Publication list - Publika - Scientific publications from Oslo University Hospital

Publications by Maria Lyngaas Torgersen

59 publications found

Original articles

Kuczkowska K, Bjerkan L, Stubsrud E, Husbyn HC, Chellappa S, Hauge A, Skarshaug R, Torgersen ML, Heim JB, Jørgensen MJ, Wold CW, Schleimann MH, Tolstrup M, Granum S, Fredriksen AB, Pedersen MW, Norheim G (2023)
A novel SARS-CoV-2 Beta RBD DNA vaccine directly targeted to antigen-presenting cells induces strong humoral and T cell responses
Sci Rep, 13 (1), 18902
DOI 10.1038/s41598-023-46223-8, PubMed 37919366

Nähse V, Raiborg C, Tan KW, Mørk S, Torgersen ML, Wenzel EM, Nager M, Salo VT, Johansen T, Ikonen E, Schink KO, Stenmark H (2023)
ATPase activity of DFCP1 controls selective autophagy
Nat Commun, 14 (1), 4051
DOI 10.1038/s41467-023-39641-9, PubMed 37422481

Kaur N, de la Ballina LR, Haukaas HS, Torgersen ML, Radulovic M, Munson MJ, Sabirsh A, Stenmark H, Simonsen A, Carlsson SR, Lystad AH (2023)
TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy
EMBO J, 42 (17), e113105
DOI 10.15252/embj.2022113105, PubMed 37409525

Engedal N, Sønstevold T, Beese CJ, Selladurai S, Melcher T, Simensen JE, Frankel LB, Urbanucci A, Torgersen ML (2022)
Measuring Autophagic Cargo Flux with Keima-Based Probes
Methods Mol Biol, 2445, 99-115
DOI 10.1007/978-1-0716-2071-7_7, PubMed 34972988

Sønstevold T, Engedal N, Torgersen ML (2021)
Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy
Cells, 10 (12)
DOI 10.3390/cells10123432, PubMed 34943939

Øverbye A, Torgersen ML, Sønstevold T, Iversen TG, Mørch Ý, Skotland T, Sandvig K (2021)
Cabazitaxel-loaded poly(alkyl cyanoacrylate) nanoparticles: toxicity and changes in the proteome of breast, colon and prostate cancer cells
Nanotoxicology, 15 (7), 865-884
DOI 10.1080/17435390.2021.1924888, PubMed 34047629

Valsalakumari R, Yadava SK, Szwed M, Pandya AD, Mælandsmo GM, Torgersen ML, Iversen TG, Skotland T, Sandvig K, Giri J (2021)
Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells
Int J Pharm, 597, 120217
DOI 10.1016/j.ijpharm.2021.120217, PubMed 33486035

Torgersen ML, Judge PJ, Bada Juarez JF, Pandya AD, Fusser M, Davies CW, Maciejewska MK, Yin DJ, Maelandsmo GM, Skotland T, Watts A, Sandvig K (2020)
Physicochemical Characterization, Toxicity and In Vivo Biodistribution Studies of a Discoidal, Lipid-Based Drug Delivery Vehicle: Lipodisq Nanoparticles Containing Doxorubicin
J Biomed Nanotechnol, 16 (4), 419-431
DOI 10.1166/jbn.2020.2911, PubMed 32970975

Sønstevold T, Engedal N, Mørch Ý, Iversen TG, Skotland T, Sandvig K, Torgersen ML (2020)
Structural Variants of poly(alkylcyanoacrylate) Nanoparticles Differentially Affect LC3 and Autophagic Cargo Degradation
J Biomed Nanotechnol, 16 (4), 432-445
DOI 10.1166/jbn.2020.2906, PubMed 32970976

Solhaug A, Torgersen ML, Holme JA, Wiik-Nilsen J, Thiede B, Eriksen GS (2020)
The Fusarium mycotoxin, 2-Amino-14,16-dimethyloctadecan-3-ol (AOD) induces vacuolization in HepG2 cells
Toxicology, 433-434, 152405
DOI 10.1016/j.tox.2020.152405, PubMed 32044396

