Publication list - Publika - Scientific publications from Oslo University Hospital

Publications by Lars Heggelund

55 publications found

Original articles

Markussen DL, Kommedal Ø, Knoop ST, Ebbesen MH, Bjørneklett RO, Ritz C, Heggelund L, Ulvestad E, Serigstad S, Grewal HMS (2024)
Microbial aetiology of community-acquired pneumonia in hospitalized adults: a prospective study utilising comprehensive molecular testing
Int J Infect Dis, 107019 (in press)
DOI 10.1016/j.ijid.2024.107019, PubMed 38582145

Barratt-Due A, Pettersen K, Børresdatter-Dahl T, Holter JC, Grønli RH, Dyrhol-Riise AM, Lerum TV, Holten AR, Tonby K, Trøseid M, Skjønsberg OH, Granerud BK, Heggelund L, Kildal AB, Schjalm C, Aaløkken TM, Aukrust P, Ueland T, Mollnes TE, Halvorsen B, NOR‐Solidarity study groupThe Norwegian SARS‐CoV‐2 study group (2024)
Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients
J Intern Med (in press)
DOI 10.1111/joim.13783, PubMed 38539241

Markussen DL, Serigstad S, Ritz C, Knoop ST, Ebbesen MH, Faurholt-Jepsen D, Heggelund L, van Werkhoven CH, Clark TW, Bjørneklett RO, Kommedal Ø, Ulvestad E, Grewal HMS (2024)
Diagnostic Stewardship in Community-Acquired Pneumonia With Syndromic Molecular Testing: A Randomized Clinical Trial
JAMA Netw Open, 7 (3), e240830
DOI 10.1001/jamanetworkopen.2024.0830, PubMed 38446481

Murphy SL, Halvorsen B, Holter JC, Huse C, Tveita A, Trøseid M, Hoel H, Kildal AB, Holten AR, Lerum TV, Skjønsberg OH, Michelsen AE, Aaløkken TM, NOR-SOLIDARITY Consortium, The Norwegian SARS-CoV-2 study group investigators, Tonby K, Lind A, Dudman S, Granerud BK, Heggelund L, Bøe S, Dyrholt-Riise AM, Aukrust P, Barratt-Due A, Ueland T, Dahl TB (2023)
Circulating markers of extracellular matrix remodelling in severe COVID-19 patients
J Intern Med, 294 (6), 784-797
DOI 10.1111/joim.13725, PubMed 37718572

Grønseth S, Rogne T, Heggelund L, Åsvold BO, Afset JE, Damås JK (2023)
Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort
Int J Infect Dis, 134, 177-186
DOI 10.1016/j.ijid.2023.06.013, PubMed 37339716

Floeystad HK, Holter JC, Husebye E, Siljan WW, Berild D, Holm AM, Heggelund L (2023)
Nausea Predicts Bacteremia in Immunocompetent Patients with Pneumococcal Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort
J Clin Med, 12 (12)
DOI 10.3390/jcm12123924, PubMed 37373619

Abdelhak A, Barba L, Romoli M, Benkert P, Conversi F, D'Anna L, Masvekar RR, Bielekova B, Prudencio M, Petrucelli L, Meschia JF, Erben Y, Furlan R, De Lorenzo R, Mandelli A, Sutter R, Hert L, Epple V, Marastoni D, Sellner J, Steinacker P, Aamodt AH, Heggelund L, Dyrhol-Riise AM, Virhammar J et al. (2023)
Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis
J Neurol, 270 (7), 3315-3328
DOI 10.1007/s00415-023-11768-1, PubMed 37184659

Oppen K, Brede C, Skadberg Ø, Steinsvik T, Holter JC, Michelsen AE, Heggelund L (2023)
Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS
Ann Clin Biochem, 60 (5), 298-305
DOI 10.1177/00045632231159529, PubMed 36759502

Trøseid M, Holter JC, Holm K, Vestad B, Sazonova T, Granerud BK, Dyrhol-Riise AM, Holten AR, Tonby K, Kildal AB, Heggelund L, Tveita A, Bøe S, Müller KE, Jenum S, Hov JR, Ueland T, Norwegian SARS-CoV-2 study group (2023)
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
Crit Care, 27 (1), 69
DOI 10.1186/s13054-023-04356-2, PubMed 36814280

