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Publications by Stein Sæbøe-Larssen

28 publications found

Original articles

Maggadottir SM, Dueland S, Mensali N, Hamre H, Andresen PA, Myhre MR, Juul HV, Bigalke I, Lundby M, Hønnåshagen TK, Sæbøe-Larssen S, Josefsen D, Hagtvedt T, Wälchli S, Kvalheim G, Inderberg EM (2024)
Transient TCR-based T-cell therapy in a patient with advanced treatment-resistant MSI-high colorectal cancer
Mol Ther (in press)
DOI 10.1016/j.ymthe.2024.04.009, PubMed 38582964

Maggadóttir SM, Kvalheim G, Wernhoff P, Sæbøe-Larssen S, Revheim ME, Josefsen D, Wälchli S, Helland Å, Inderberg EM (2022)
A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)
Front Oncol, 12, 1031232
DOI 10.3389/fonc.2022.1031232, PubMed 36439452

Tryggestad AMA, Axcrona K, Axcrona U, Bigalke I, Brennhovd B, Inderberg EM, Hønnåshagen TK, Skoge LJ, Solum G, Saebøe-Larssen S, Josefsen D, Olaussen RW, Aamdal S, Skotheim RI, Myklebust TÅ, Schendel DJ, Lilleby W, Dueland S, Kvalheim G (2021)
Long-term first-in-man Phase I/II study of an adjuvant dendritic cell vaccine in patients with high-risk prostate cancer after radical prostatectomy
Prostate, 82 (2), 245-253
DOI 10.1002/pros.24267, PubMed 34762317

Sæbøe-Larssen S, Sioud M (2020)
Improving Dendritic Cell Cancer Vaccine Potency Using RNA Interference
Methods Mol Biol, 2115, 249-258
DOI 10.1007/978-1-0716-0290-4_14, PubMed 32006405

Sioud M, Nyakas M, Sæbøe-Larssen S, Mobergslien A, Aamdal S, Kvalheim G (2016)
Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine
Case Rep Med, 2016, 9639585
DOI 10.1155/2016/9639585, PubMed 27504122

Sioud M, Mobergslien A, Sæbøe-Larssen S (2015)
Immunosuppressive factor blockade in dendritic cells via siRNAs results in objective clinical responses
Methods Mol Biol, 1218, 269-76
DOI 10.1007/978-1-4939-1538-5_16, PubMed 25319657

Vik-Mo EO, Nyakas M, Mikkelsen BV, Moe MC, Due-Tønnesen P, Suso EM, Sæbøe-Larssen S, Sandberg C, Brinchmann JE, Helseth E, Rasmussen AM, Lote K, Aamdal S, Gaudernack G, Kvalheim G, Langmoen IA (2013)
Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma
Cancer Immunol Immunother, 62 (9), 1499-509
DOI 10.1007/s00262-013-1453-3, PubMed 23817721

Sioud M, Skorstad G, Mobergslien A, Sæbøe-Larssen S (2013)
A novel peptide carrier for efficient targeting of antigens and nucleic acids to dendritic cells
FASEB J, 27 (8), 3272-83
DOI 10.1096/fj.12-224758, PubMed 23671272

Sioud M, Saebøe-Larssen S, Hetland TE, Kaern J, Mobergslien A, Kvalheim G (2013)
Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients
Int J Oncol, 43 (1), 280-8
DOI 10.3892/ijo.2013.1922, PubMed 23620105

Bøe SL, Jørgensen JA, Longva AS, Lavelle T, Sæbøe-Larssen S, Hovig E (2013)
Light-controlled modulation of gene expression using polyamidoamine formulations
Nucleic Acid Ther, 23 (2), 160-5
DOI 10.1089/nat.2012.0413, PubMed 23530684

Jarnjak-Jankovic S, Hammerstad H, Saebøe-Larssen S, Kvalheim G, Gaudernack G (2007)
A full scale comparative study of methods for generation of functional Dendritic cells for use as cancer vaccines
BMC Cancer, 7, 119
DOI 10.1186/1471-2407-7-119, PubMed 17608923

Jarnjak-Jankovic S, Saebøe-Larssen S, Kvalheim G, Gaudernack G (2007)
mRNA transfection of DC in the immature or mature state: comparable in vitro priming of Th and cytotoxic T lymphocytes against DC electroporated with tumor cell line-derived mRNA
Cytotherapy, 9 (6), 587-92
DOI 10.1080/14653240701466354, PubMed 17882723

Saebøe-Larssen S, Fossberg E, Gaudernack G (2006)
Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues
BMC Mol Biol, 7, 26
DOI 10.1186/1471-2199-7-26, PubMed 16939641

Jarnjak-Jankovic S, Pettersen RD, Saebøe-Larssen S, Wesenberg F, Olafsen MR, Gaudernack G (2005)
Preclinical evaluation of autologous dendritic cells transfected with mRNA or loaded with apoptotic cells for immunotherapy of high-risk neuroblastoma
Cancer Gene Ther, 12 (8), 699-707
DOI 10.1038/sj.cgt.7700820, PubMed 15846368

