Publications by Gisle Langslet
68 publications found
Original articles
Empagliflozin is associated with lower cardiovascular risk compared with dipeptidyl peptidase-4 inhibitors in adults with and without cardiovascular disease: EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) study results from Europe and Asia
Cardiovasc Diabetol, 22 (1), 233
DOI 10.1186/s12933-023-01963-9, PubMed 37653496
Young women with familial hypercholesterolemia have higher LDL-cholesterol burden than men: Novel data using repeated measurements during 12-years follow-up
Atheroscler Plus, 51, 28-34
DOI 10.1016/j.athplu.2023.01.001, PubMed 36911286
Empagliflozin cardiovascular and renal effectiveness and safety compared to dipeptidyl peptidase-4 inhibitors across 11 countries in Europe and Asia: Results from the EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) study
Diabetes Metab, 49 (2), 101418
DOI 10.1016/j.diabet.2022.101418, PubMed 36608816
Thirty percent of children and young adults with familial hypercholesterolemia treated with statins have adherence issues
Am J Prev Cardiol, 6, 100180
DOI 10.1016/j.ajpc.2021.100180, PubMed 34327501
Risk of Recurrent Coronary Events in Patients With Familial Hypercholesterolemia; A 10-Years Prospective Study
Front Pharmacol, 11, 560958
DOI 10.3389/fphar.2020.560958, PubMed 33737874
Long term follow-up of children with familial hypercholesterolemia and relatively normal LDL-cholesterol at diagnosis
J Clin Lipidol, 15 (2), 375-378
DOI 10.1016/j.jacl.2021.01.007, PubMed 33608220
Subjects with familial hypercholesterolemia have lower aortic valve area and higher levels of inflammatory biomarkers
J Clin Lipidol, 15 (1), 134-141
DOI 10.1016/j.jacl.2020.12.006, PubMed 33358307
Genetic testing is essential for initiating statin therapy in children with familial hypercholesterolemia: Examples from Scandinavia
Atherosclerosis, 316, 48-52
DOI 10.1016/j.atherosclerosis.2020.11.027, PubMed 33302044
Regional Variations in Alirocumab Dosing Patterns in Patients with Heterozygous Familial Hypercholesterolemia During an Open-Label Extension Study
Cardiovasc Drugs Ther, 34 (4), 515-523
DOI 10.1007/s10557-020-06984-0, PubMed 32363493
Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME®
Diab Vasc Dis Res, 17 (6), 1479164120975256
DOI 10.1177/1479164120975256, PubMed 33307785
Efficacy and Safety of Alirocumab 300 mg Every 4 Weeks in Individuals With Type 2 Diabetes on Maximally Tolerated Statin
J Clin Endocrinol Metab, 104 (11), 5253-5262
DOI 10.1210/jc.2018-02703, PubMed 31166599
Long-Term Efficacy and Safety of Evolocumab in Patients With Hypercholesterolemia
J Am Coll Cardiol, 74 (17), 2132-2146
DOI 10.1016/j.jacc.2019.08.1024, PubMed 31648705
LDL-cholesterol goal achievement, cardiovascular disease, and attributed risk of Lp(a) in a large cohort of predominantly genetically verified familial hypercholesterolemia
J Clin Lipidol, 13 (2), 279-286
DOI 10.1016/j.jacl.2019.01.010, PubMed 30910667
Familial hypercholesterolemia and young patients' thoughts on own condition and treatment
Patient Educ Couns, 102 (5), 1005-1012
DOI 10.1016/j.pec.2018.12.025, PubMed 30606641
Individualized low-density lipoprotein cholesterol reduction with alirocumab titration strategy in heterozygous familial hypercholesterolemia: Results from an open-label extension of the ODYSSEY LONG TERM trial
J Clin Lipidol, 13 (1), 138-147
DOI 10.1016/j.jacl.2018.11.007, PubMed 30591415
Long-term safety and efficacy of alirocumab in patients with heterozygous familial hypercholesterolemia: An open-label extension of the ODYSSEY program
Atherosclerosis, 278, 307-314
DOI 10.1016/j.atherosclerosis.2018.08.036, PubMed 30293878
Efficacy and Safety of Alirocumab in High-Risk Patients With Clinical Atherosclerotic Cardiovascular Disease and/or Heterozygous Familial Hypercholesterolemia (from 5 Placebo-Controlled ODYSSEY Trials)
Am J Cardiol, 121 (8), 940-948
DOI 10.1016/j.amjcard.2017.12.040, PubMed 29472008
Efficacy, safety, and tolerability of evolocumab in pediatric patients with heterozygous familial hypercholesterolemia: Rationale and design of the HAUSER-RCT study
J Clin Lipidol, 12 (5), 1199-1207
DOI 10.1016/j.jacl.2018.05.007, PubMed 30318065
Sex differences in cholesterol levels from birth to 19 years of age may lead to increased cholesterol burden in females with FH