Trøseid M, Arribas JR, Assoumou L, Holten AR, Poissy J, Terzić V, Mazzaferri F, Baño JR, Eustace J, Hites M, Joannidis M, Paiva JA, Reuter J, Püntmann I, Patrick-Brown TDJH, Westerheim E, Nezvalova-Henriksen K, Beniguel L, Dahl TB, Bouscambert M, Halanova M, Péterfi Z, Tsiodras S, Rezek M, Briel M et al. (2023)
Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial
Crit Care, 27 (1), 9
DOI 10.1186/s13054-022-04205-8, PubMed 36627655

Tveita A, Murphy SL, Holter JC, Kildal AB, Michelsen AE, Lerum TV, Kaarbø M, Heggelund L, Holten AR, Finbråten AK, Müller KE, Mathiessen A, Bøe S, Fevang B, Granerud BK, Tonby K, Lind A, Dudman SG, Henriksen KN, Müller F, Skjønsberg OH, Trøseid M, Barratt-Due A, Dyrhol-Riise AM, Aukrust P et al. (2022)
High Circulating Levels of the Homeostatic Chemokines CCL19 and CCL21 Predict Mortality and Disease Severity in COVID-19
J Infect Dis, 226 (12), 2150-2160
DOI 10.1093/infdis/jiac313, PubMed 35876699

Olsen MB, Huse C, de Sousa MML, Murphy SL, Sarno A, Obermann TS, Yang K, Holter JC, Jørgensen MJ, Christensen EE, Wang W, Ji P, Heggelund L, Hoel H, Dyrhol-Riise AM, Gregersen I, Aukrust P, Bjørås M, Halvorsen B, Dahl TB (2022)
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients
J Inflamm Res, 15, 6629-6644
DOI 10.2147/JIR.S379331, PubMed 36514358

Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Blandino Ortiz A, de Salazar A, Garrido Chercoles A, Palom A, Ruiz A, Garcia-Fernandez AE, Blanco-Grau A, Mantovani A, Zanella A et al. (2022)
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Hum Mol Genet, 31 (23), 3945-3966
DOI 10.1093/hmg/ddac158, PubMed 35848942

Waagsbø B, Tranung M, Damås JK, Heggelund L (2022)
Antimicrobial therapy of community-acquired pneumonia during stewardship efforts and a coronavirus pandemic: an observational study
BMC Pulm Med, 22 (1), 379
DOI 10.1186/s12890-022-02178-6, PubMed 36242006

Serigstad S, Markussen DL, Ritz C, Ebbesen MH, Knoop ST, Kommedal Ø, Heggelund L, Ulvestad E, Bjørneklett RO, Grewal HMS, CAPNOR study group (2022)
The changing spectrum of microbial aetiology of respiratory tract infections in hospitalized patients before and during the COVID-19 pandemic
BMC Infect Dis, 22 (1), 763
DOI 10.1186/s12879-022-07732-5, PubMed 36180842

Trøseid M, Dahl TB, Holter JC, Kildal AB, Murphy SL, Yang K, Quiles-Jiménez A, Heggelund L, Müller KE, Tveita A, Michelsen AE, Bøe S, Holten AR, Hoel H, Mathiessen A, Aaløkken TM, Fevang B, Granerud BK, Tonby K, Henriksen KN, Lerum TV, Müller F, Skjønsberg OH, Barratt-Due A, Dyrhol-Riise AM et al. (2022)
Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies
J Intern Med, 292 (5), 816-828
DOI 10.1111/joim.13549, PubMed 35982589

Serigstad S, Ritz C, Faurholt-Jepsen D, Markussen D, Ebbesen MH, Kommedal Ø, Bjørneklett RO, Heggelund L, Clark TW, van Werkhoven CH, Knoop ST, Ulvestad E, Grewal HMS, CAPNOR study group (2022)
Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR)
Trials, 23 (1), 622
DOI 10.1186/s13063-022-06467-7, PubMed 35915452

Waagsbø B, Stuve N, Afset JE, Klepstad P, Mo S, Heggelund L, Damås JK (2022)
High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting
Infect Dis (Lond), 54 (10), 738-747
DOI 10.1080/23744235.2022.2083672, PubMed 35708021

Siljan WW, Sivakumaran D, Ritz C, Jenum S, Ottenhoff TH, Ulvestad E, Holter JC, Heggelund L, Grewal HM (2022)
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools
Biomark Insights, 17, 11772719221099130
DOI 10.1177/11772719221099130, PubMed 35693251

