen A, Boya P, Martinez A (2022)
Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations
Int J Mol Sci, 23 (20)
DOI 10.3390/ijms232012676, PubMed 36293534

Reggiori F, Boya P, da Costa D, Elazar Z, Eskelinen EL, Farrés J, Guettler S, Kraft C, Jungbluth H, Martinez A, Morel E, Pless O, Proikas-Cezanne T, Simonsen A (2022)
The mechanism of macroautophagy: The movie
Autophagy Rep, 1 (1), 414-417
DOI 10.1080/27694127.2022.2096115, PubMed 38106995

Xu J, Yang KC, Go NE, Colborne S, Ho CJ, Hosseini-Beheshti E, Lystad AH, Simonsen A, Guns ET, Morin GB, Gorski SM (2022)
Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations
Autophagy, 18 (11), 2547-2560
DOI 10.1080/15548627.2022.2039535, PubMed 35220892

Søreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A (2022)
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration
J Cell Sci, 135 (4)
DOI 10.1242/jcs.259138, PubMed 35099014

Sikkeland J, Ng MYW, Nenseth HZ, Unal B, Qu S, Jin Y, Simonsen A, Saatcioglu F (2022)
STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway
Am J Cancer Res, 12 (1), 327-336
PubMed 35141021

Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, Chang C, Ge L, Schulman BA, Deshaies RJ, Dikic I, Harper JW, Wertz IE, Thomä NH, Słabicki M, Frydman J et al. (2022)
Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report
Ann N Y Acad Sci, 1510 (1), 79-99
DOI 10.1111/nyas.14745, PubMed 35000205

Sharma K, Asp NT, Harrison S, Siller R, Baumgarten SF, Gupta S, Chollet ME, Andersen E, Sullivan GJ, Simonsen A (2021)
Autophagy modulates cell fate decisions during lineage commitment
Autophagy, 18 (8), 1915-1931
DOI 10.1080/15548627.2021.2008691, PubMed 34923909

Maestro I, de la Ballina LR, Simonsen A, Boya P, Martinez A (2021)
Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease
ACS Chem Neurosci, 12 (24), 4512-4523
DOI 10.1021/acschemneuro.1c00529, PubMed 34846852

Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, Tangavelou K, Gudmundsson SR, Ye C, Rusten TE, Anonsen JH, Lystad AH, Claude-Taupin A, Simonsen A, Salemi M, Phinney B, Li J, Guo LW, Bradfute SB, Timmins GS, Eskelinen EL, Deretic V (2021)
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 184 (24), 5950-5969.e22
DOI 10.1016/j.cell.2021.10.017, PubMed 34741801

Giovannucci TA, Salomons FA, Stoy H, Herzog LK, Xu S, Qian W, Merino LG, Gierisch ME, Haraldsson M, Lystad AH, Uvell H, Simonsen A, Gustavsson AL, Vallin M, Dantuma NP (2021)
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy
Autophagy, 18 (7), 1486-1502
DOI 10.1080/15548627.2021.1988359, PubMed 34740308

Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A (2021)
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015

Durgan J, Lystad AH, Sloan K, Carlsson SR, Wilson MI, Marcassa E, Ulferts R, Webster J, Lopez-Clavijo AF, Wakelam MJ, Beale R, Simonsen A, Oxley D, Florey O (2021)
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine
Mol Cell, 81 (9), 2031-2040.e8
DOI 10.1016/j.molcel.2021.03.020, PubMed 33909989

Corkery DP, Nadeem A, Aung KM, Hassan A, Liu T, Cervantes-Rivera R, Lystad AH, Wang H, Persson K, Puhar A, Simonsen A, Uhlin BE, Wai SN, Wu YW (2021)
Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy
J Cell Sci, 134 (5)
DOI 10.1242/jcs.252015, PubMed 33106317

Bindesbøll C, Aas A, Ogmundsdottir MH, Pankiv S, Reine T, Zoncu R, Simonsen A (2020)
NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease
Sci Rep, 10 (1), 4528
DOI 10.1038/s41598-020-61352-0, PubMed 32161285