Szwed M, Torgersen ML, Kumari RV, Yadava SK, Pust S, Iversen TG, Skotland T, Giri J, Sandvig K (2020)
Biological response and cytotoxicity induced by lipid nanocapsules
J Nanobiotechnology, 18 (1), 5
DOI 10.1186/s12951-019-0567-y, PubMed 31907052

Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N (2019)
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
J Biol Chem, 294 (20), 8197-8217
DOI 10.1074/jbc.RA118.002829, PubMed 30926605

Szwed M, Sønstevold T, Øverbye A, Engedal N, Grallert B, Mørch Ý, Sulheim E, Iversen TG, Skotland T, Sandvig K, Torgersen ML (2019)
Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death
Nanotoxicology, 13 (6), 761-782
DOI 10.1080/17435390.2019.1576238, PubMed 30760074

SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H (2018)
Publisher Correction: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
Nat Commun, 9, 16206
DOI 10.1038/ncomms16206, PubMed 29595188

Zmajkovic J, Lundberg P, Nienhold R, Torgersen ML, Sundan A, Waage A, Skoda RC (2018)
A Gain-of-Function Mutation in EPO in Familial Erythrocytosis
N Engl J Med, 378 (10), 924-930
DOI 10.1056/NEJMoa1709064, PubMed 29514032

Hong Z, Pedersen NM, Wang L, Torgersen ML, Stenmark H, Raiborg C (2017)
PtdIns3P controls mTORC1 signaling through lysosomal positioning
J Cell Biol, 216 (12), 4217-4233
DOI 10.1083/jcb.201611073, PubMed 29030394

Øverbye A, Holsæter AM, Markus F, Škalko-Basnet N, Iversen TG, Torgersen ML, Sønstevold T, Engebraaten O, Flatmark K, Mælandsmo GM, Skotland T, Sandvig K (2017)
Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide
Oncotarget, 8 (44), 76921-76934
DOI 10.18632/oncotarget.20217, PubMed 29100358

Manna D, Pust S, Torgersen ML, Cordara G, Künzler M, Krengel U, Sandvig K (2017)
Polyporus squamosus Lectin 1a (PSL1a) Exhibits Cytotoxicity in Mammalian Cells by Disruption of Focal Adhesions, Inhibition of Protein Synthesis and Induction of Apoptosis
PLoS One, 12 (1), e0170716
DOI 10.1371/journal.pone.0170716, PubMed 28114329

Torgersen ML, Klokk TI, Kavaliauskiene S, Klose C, Simons K, Skotland T, Sandvig K (2016)
The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport
Oncotarget, 7 (52), 86871-86888
DOI 10.18632/oncotarget.13508, PubMed 27894086

Kavaliauskiene S, Torgersen ML, Lingelem AB, Klokk TI, Lintonen T, Simolin H, Ekroos K, Skotland T, Sandvig K (2016)
Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport
Oncotarget, 7 (48), 79885-79900
DOI 10.18632/oncotarget.13089, PubMed 27829218

Hessvik NP, Øverbye A, Brech A, Torgersen ML, Jakobsen IS, Sandvig K, Llorente A (2016)
PIKfyve inhibition increases exosome release and induces secretory autophagy
Cell Mol Life Sci, 73 (24), 4717-4737
DOI 10.1007/s00018-016-2309-8, PubMed 27438886

Kavaliauskiene S, Skotland T, Sylvänne T, Simolin H, Klokk TI, Torgersen ML, Lingelem AB, Simm R, Ekroos K, Sandvig K (2015)
Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids
Biochem J, 470 (1), 23-37
DOI 10.1042/BJ20141562, PubMed 26251444

Dyve Lingelem AB, Hjelseth IA, Simm R, Torgersen ML, Sandvig K (2015)
Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells
PLoS One, 10 (5), e0129214
DOI 10.1371/journal.pone.0129214, PubMed 26017782

Naderi EH, Skah S, Ugland H, Myklebost O, Sandnes DL, Torgersen ML, Josefsen D, Ruud E, Naderi S, Blomhoff HK (2015)
Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death
Mol Cancer, 14 (1), 14
DOI 10.1186/s12943-014-0278-9, PubMed 25623255