Søvik S, Barrat-Due A, Kåsine T, Olasveengen T, Strand MW, Tveita AA, Berdal JE, Lehre MA, Lorentsen T, Heggelund L, Stenstad T, Ringstad J, Müller F, Aukrust P, Holter JC, Nordøy I (2022)
Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation
J Infect, 85 (1), 57-63
DOI 10.1016/j.jinf.2022.05.015, PubMed 35605805

Waagsbø B, Buset EM, Longva JÅ, Bjerke M, Bakkene B, Ertesvåg AS, Holmen H, Nikodojevic M, Tran TT, Christensen A, Nilsen E, Damås JK, Heggelund L (2022)
Diagnostic stewardship aiming at expectorated or induced sputum promotes microbial diagnosis in community-acquired pneumonia
BMC Infect Dis, 22 (1), 203
DOI 10.1186/s12879-022-07199-4, PubMed 35236305

Oppen K, Ueland T, Michelsen AE, Aukrust P, Steinsvik T, Skadberg Ø, Brede C, Siljan WW, Husebye E, Holter JC, Heggelund L (2022)
Hepcidin predicts 5-year mortality after community-acquired pneumonia
Infect Dis (Lond), 54 (6), 403-409
DOI 10.1080/23744235.2021.2022194, PubMed 35057702

Barratt-Due A, Olsen IC, Nezvalova-Henriksen K, Kåsine T, Lund-Johansen F, Hoel H, Holten AR, Tveita A, Mathiessen A, Haugli M, Eiken R, Kildal AB, Berg Å, Johannessen A, Heggelund L, Dahl TB, Skåra KH, Mielnik P, Le LAK, Thoresen L, Ernst G, Hoff DAL, Skudal H, Kittang BR, Olsen RB et al. (2021)
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial
Ann Intern Med, 174 (9), 1261-1269
DOI 10.7326/M21-0653, PubMed 34251903

Aamodt AH, Høgestøl EA, Popperud TH, Holter JC, Dyrhol-Riise AM, Tonby K, Stiksrud B, Quist-Paulsen E, Berge T, Barratt-Due A, Aukrust P, Heggelund L, Blennow K, Zetterberg H, Harbo HF (2021)
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19
J Neurol, 268 (10), 3574-3583
DOI 10.1007/s00415-021-10517-6, PubMed 33743046

Oppen K, Ueland T, Siljan WW, Skadberg Ø, Brede C, Lauritzen T, Aukrust P, Steinsvik T, Husebye E, Michelsen AE, Holter JC, Heggelund L (2021)
Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia
Open Forum Infect Dis, 8 (4), ofab082
DOI 10.1093/ofid/ofab082, PubMed 33880390

Jøntvedt Jørgensen M, Holter JC, Christensen EE, Schjalm C, Tonby K, Pischke SE, Jenum S, Skeie LG, Nur S, Lind A, Opsand H, Enersen TB, Grøndahl R, Hermann A, Dudman S, Muller F, Ueland T, Mollnes TE, Aukrust P, Heggelund L, Holten AR, Dyrhol-Riise AM (2020)
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843

Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jørgensen MJ, Barratt-Due A, Skeie LG, Nordøy I, Aanensen Fraz MS, Quist-Paulsen E E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Müller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM et al. (2020)
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538

Siljan WW, Holter JC, Michelsen AE, Nymo SH, Lauritzen T, Oppen K, Husebye E, Ueland T, Mollnes TE, Aukrust P, Heggelund L (2019)
Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study
ERJ Open Res, 5 (1)
DOI 10.1183/23120541.00014-2019, PubMed 30863773

Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Skattum L, Bosnes V, Garred P, Frøland SS, Mollnes TE, Aukrust P, Heggelund L (2018)
Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia
Open Forum Infect Dis, 5 (2), ofy002
DOI 10.1093/ofid/ofy002, PubMed 29410975

Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Aukrust P, Mollnes TE, Heggelund L (2017)
Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia
Eur J Clin Invest, 48 (1)
DOI 10.1111/eci.12865, PubMed 29171871

Dalgard O, Weiland O, Noraberg G, Karlsen L, Heggelund L, Färkkilâ M, Balslev U, Belard E, Øvrehus A, Skalshøi Kjær M, Krarup H, Thorup Røge B, Hallager S, Madsen LG, Lund Laursen A, Lagging M, Weis N (2017)
Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections-A Scandinavian real-life study
PLoS One, 12 (7), e0179764
DOI 10.1371/journal.pone.0179764, PubMed 28704381