Lotsberg ML, Wnuk-Lipinska K, Terry S, Tan TZ, Lu N, Trachsel-Moncho L, Røsland GV, Siraji MI, Hellesøy M, Rayford A, Jacobsen K, Ditzel HJ, Vintermyr OK, Bivona TG, Minna J, Brekken RA, Baguley B, Micklem D, Akslen LA, Gausdal G, Simonsen A, Thiery JP, Chouaib S, Lorens JB, Engelsen AST (2020)
AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells
J Thorac Oncol, 15 (6), 973-999
DOI 10.1016/j.jtho.2020.01.015, PubMed 32018052

Gawel K, Turski WA, van der Ent W, Mathai BJ, Kirstein-Smardzewska KJ, Simonsen A, Esguerra CV (2019)
Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene
Mol Neurobiol, 57 (4), 1904-1916
DOI 10.1007/s12035-019-01860-x, PubMed 31875924

Simonsen A, Sánchez-Heredia JD, Saarinen SA, Ardenkjær-Larsen JH, Schliesser A, Polzik ES (2019)
Magnetic resonance imaging with optical preamplification and detection
Sci Rep, 9 (1), 18173
DOI 10.1038/s41598-019-54200-3, PubMed 31796770

Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G, Dikic I (2019)
TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease
EMBO Rep, 21 (1), e48317
DOI 10.15252/embr.201948317, PubMed 31709703

Herzog LK, Kevei É, Marchante R, Böttcher C, Bindesbøll C, Lystad AH, Pfeiffer A, Gierisch ME, Salomons FA, Simonsen A, Hoppe T, Dantuma NP (2019)
The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy
Aging Cell, 19 (1), e13051
DOI 10.1111/acel.13051, PubMed 31625269

Rahman MA, Gras Navarro A, Brekke J, Engelsen A, Bindesbøll C, Sarowar S, Bahador M, Bifulco E, Goplen D, Waha A, Lie SA, Gjertsen BT, Selheim F, Enger PØ, Simonsen A, Chekenya M (2019)
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival
Br J Cancer, 121 (7), 545-555
DOI 10.1038/s41416-019-0551-1, PubMed 31413318

Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sørensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H (2019)
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282

Gras Navarro A, Espedal H, Joseph JV, Trachsel-Moncho L, Bahador M, Gjertsen BT, Kristoffersen EK, Simonsen A, Miletic H, Enger PØ, Rahman MA, Chekenya M (2019)
Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival
Cancers (Basel), 11 (7)
DOI 10.3390/cancers11070996, PubMed 31319548

Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, Liu M, Hall P, Sklar LA, Allers L, Mariscal L, Garcia SA, Weaver J, Baehrecke EH, Behrends C, Cecconi F, Codogno P, Chen GC, Elazar Z, Eskelinen EL, Fourie B, Gozuacik D, Hong W, Jo EK, Johansen T et al. (2019)
Autophagy, Inflammation, and Metabolism (AIM) Center in its second year
Autophagy, 15 (10), 1829-1833
DOI 10.1080/15548627.2019.1634444, PubMed 31234750

Princely Abudu Y, Pankiv S, Mathai BJ, Håkon Lystad A, Bindesbøll C, Brenne HB, Yoke Wui Ng M, Thiede B, Yamamoto A, Mutugi Nthiga T, Lamark T, Esguerra CV, Johansen T, Simonsen A (2019)
NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy
Dev Cell, 49 (4), 509-525.e12
DOI 10.1016/j.devcel.2019.03.013, PubMed 30982665

Chaurasia M, Gupta S, Das A, Dwarakanath BS, Simonsen A, Sharma K (2019)
Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy
Autophagy, 15 (8), 1391-1406
DOI 10.1080/15548627.2019.1582973, PubMed 30773986

Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A (2019)
Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes
Nat Cell Biol, 21 (3), 372-383
DOI 10.1038/s41556-019-0274-9, PubMed 30778222

Möller K, Sigurbjornsdottir S, Arnthorsson AO, Pogenberg V, Dilshat R, Fock V, Brynjolfsdottir SH, Bindesboll C, Bessadottir M, Ogmundsdottir HM, Simonsen A, Larue L, Wilmanns M, Thorsson V, Steingrimsson E, Ogmundsdottir MH (2019)
MITF has a central role in regulating starvation-induced autophagy in melanoma
Sci Rep, 9 (1), 1055
DOI 10.1038/s41598-018-37522-6, PubMed 30705290