J Clin Lipidol, 12 (3), 748-755.e2
DOI 10.1016/j.jacl.2018.02.021, PubMed 29609857
Alirocumab dosing patterns during 40 months of open-label treatment in patients with heterozygous familial hypercholesterolemia
J Clin Lipidol, 12 (6), 1463-1470
DOI 10.1016/j.jacl.2018.08.011, PubMed 30287210
Alirocumab efficacy in patients with double heterozygous, compound heterozygous, or homozygous familial hypercholesterolemia
J Clin Lipidol, 12 (2), 390-396.e8
DOI 10.1016/j.jacl.2017.12.008, PubMed 29396260
Treatment goal attainment in children with familial hypercholesterolemia: A cohort study of 302 children in Norway
J Clin Lipidol, 12 (2), 375-382
DOI 10.1016/j.jacl.2017.11.009, PubMed 29310990
Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label)
Circulation, 136 (4), 359-366
DOI 10.1161/CIRCULATIONAHA.116.025158, PubMed 28592434
Long-term Low-Density Lipoprotein Cholesterol-Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia: Results Up to 4 Years From the Open-Label OSLER-1 Extension Study
JAMA Cardiol, 2 (6), 598-607
DOI 10.1001/jamacardio.2017.0747, PubMed 28291870
Efficacy of alirocumab in 1191 patients with a wide spectrum of mutations in genes causative for familial hypercholesterolemia
J Clin Lipidol, 11 (6), 1338-1346.e7
DOI 10.1016/j.jacl.2017.08.016, PubMed 28964736
Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody alirocumab vs placebo in patients with heterozygous familial hypercholesterolemia
J Clin Lipidol, 11 (1), 195-203.e4
DOI 10.1016/j.jacl.2016.12.004, PubMed 28391886
A phase III randomized trial evaluating alirocumab 300 mg every 4 weeks as monotherapy or add-on to statin: ODYSSEY CHOICE I
Atherosclerosis, 254, 254-262
DOI 10.1016/j.atherosclerosis.2016.08.043, PubMed 27639753
Simultaneous Reduction in Both HbA1c and Body Weight with Canagliflozin Versus Glimepiride in Patients with Type 2 Diabetes on Metformin
Diabetes Ther, 7 (2), 269-78
DOI 10.1007/s13300-016-0163-1, PubMed 26984361
A 3-year study of atorvastatin in children and adolescents with heterozygous familial hypercholesterolemia
J Clin Lipidol, 10 (5), 1153-1162.e3
DOI 10.1016/j.jacl.2016.05.010, PubMed 27678432
ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
Eur Heart J, 36 (43), 2996-3003
DOI 10.1093/eurheartj/ehv370, PubMed 26330422
Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk
J Pediatr, 167 (2), 338-43.e5
DOI 10.1016/j.jpeds.2015.05.006, PubMed 26059337
Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 diabetes: a randomized, controlled study (GENERATION)
Diabetes Obes Metab, 17 (7), 630-8
DOI 10.1111/dom.12461, PubMed 25761977
Evolocumab (AMG 145) for primary hypercholesterolemia
Expert Rev Cardiovasc Ther, 13 (5), 477-88
DOI 10.1586/14779072.2015.1030395, PubMed 25824308
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
N Engl J Med, 372 (16), 1489-99
DOI 10.1056/NEJMoa1501031, PubMed 25773378
Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study
Lancet, 385 (9983), 2153-61
DOI 10.1016/S0140-6736(14)62115-2, PubMed 25743173
Long-term follow-up of young adults with familial hypercholesterolemia after participation in clinical trials during childhood
J Clin Lipidol, 9 (6), 778-785
DOI 10.1016/j.jacl.2015.08.008, PubMed 26687698
Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study
J Clin Lipidol, 9 (6), 741-750
DOI 10.1016/j.jacl.2015.07.011, PubMed 26687694
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial
Lancet, 385 (9965), 331-40
DOI 10.1016/S0140-6736(14)61399-4, PubMed 25282519
Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study
Diabetes Care, 38 (3), 355-64
DOI 10.2337/dc13-2762, PubMed 25205142
Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach
Eur J Hum Genet, 23 (3), 381-7
DOI 10.1038/ejhg.2014.101, PubMed 24916650
Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies
Cardiovasc Drugs Ther, 28 (3), 281-9
DOI 10.1007/s10557-014-6523-z, PubMed 24842558
Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study
Lancet Diabetes Endocrinol, 2 (6), 455-63
DOI 10.1016/S2213-8587(14)70006-3, PubMed 24731671
Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials
J Am Coll Cardiol, 63 (13), 1278-1288
DOI 10.1016/j.jacc.2014.01.006, PubMed 24509273