Holter JC, Ueland T, Norseth J, Brunborg C, Frøland SS, Husebye E, Aukrust P, Heggelund L (2016)
Vitamin D Status and Long-Term Mortality in Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort
PLoS One, 11 (7), e0158536
DOI 10.1371/journal.pone.0158536, PubMed 27367810

Holter JC, Ueland T, Jenum PA, Müller F, Brunborg C, Frøland SS, Aukrust P, Husebye E, Heggelund L (2016)
Risk Factors for Long-Term Mortality after Hospitalization for Community-Acquired Pneumonia: A 5-Year Prospective Follow-Up Study
PLoS One, 11 (2), e0148741
DOI 10.1371/journal.pone.0148741, PubMed 26849359

Midgard H, Bjøro B, Mæland A, Konopski Z, Kileng H, Damås JK, Paulsen J, Heggelund L, Sandvei PK, Ringstad JO, Karlsen LN, Stene-Johansen K, Pettersson JH, Dorenberg DH, Dalgard O (2016)
Hepatitis C reinfection after sustained virological response
J Hepatol, 64 (5), 1020-1026
DOI 10.1016/j.jhep.2016.01.001, PubMed 26780289

Heggelund L, Gaustad P, Håvelsrud OE, Blom J, Borgen L, Sundset A, Sørum H, Frøland SS (2015)
Corynebacterium pseudotuberculosis Pneumonia in a Veterinary Student Infected During Laboratory Work
Open Forum Infect Dis, 2 (2), ofv053
DOI 10.1093/ofid/ofv053, PubMed 26380345

Holter JC, Müller F, Bjørang O, Samdal HH, Marthinsen JB, Jenum PA, Ueland T, Frøland SS, Aukrust P, Husebye E, Heggelund L (2015)
Etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in Norway
BMC Infect Dis, 15, 64
DOI 10.1186/s12879-015-0803-5, PubMed 25887603

Dale E, Heggelund L, Leegard TM, Samdal HH, Edvardsen T, Gjertsen E (2010)
[Dramatic case report caused by a rare bacteria]
Tidsskr Nor Laegeforen, 130 (2), 149-51
DOI 10.4045/tidsskr.08.0715, PubMed 20125205

Damås JK, Landrø L, Fevang B, Heggelund L, Frøland SS, Aukrust P (2009)
Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy
AIDS, 23 (1), 135-8
DOI 10.1097/QAD.0b013e32831cf595, PubMed 19050397

Holven KB, Damås JK, Yndestad A, Waehre T, Ueland T, Halvorsen B, Heggelund L, Sandberg WJ, Semb AG, Frøland SS, Ose L, Nenseter MS, Aukrust P (2005)
Chemokines in children with heterozygous familiar hypercholesterolemia: selective upregulation of RANTES
Arterioscler Thromb Vasc Biol, 26 (1), 200-5
DOI 10.1161/01.ATV.0000193619.67288.ed, PubMed 16254204

Fiane AE, Ueland T, Simonsen S, Scott H, Endresen K, Gullestad L, Geiran OR, Haraldsen G, Heggelund L, Andreassen AK, Wergeland R, Frøland S, Aukrust P, Mollnes TE (2005)
Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation
Eur Heart J, 26 (16), 1660-5
DOI 10.1093/eurheartj/ehi198, PubMed 15821010

Heggelund L, Flo T, Berg K, Lien E, Mollnes TE, Ueland T, Aukrust P, Espevik T, Frøland SS (2004)
Soluble toll-like receptor 2 in HIV infection: association with disease progression
AIDS, 18 (18), 2437-9
PubMed 15622324

Heggelund L, Müller F, Lien E, Yndestad A, Ueland T, Kristiansen KI, Espevik T, Aukrust P, Frøland SS (2004)
Increased expression of toll-like receptor 2 on monocytes in HIV infection: possible roles in inflammation and viral replication
Clin Infect Dis, 39 (2), 264-9
DOI 10.1086/421780, PubMed 15307037

Fiane AE, Videm V, Lingaas PS, Heggelund L, Nielsen EW, Geiran OR, Fung M, Mollnes TE (2003)
Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair
Circulation, 108 (7), 849-56
DOI 10.1161/01.CIR.0000084550.16565.01, PubMed 12900342

Heggelund L, Mollnes TE, Ueland T, Christophersen B, Aukrust P, Frøland SS (2003)
Mannose-binding lectin in HIV infection: relation to disease progression and highly active antiretroviral therapy
J Acquir Immune Defic Syndr, 32 (4), 354-61
DOI 10.1097/00126334-200304010-00002, PubMed 12640191