Johannessen TC, Hasan-Olive MM, Zhu H, Denisova O, Grudic A, Latif MA, Saed H, Varughese JK, Røsland GV, Yang N, Sundstrøm T, Nordal A, Tronstad KJ, Wang J, Lund-Johansen M, Simonsen A, Janji B, Westermarck J, Bjerkvig R, Prestegarden L (2018)
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide
Int J Cancer, 144 (7), 1735-1745
DOI 10.1002/ijc.31912, PubMed 30289977

Ogmundsdottir MH, Fock V, Sooman L, Pogenberg V, Dilshat R, Bindesbøll C, Ogmundsdottir HM, Simonsen A, Wilmanns M, Steingrimsson E (2018)
A short isoform of ATG7 fails to lipidate LC3/GABARAP
Sci Rep, 8 (1), 14391
DOI 10.1038/s41598-018-32694-7, PubMed 30258106

Kraft C, Boya P, Codogno P, Elazar Z, Eskelinen EL, Farrés J, Kirkin V, Jungbluth H, Martinez A, Pless O, Primard C, Proikas-Cezanne T, Simonsen A, Reggiori F (2018)
Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy
Autophagy, 15 (2), 347-351
DOI 10.1080/15548627.2018.1515532, PubMed 30176150

Skah S, Richartz N, Duthil E, Gilljam KM, Bindesbøll C, Naderi EH, Eriksen AB, Ruud E, Dirdal MM, Simonsen A, Blomhoff HK (2018)
cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53
Oncotarget, 9 (54), 30434-30449
DOI 10.18632/oncotarget.25758, PubMed 30100998

SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H (2018)
Publisher Correction: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
Nat Commun, 9, 16206
DOI 10.1038/ncomms16206, PubMed 29595188

Søreng K, Munson MJ, Lamb CA, Bjørndal GT, Pankiv S, Carlsson SR, Tooze SA, Simonsen A (2018)
SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2
EMBO Rep, 19 (4)
DOI 10.15252/embr.201744837, PubMed 29437695

Schläfli AM, Isakson P, Garattini E, Simonsen A, Tschan MP (2017)
The autophagy scaffold protein ALFY is critical for the granulocytic differentiation of AML cells
Sci Rep, 7 (1), 12980
DOI 10.1038/s41598-017-12734-4, PubMed 29021535

Kjos I, Borg Distefano M, Sætre F, Repnik U, Holland P, Jones AT, Engedal N, Simonsen A, Bakke O, Progida C (2017)
Rab7b modulates autophagic flux by interacting with Atg4B
EMBO Rep, 18 (10), 1727-1739
DOI 10.15252/embr.201744069, PubMed 28835545

Aas A, Isakson P, Bindesbøll C, Alemu EA, Klungland A, Simonsen A (2017)
Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy
PLoS One, 12 (3), e0168182
DOI 10.1371/journal.pone.0168182, PubMed 28288181

Holland P, Knævelsrud H, Søreng K, Mathai BJ, Lystad AH, Pankiv S, Bjørndal GT, Schultz SW, Lobert VH, Chan RB, Zhou B, Liestøl K, Carlsson SR, Melia TJ, Di Paolo G, Simonsen A (2016)
HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
Nat Commun, 7, 13889
DOI 10.1038/ncomms13889, PubMed 28004827

Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A (2016)
Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain
Elife, 5
DOI 10.7554/eLife.14810, PubMed 27648578

Andersen AN, Landsverk OJ, Simonsen A, Bogen B, Corthay A, Øynebråten I (2016)
Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity
Front Immunol, 7, 167
DOI 10.3389/fimmu.2016.00167, PubMed 27242780

Mamińska A, Bartosik A, Banach-Orłowska M, Pilecka I, Jastrzębski K, Zdżalik-Bielecka D, Castanon I, Poulain M, Neyen C, Wolińska-Nizioł L, Toruń A, Szymańska E, Kowalczyk A, Piwocka K, Simonsen A, Stenmark H, Fürthauer M, González-Gaitán M, Miaczynska M (2016)
ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors
Sci Signal, 9 (411), ra8
DOI 10.1126/scisignal.aad0848, PubMed 26787452