Eriksen AB, Torgersen ML, Holm KL, Abrahamsen G, Spurkland A, Moskaug JØ, Simonsen A, Blomhoff HK (2015)
Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy
Autophagy, 11 (3), 460-71
DOI 10.1080/15548627.2015.1009797, PubMed 25749095

Solhaug A, Torgersen ML, Holme JA, Lagadic-Gossmann D, Eriksen GS (2014)
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol
Toxicology, 326, 119-29
DOI 10.1016/j.tox.2014.10.009, PubMed 25456271

Holland P, Torgersen ML, Sandvig K, Simonsen A (2014)
LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis
Traffic, 15 (12), 1390-405
DOI 10.1111/tra.12227, PubMed 25216107

Torgersen ML, Engedal N, Bøe SO, Hokland P, Simonsen A (2013)
Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells
Blood, 122 (14), 2467-76
DOI 10.1182/blood-2013-05-500629, PubMed 23970379

Engedal N, Torgersen ML, Guldvik IJ, Barfeld SJ, Bakula D, Sætre F, Hagen LK, Patterson JB, Proikas-Cezanne T, Seglen PO, Simonsen A, Mills IG (2013)
Modulation of intracellular calcium homeostasis blocks autophagosome formation
Autophagy, 9 (10), 1475-90
DOI 10.4161/auto.25900, PubMed 23970164

Follin-Arbelet V, Torgersen ML, Naderi EH, Misund K, Sundan A, Blomhoff HK (2013)
Death of multiple myeloma cells induced by cAMP-signaling involves downregulation of Mcl-1 via the JAK/STAT pathway
Cancer Lett, 335 (2), 323-31
DOI 10.1016/j.canlet.2013.02.042, PubMed 23454584

SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H (2013)
Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
Nat Commun, 4, 2674
DOI 10.1038/ncomms3674, PubMed 24154628

Torgersen ML, Engedal N, Pedersen AM, Husebye H, Espevik T, Sandvig K (2010)
Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells
FEMS Immunol Med Microbiol, 61 (1), 63-75
DOI 10.1111/j.1574-695X.2010.00749.x, PubMed 21054580

Torgersen ML, Engedal N, Bergan J, Sandvig K (2010)
The Intracellular Journey of Shiga Toxins
The Open Toxinology Journal, 3, 3-12
PublikaID 24

Pust S, Dyve AB, Torgersen ML, van Deurs B, Sandvig K (2010)
Interplay between toxin transport and flotillin localization
PLoS One, 5 (1), e8844
DOI 10.1371/journal.pone.0008844, PubMed 20107503

Sandvig K, Bergan J, Dyve AB, Skotland T, Torgersen ML (2009)
Endocytosis and retrograde transport of Shiga toxin
Toxicon, 56 (7), 1181-5
DOI 10.1016/j.toxicon.2009.11.021, PubMed 19951719

Wälchli S, Aasheim HC, Skånland SS, Spilsberg B, Torgersen ML, Rosendal KR, Sandvig K (2009)
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell Signal, 21 (7), 1161-8
DOI 10.1016/j.cellsig.2009.03.005, PubMed 19289168

Wälchli S, Skånland SS, Gregers TF, Lauvrak SU, Torgersen ML, Ying M, Kuroda S, Maturana A, Sandvig K (2007)
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking
Mol Biol Cell, 19 (1), 95-104
DOI 10.1091/mbc.e07-06-0565, PubMed 17959827

Torgersen ML, Wälchli S, Grimmer S, Skånland SS, Sandvig K (2007)
Protein kinase Cdelta is activated by Shiga toxin and regulates its transport
J Biol Chem, 282 (22), 16317-28
DOI 10.1074/jbc.M610886200, PubMed 17403690

Lauvrak SU, Wälchli S, Iversen TG, Slagsvold HH, Torgersen ML, Spilsberg B, Sandvig K (2005)
Shiga toxin regulates its entry in a Syk-dependent manner
Mol Biol Cell, 17 (3), 1096-109
DOI 10.1091/mbc.e05-08-0766, PubMed 16371508