Kyte JA, Kvalheim G, Aamdal S, Saebøe-Larssen S, Gaudernack G (2005)
Preclinical full-scale evaluation of dendritic cells transfected with autologous tumor-mRNA for melanoma vaccination
Cancer Gene Ther, 12 (6), 579-91
DOI 10.1038/sj.cgt.7700837, PubMed 15818380

Jarnjak-Jankovic S, Pettersen RD, Saebøe-Larssen S, Wesenberg F, Gaudernack G (2005)
Evaluation of dendritic cells loaded with apoptotic cancer cells or expressing tumour mRNA as potential cancer vaccines against leukemia
BMC Cancer, 5, 20
DOI 10.1186/1471-2407-5-20, PubMed 15720715

Mu LJ, Lazarova P, Gaudernack G, Saeboe-Larssen S, Kvalheim G (2004)
Development of a clinical grade procedure for generation of mRNA transfected dendritic cells from purified frozen CD34(+) blood progenitor cells
Int J Immunopathol Pharmacol, 17 (3), 255-63
DOI 10.1177/039463200401700305, PubMed 15461859

Mu LJ, Gaudernack G, Saebøe-Larssen S, Hammerstad H, Tierens A, Kvalheim G (2003)
A protocol for generation of clinical grade mRNA-transfected monocyte-derived dendritic cells for cancer vaccines
Scand J Immunol, 58 (5), 578-86
DOI 10.1046/j.1365-3083.2003.01333.x, PubMed 14629630

Gjertsen MK, Saeterdal I, Saebøe-Larssen S, Gaudernack G (2002)
HLA-A3 restricted mutant ras specific cytotoxic T-lymphocytes induced by vaccination with T-helper epitopes
J Mol Med (Berl), 81 (1), 43-50
DOI 10.1007/s00109-002-0390-y, PubMed 12545248

Saebøe-Larssen S, Fossberg E, Gaudernack G (2002)
mRNA-based electrotransfection of human dendritic cells and induction of cytotoxic T lymphocyte responses against the telomerase catalytic subunit (hTERT)
J Immunol Methods, 259 (1-2), 191-203
DOI 10.1016/s0022-1759(01)00506-3, PubMed 11730854

Lundqvist A, Noffz G, Pavlenko M, Saebøe-Larssen S, Fong T, Maitland N, Pisa P (2002)
Nonviral and viral gene transfer into different subsets of human dendritic cells yield comparable efficiency of transfection
J Immunother, 25 (6), 445-54
DOI 10.1097/00002371-200211000-00001, PubMed 12439342

Saebøe-Larssen S, Lyamouri M, Merriam J, Oksvold MP, Lambertsson A (1998)
Ribosomal protein insufficiency and the minute syndrome in Drosophila: a dose-response relationship
Genetics, 148 (3), 1215-24
DOI 10.1093/genetics/148.3.1215, PubMed 9539436

Saebøe-Larssen S, Urbanczyk Mohebi B, Lambertsson A (1997)
The Drosophila ribosomal protein L14-encoding gene, identified by a novel Minute mutation in a dense cluster of previously undescribed genes in cytogenetic region 66D
Mol Gen Genet, 255 (2), 141-51
DOI 10.1007/s004380050482, PubMed 9236770

Saebøe-Larssen S, Lambertsson A (1996)
A novel Drosophila Minute locus encodes ribosomal protein S13
Genetics, 143 (2), 877-85
DOI 10.1093/genetics/143.2.877, PubMed 8725235

Stacy RA, Espelund M, Saebøe-Larssen S, Hollung K, Helliesen E, Jakobsen KS (1995)
Evolution of the Group 1 late embryogenesis abundant (Lea) genes: analysis of the Lea B19 gene family in barley
Plant Mol Biol, 28 (6), 1039-54
DOI 10.1007/BF00032665, PubMed 7548822

Andersson S, Saebøe-Larssen S, Lambertsson A, Merriam J, Jacobs-Lorena M (1994)
A Drosophila third chromosome Minute locus encodes a ribosomal protein
Genetics, 137 (2), 513-20
DOI 10.1093/genetics/137.2.513, PubMed 8070662

Espelund M, Saebøe-Larssen S, Hughes DW, Galau GA, Larsen F, Jakobsen KS (1992)
Late embryogenesis-abundant genes encoding proteins with different numbers of hydrophilic repeats are regulated differentially by abscisic acid and osmotic stress
Plant J, 2 (2), 241-52
PubMed 1302052

Review articles

Bøe S, Saebøe-Larssen S, Hovig E (2010)
Light-induced gene expression using messenger RNA molecules
Oligonucleotides, 20 (1), 1-6
DOI 10.1089/oli.2009.0209, PubMed 20038251