Ylä-Anttila P, Mikkonen E, Happonen KE, Holland P, Ueno T, Simonsen A, Eskelinen EL (2015)
RAB24 facilitates clearance of autophagic compartments during basal conditions
Autophagy, 11 (10), 1833-48
DOI 10.1080/15548627.2015.1086522, PubMed 26325487

Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B (2015)
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Autophagy, 11 (9), 1458-70
DOI 10.1080/15548627.2015.1067359, PubMed 26207339

Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B (2015)
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells
Autophagy, 11 (9), 1471-83
DOI 10.1080/15548627.2015.1068488, PubMed 26213203

Eriksen AB, Torgersen ML, Holm KL, Abrahamsen G, Spurkland A, Moskaug JØ, Simonsen A, Blomhoff HK (2015)
Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy
Autophagy, 11 (3), 460-71
DOI 10.1080/15548627.2015.1009797, PubMed 25749095

Lystad AH, Simonsen A (2014)
Assays to monitor aggrephagy
Methods, 75, 112-9
DOI 10.1016/j.ymeth.2014.12.019, PubMed 25555675

Holland P, Torgersen ML, Sandvig K, Simonsen A (2014)
LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis
Traffic, 15 (12), 1390-405
DOI 10.1111/tra.12227, PubMed 25216107

Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Münch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V (2014)
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition
Dev Cell, 30 (4), 394-409
DOI 10.1016/j.devcel.2014.06.013, PubMed 25127057

Lystad AH, Ichimura Y, Takagi K, Yang Y, Pankiv S, Kanegae Y, Kageyama S, Suzuki M, Saito I, Mizushima T, Komatsu M, Simonsen A (2014)
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures
EMBO Rep, 15 (5), 557-65
DOI 10.1002/embr.201338003, PubMed 24668264

Bagci T, Simonsen A, Schmid S, Villanueva LG, Zeuthen E, Appel J, Taylor JM, Sørensen A, Usami K, Schliesser A, Polzik ES (2014)
Optical detection of radio waves through a nanomechanical transducer
Nature, 507 (7490), 81-5
DOI 10.1038/nature13029, PubMed 24598636

Isakson P, Lystad AH, Breen K, Koster G, Stenmark H, Simonsen A (2013)
TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy
Autophagy, 9 (12), 1955-64
DOI 10.4161/auto.26085, PubMed 24128730

Torgersen ML, Engedal N, Bøe SO, Hokland P, Simonsen A (2013)
Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells
Blood, 122 (14), 2467-76
DOI 10.1182/blood-2013-05-500629, PubMed 23970379

Engedal N, Torgersen ML, Guldvik IJ, Barfeld SJ, Bakula D, Sætre F, Hagen LK, Patterson JB, Proikas-Cezanne T, Seglen PO, Simonsen A, Mills IG (2013)
Modulation of intracellular calcium homeostasis blocks autophagosome formation
Autophagy, 9 (10), 1475-90
DOI 10.4161/auto.25900, PubMed 23970164

Knævelsrud H, Søreng K, Raiborg C, Håberg K, Rasmuson F, Brech A, Liestøl K, Rusten TE, Stenmark H, Neufeld TP, Carlsson SR, Simonsen A (2013)
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation
J Cell Biol, 202 (2), 331-49
DOI 10.1083/jcb.201205129, PubMed 23878278

SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H (2013)
Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
Nat Commun, 4, 2674
DOI 10.1038/ncomms3674, PubMed 24154628

Lång E, Grudic A, Pankiv S, Bruserud O, Simonsen A, Bjerkvig R, Bjørås M, Bøe SO (2012)
The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling
Blood, 120 (4), 847-57
DOI 10.1182/blood-2011-10-388496, PubMed 22692509

Reggiori F, Komatsu M, Finley K, Simonsen A (2012)
Autophagy: more than a nonselective pathway
Int J Cell Biol, 2012, 219625
DOI 10.1155/2012/219625, PubMed 22666256

Reggiori F, Komatsu M, Finley K, Simonsen A (2012)
Selective types of autophagy
Int J Cell Biol, 2012, 156272
DOI 10.1155/2012/156272, PubMed 22956958

Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, Harris GL, Nezis IP, Schubert DR, Simonsen A, Finley KD (2011)
p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects
Autophagy, 7 (6), 572-83
DOI 10.4161/auto.7.6.14943, PubMed 21325881

Yamamoto A, Simonsen A (2011)
Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?
Autophagy, 7 (3), 346-50
DOI 10.4161/auto.7.3.14234, PubMed 21150266

Knævelsrud H, Ahlquist T, Merok MA, Nesbakken A, Stenmark H, Lothe RA, Simonsen A (2010)
UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
Autophagy, 6 (7), 863-70
DOI 10.4161/auto.6.7.13033, PubMed 20724836

Isakson P, Bjørås M, Bøe SO, Simonsen A (2010)
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
Blood, 116 (13), 2324-31
DOI 10.1182/blood-2010-01-261040, PubMed 20574048

Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia TJ, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A (2010)
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
Mol Cell, 38 (2), 265-79
DOI 10.1016/j.molcel.2010.04.007, PubMed 20417604

Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A, Johansen T (2010)
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
Autophagy, 6 (3), 330-44
DOI 10.4161/auto.6.3.11226, PubMed 20168092

Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, Contamine D, Rusten TE, Stenmark H, Brech A (2008)
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
J Cell Biol, 180 (6), 1065-71
DOI 10.1083/jcb.200711108, PubMed 18347073

Rusten TE, Filimonenko M, Rodahl LM, Stenmark H, Simonsen A (2008)
ESCRTing autophagic clearance of aggregating proteins
Autophagy, 4 (2), 233-236
DOI 10.4161/auto.5396

Rusten TE, Simonsen A (2008)
ESCRT functions in autophagy and associated disease
Cell Cycle, 7 (9), 1166-72
DOI 10.4161/cc.7.9.5784, PubMed 18418046

Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD (2007)
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
Autophagy, 4 (2), 176-84
DOI 10.4161/auto.5269, PubMed 18059160

Filimonenko M, Stuffers S, Raiborg C, Yamamoto A, Malerød L, Fisher EM, Isaacs A, Brech A, Stenmark H, Simonsen A (2007)
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
J Cell Biol, 179 (3), 485-500
DOI 10.1083/jcb.200702115, PubMed 17984323

Simonsen A, Cumming RC, Lindmo K, Galaviz V, Cheng S, Rusten TE, Finley KD (2007)
Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles
Genetics, 176 (2), 1283-97
DOI 10.1534/genetics.106.065011, PubMed 17435236

Simonsen A, Cumming RC, Finley KD (2007)
Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila
Autophagy, 3 (5), 499-501
DOI 10.4161/auto.4604, PubMed 17617737

Norlén L, Gil IP, Simonsen A, Descouts P (2006)
Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films
J Struct Biol, 158 (3), 386-400
DOI 10.1016/j.jsb.2006.12.006, PubMed 17287132

Lindmo K, Simonsen A, Brech A, Finley K, Rusten TE, Stenmark H (2006)
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body
Exp Cell Res, 312 (11), 2018-27
DOI 10.1016/j.yexcr.2006.03.002, PubMed 16600212

Simonsen A, Birkeland HC, Gillooly DJ, Mizushima N, Kuma A, Yoshimori T, Slagsvold T, Brech A, Stenmark H (2004)
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
J Cell Sci, 117 (Pt 18), 4239-51
DOI 10.1242/jcs.01287, PubMed 15292400

Storen T, Simonsen A, Royset AK, Lokberg OJ, Svaasand LO, Lindmo T (2003)
Time resolved spectroscopic optical coherence tomography for diffusion measurements
P SOC PHOTO-OPT INS, 4956, 197-204
DOI 10.1117/12.477645

Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, Stenmark H, Olkkonen VM (2002)
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking
J Cell Sci, 115 (Pt 5), 899-911
DOI 10.1242/jcs.115.5.899, PubMed 11870209

Simonsen A, Stenmark H (2001)
PX domains: attracted by phosphoinositides
Nat Cell Biol, 3 (8), E179-82
DOI 10.1038/35087112, PubMed 11483972