Torgersen ML, Lauvrak SU, Sandvig K (2005)
The A-subunit of surface-bound Shiga toxin stimulates clathrin-dependent uptake of the toxin
FEBS J, 272 (16), 4103-13
DOI 10.1111/j.1742-4658.2005.04835.x, PubMed 16098193

Lauvrak SU, Torgersen ML, Sandvig K (2004)
Efficient endosome-to-Golgi transport of Shiga toxin is dependent on dynamin and clathrin
J Cell Sci, 117 (Pt 11), 2321-31
DOI 10.1242/jcs.01081, PubMed 15126632

Sandvig K, Spilsberg B, Lauvrak SU, Torgersen ML, Iversen TG, van Deurs B (2004)
Pathways followed by protein toxins into cells
Int J Med Microbiol, 293 (7-8), 483-90
DOI 10.1078/1438-4221-00294, PubMed 15149022

Birkeli KA, Llorente A, Torgersen ML, Keryer G, Taskén K, Sandvig K (2002)
Endosome-to-Golgi transport is regulated by protein kinase A type II alpha
J Biol Chem, 278 (3), 1991-7
DOI 10.1074/jbc.M209982200, PubMed 12419802

Sandvig K, Grimmer S, Lauvrak SU, Torgersen ML, Skretting G, van Deurs B, Iversen TG (2001)
Pathways followed by ricin and Shiga toxin into cells
Histochem Cell Biol, 117 (2), 131-41
DOI 10.1007/s00418-001-0346-2, PubMed 11935289

Torgersen ML, Skretting G, van Deurs B, Sandvig K (2001)
Internalization of cholera toxin by different endocytic mechanisms
J Cell Sci, 114 (Pt 20), 3737-47
DOI 10.1242/jcs.114.20.3737, PubMed 11707525

Sandvig K, Grimmer S, Iversen TG, Rodal K, Torgersen ML, Nicoziani P, van Deurs B (2000)
Ricin transport into cells: studies of endocytosis and intracellular transport
Int J Med Microbiol, 290 (4-5), 415-20
DOI 10.1016/S1438-4221(00)80055-7, PubMed 11111920

Hjertner O, Torgersen ML, Seidel C, Hjorth-Hansen H, Waage A, Børset M, Sundan A (1999)
Hepatocyte growth factor (HGF) induces interleukin-11 secretion from osteoblasts: a possible role for HGF in myeloma-associated osteolytic bone disease
Blood, 94 (11), 3883-8
PubMed 10572104

Skretting G, Torgersen ML, van Deurs B, Sandvig K (1999)
Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor
J Cell Sci, 112 ( Pt 22), 3899-909
DOI 10.1242/jcs.112.22.3899, PubMed 10547351

Review articles

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM et al. (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM et al. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652

Skotland T, Iversen TG, Torgersen ML, Sandvig K (2015)
Cell-penetrating peptides: possibilities and challenges for drug delivery in vitro and in vivo
Molecules, 20 (7), 13313-23
DOI 10.3390/molecules200713313, PubMed 26205056

Engedal N, Skotland T, Torgersen ML, Sandvig K (2011)
Shiga toxin and its use in targeted cancer therapy and imaging
Microb Biotechnol, 4 (1), 32-46
DOI 10.1111/j.1751-7915.2010.00180.x, PubMed 21255370

Sandvig K, Torgersen ML, Engedal N, Skotland T, Iversen TG (2010)
Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine
FEBS Lett, 584 (12), 2626-34
DOI 10.1016/j.febslet.2010.04.008, PubMed 20385131

Sandvig K, Torgersen ML, Raa HA, van Deurs B (2008)
Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity
Histochem Cell Biol, 129 (3), 267-76
DOI 10.1007/s00418-007-0376-5, PubMed 18193449

Hommelgaard AM, Roepstorff K, Vilhardt F, Torgersen ML, Sandvig K, van Deurs B (2005)
Caveolae: stable membrane domains with a potential for internalization
Traffic, 6 (9), 720-4
DOI 10.1111/j.1600-0854.2005.00314.x, PubMed 16101676