Subjects with familial hypercholesterolemia are characterized by an inflammatory phenotype despite long-term intensive cholesterol lowering treatment
Atherosclerosis, 233 (2), 561-567
DOI 10.1016/j.atherosclerosis.2014.01.022, PubMed 24530965
Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial
Circulation, 129 (2), 234-43
DOI 10.1161/CIRCULATIONAHA.113.007012, PubMed 24255061
No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy
Scand Cardiovasc J, 47 (2), 80-7
DOI 10.3109/14017431.2012.756119, PubMed 23301875
Design and baseline data of a pediatric study with rosuvastatin in familial hypercholesterolemia
J Clin Lipidol, 7 (5), 408-13
DOI 10.1016/j.jacl.2013.06.010, PubMed 24079281
Apheresis in homozygous familial hypercholesterolemia: the results of a follow-up of all Norwegian patients with homozygous familial hypercholesterolemia
J Clin Lipidol, 6 (4), 331-9
DOI 10.1016/j.jacl.2012.03.004, PubMed 22836070
Lipoprotein(a) levels in coronary heart disease-susceptible and -resistant patients with familial hypercholesterolemia
Atherosclerosis, 216 (2), 426-32
DOI 10.1016/j.atherosclerosis.2011.02.007, PubMed 21376325
[Clinical trials--viewpoints from participants]
Tidsskr Nor Laegeforen, 130 (16), 1606-8
DOI 10.4045/tidsskr.09.0030, PubMed 20805857
HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study
Scand Cardiovasc J, 44 (4), 197-200
DOI 10.3109/14017431003624123, PubMed 20636227
Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia
J Am Coll Cardiol, 55 (11), 1121-6
DOI 10.1016/j.jacc.2009.10.042, PubMed 20223367
Review articles
High levels of lipoprotein(a) - assessment and treatment
Tidsskr Nor Laegeforen, 142 (1)
DOI 10.4045/tidsskr.21.0800, PubMed 36655975
Do we need new lipid-lowering agents in the era of PCSK9 inhibitors? Recent advances
Kardiol Pol, 80 (7-8), 741-749
DOI 10.33963/KP.a2022.0117, PubMed 35521719
The heart failure burden of type 2 diabetes mellitus-a review of pathophysiology and interventions
Heart Fail Rev, 23 (3), 303-323
DOI 10.1007/s10741-018-9685-0, PubMed 29516230
Screening methods in the diagnosis and assessment of children and adolescents with familial hypercholesterolemia
Expert Rev Cardiovasc Ther, 11 (8), 1061-6
DOI 10.1586/14779072.2013.814851, PubMed 23984929
[Can cardiovascular events be prevented by raising HDL cholesterol?]
Tidsskr Nor Laegeforen, 128 (13), 1519-23
PubMed 18587459
Other articles
Is prediabetes a cardiovascular risk factor in patients with coronary artery disease?
Eur J Prev Cardiol, 30 (14), 1416-1417
DOI 10.1093/eurjpc/zwad097, PubMed 37036914
Dairy fat and cardiovascular disease: good or bad? A lipidologist's view
Eur J Prev Cardiol, 30 (3), 217-218
DOI 10.1093/eurjpc/zwac244, PubMed 36315006
[Correction: High levels of lipoprotein(a) – assessment and treatment]
Tidsskr Nor Laegeforen, 143 (2)
DOI 10.4045/tidsskr.23.0023, PubMed 36718898
Treatment goals in familial hypercholesterolaemia-time to consider low-density lipoprotein-cholesterol burden
Eur J Prev Cardiol, 29 (17), 2278-2280
DOI 10.1093/eurjpc/zwab228, PubMed 34935933
Resmetirom (MGL-3196) in Patients With Heterozygous Familial Hypercholesterolemia
J Am Coll Cardiol, 79 (12), 1220-1222
DOI 10.1016/j.jacc.2022.01.023, PubMed 35331419
Corrigendum to "Efficacy of alirocumab in 1191 patients with a wide spectrum of mutations in genes causative for familial hypercholesterolemia" J Clin Lipidol 11 (2017) 1338-1346
J Clin Lipidol, 14 (5), 742
DOI 10.1016/j.jacl.2020.09.010, PubMed 33138962
Author's response to: letter to the editor
Heart Fail Rev, 23 (5), 819
DOI 10.1007/s10741-018-9728-6, PubMed 30043131
Response to the editor
Heart Fail Rev (in press)
DOI 10.1007/s10741-018-9723-y, PubMed 29968222
Response by Kusters et al to Letter Regarding Article, "Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label)"
Circulation, 137 (6), 641-642
DOI 10.1161/CIRCULATIONAHA.117.031676, PubMed 29431667
Some children with a familial hypercholesterolemia mutation may exhibit persistent low LDL levels
J Clin Lipidol, 12 (5), 1327-1328
DOI 10.1016/j.jacl.2018.06.012, PubMed 30033003
Replacing statins with PCSK9-inhibitors and delaying treatment until 18 years of age in patients with familial hypercholesterolaemia is not a good idea
Eur Heart J, 37 (17), 1357-9
DOI 10.1093/eurheartj/ehw098, PubMed 27026748