Prosch-Danielsen L, Simonsen A (2000)
Palaeoecological investigations towards the reconstruction of the history of forest clearances and coastal heathlands in south-western Norway
Veg. Hist. Archaeobot., 9 (4), 189-204
DOI 10.1007/BF01294634

Simonsen A, Gaullier JM, D'Arrigo A, Stenmark H (1999)
The Rab5 effector EEA1 interacts directly with syntaxin-6
J Biol Chem, 274 (41), 28857-60
DOI 10.1074/jbc.274.41.28857, PubMed 10506127

Simonsen A, Pedersen KW, Nordeng TW, von der Lippe A, Stang E, Long EO, Bakke O (1999)
Polarized transport of MHC class II molecules in Madin-Darby canine kidney cells is directed by a leucine-based signal in the cytoplasmic tail of the beta-chain
J Immunol, 163 (5), 2540-8
PubMed 10452991

Gaullier JM, Gillooly D, Simonsen A, Stenmark H (1999)
Regulation of endocytic membrane traffic by phosphatidylinositol 3-phosphate
Biochem Soc Trans, 27 (4), 666-70
DOI 10.1042/bst0270666, PubMed 10917663

Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H (1999)
FYVE finger proteins as effectors of phosphatidylinositol 3-phosphate
Chem Phys Lipids, 98 (1-2), 87-94
DOI 10.1016/s0009-3084(99)00021-3, PubMed 10358931

Callaghan J, Simonsen A, Gaullier JM, Toh BH, Stenmark H (1999)
The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer
Biochem J, 338 ( Pt 2) (Pt 2), 539-43
DOI 10.1042/0264-6021:3380539, PubMed 10024533

Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H (1998)
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
Nature, 394 (6692), 494-8
DOI 10.1038/28879, PubMed 9697774

Simonsen A, Bremnes B, Nordeng TW, Bakke O (1998)
The leucine-based motif DDQxxLI is recognized both for internalization and basolateral sorting of invariant chain in MDCK cells
Eur J Cell Biol, 76 (1), 25-32
DOI 10.1016/S0171-9335(98)80014-9, PubMed 9650780

Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (1998)
Syntaxin-16, a putative Golgi t-SNARE
Eur J Cell Biol, 75 (3), 223-31
DOI 10.1016/S0171-9335(98)80116-7, PubMed 9587053

Simonsen A, Stang E, Bremnes B, Røe M, Prydz K, Bakke O (1997)
Sorting of MHC class II molecules and the associated invariant chain (Ii) in polarized MDCK cells
J Cell Sci, 110 ( Pt 5), 597-609
DOI 10.1242/jcs.110.5.597, PubMed 9092942

Simonsen A, Momburg F, Drexler J, Hämmerling GJ, Bakke O (1993)
Intracellular distribution of the MHC class II molecules and the associated invariant chain (Ii) in different cell lines
Int Immunol, 5 (8), 903-17
DOI 10.1093/intimm/5.8.903, PubMed 8398985

Review articles

Simonsen A, Wollert T (2022)
Don't forget to be picky - selective autophagy of protein aggregates in neurodegenerative diseases
Curr Opin Cell Biol, 75, 102064
DOI 10.1016/j.ceb.2022.01.009, PubMed 35240373

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T et al. (2021)
Autophagy in major human diseases
EMBO J, 40 (19), e108863
DOI 10.15252/embj.2021108863, PubMed 34459017

Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF (2021)
Autophagy in healthy aging and disease
Nat Aging, 1 (8), 634-650
DOI 10.1038/s43587-021-00098-4, PubMed 34901876

Ng MYW, Wai T, Simonsen A (2021)
Quality control of the mitochondrion
Dev Cell, 56 (7), 881-905
DOI 10.1016/j.devcel.2021.02.009, PubMed 33662258

Terešak P, Lapao A, Subic N, Boya P, Elazar Z, Simonsen A (2021)
Regulation of PRKN-independent mitophagy
Autophagy, 18 (1), 24-39
DOI 10.1080/15548627.2021.1888244, PubMed 33570005

Melia TJ, Lystad AH, Simonsen A (2020)
Autophagosome biogenesis: From membrane growth to closure
J Cell Biol, 219 (6)
DOI 10.1083/jcb.202002085, PubMed 32357219

Lystad AH, Simonsen A (2019)
Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery
Cells, 8 (9)
DOI 10.3390/cells8090973, PubMed 31450711

de la Ballina LR, Munson MJ, Simonsen A (2019)
Lipids and Lipid-Binding Proteins in Selective Autophagy
J Mol Biol, 432 (1), 135-159
DOI 10.1016/j.jmb.2019.05.051, PubMed 31202884

Søreng K, Neufeld TP, Simonsen A (2017)
Membrane Trafficking in Autophagy
Int Rev Cell Mol Biol, 336, 1-92
DOI 10.1016/bs.ircmb.2017.07.001, PubMed 29413888

Mathai BJ, Meijer AH, Simonsen A (2017)
Studying Autophagy in Zebrafish
Cells, 6 (3)
DOI 10.3390/cells6030021, PubMed 28698482

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC et al. (2017)
Molecular definitions of autophagy and related processes
EMBO J, 36 (13), 1811-1836
DOI 10.15252/embj.201796697, PubMed 28596378

Shatz O, Holland P, Elazar Z, Simonsen A (2016)
Complex Relations Between Phospholipids, Autophagy, and Neutral Lipids
Trends Biochem Sci, 41 (11), 907-923
DOI 10.1016/j.tibs.2016.08.001, PubMed 27595473

Lystad AH, Simonsen A (2016)
Phosphoinositide-binding proteins in autophagy
FEBS Lett, 590 (15), 2454-68
DOI 10.1002/1873-3468.12286, PubMed 27391591

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM et al. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652

Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G (2015)
Autophagy in malignant transformation and cancer progression
EMBO J, 34 (7), 856-80
DOI 10.15252/embj.201490784, PubMed 25712477

Isakson P, Holland P, Simonsen A (2012)
The role of ALFY in selective autophagy
Cell Death Differ, 20 (1), 12-20
DOI 10.1038/cdd.2012.66, PubMed 22653340

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A et al. (2012)
Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy, 8 (4), 445-544
DOI 10.4161/auto.19496, PubMed 22966490

Knævelsrud H, Simonsen A (2012)
Lipids in autophagy: constituents, signaling molecules and cargo with relevance to disease
Biochim Biophys Acta, 1821 (8), 1133-45
DOI 10.1016/j.bbalip.2012.01.001, PubMed 22269166

Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia TJ, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA (2011)
A comprehensive glossary of autophagy-related molecules and processes (2nd edition)
Autophagy, 7 (11), 1273-94
DOI 10.4161/auto.7.11.17661, PubMed 21997368

Yamamoto A, Simonsen A (2010)
The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration
Neurobiol Dis, 43 (1), 17-28
DOI 10.1016/j.nbd.2010.08.015, PubMed 20732422

Knaevelsrud H, Simonsen A (2010)
Fighting disease by selective autophagy of aggregate-prone proteins
FEBS Lett, 584 (12), 2635-45
DOI 10.1016/j.febslet.2010.04.041, PubMed 20412801

Simonsen A, Tooze SA (2009)
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
J Cell Biol, 186 (6), 773-82
DOI 10.1083/jcb.200907014, PubMed 19797076

Cumming RC, Simonsen A, Finley KD (2008)
Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates
Methods Enzymol, 451, 639-51
DOI 10.1016/S0076-6879(08)03235-7, PubMed 19185743

Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y et al. (2007)
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Autophagy, 4 (2), 151-75
DOI 10.4161/auto.5338, PubMed 18188003

Gillooly DJ, Simonsen A, Stenmark H (2001)
Phosphoinositides and phagocytosis
J Cell Biol, 155 (1), 15-7
DOI 10.1083/jcb.200109001, PubMed 11581282

Simonsen A, Wurmser AE, Emr SD, Stenmark H (2001)
The role of phosphoinositides in membrane transport
Curr Opin Cell Biol, 13 (4), 485-92
DOI 10.1016/s0955-0674(00)00240-4, PubMed 11454456

Gillooly DJ, Simonsen A, Stenmark H (2001)
Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins
Biochem J, 355 (Pt 2), 249-58
DOI 10.1042/0264-6021:3550249, PubMed 11284710