Publications by Inger Helene Madshus
68 publications found
Original articles
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3
Carcinogenesis, 34 (9), 2031-8
DOI 10.1093/carcin/bgt173, PubMed 23698633
Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes
Exp Cell Res, 319 (3), 32-45
DOI 10.1016/j.yexcr.2012.10.010, PubMed 23127513
Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis
Exp Cell Res, 318 (20), 2578-91
DOI 10.1016/j.yexcr.2012.09.001, PubMed 22975728
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab
Pharmaceuticals (Basel), 5 (7), 674-89
DOI 10.3390/ph5070674, PubMed 24281706
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner
Carcinogenesis, 33 (5), 1031-9
DOI 10.1093/carcin/bgs128, PubMed 22436610
Differential roles of Grb2 and AP-2 in p38 MAPK- and EGF-induced EGFR internalization
Traffic, 13 (4), 576-85
DOI 10.1111/j.1600-0854.2011.01322.x, PubMed 22192528
Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations
J Immunother, 34 (7), 550-5
DOI 10.1097/CJI.0b013e31822a5ca6, PubMed 21760527
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor
Exp Cell Res, 317 (13), 1804-16
DOI 10.1016/j.yexcr.2011.05.016, PubMed 21635887
A chimeric pre-ubiquitinated EGF receptor is constitutively endocytosed in a clathrin-dependent, but kinase-independent manner
Traffic, 12 (4), 507-20
DOI 10.1111/j.1600-0854.2011.01162.x, PubMed 21226813
Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking
J Cell Sci, 122 (Pt 19), 3433-9
DOI 10.1242/jcs.050260, PubMed 19759283
Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization
Mol Cancer Ther, 8 (7), 1885-92
DOI 10.1158/1535-7163.MCT-09-0291, PubMed 19584234
Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2
Mol Cancer Res, 7 (2), 275-84
DOI 10.1158/1541-7786.MCR-07-2183, PubMed 19208749
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits
Traffic, 10 (2), 235-45
DOI 10.1111/j.1600-0854.2008.00858.x, PubMed 19054389
Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent
Mol Cancer Res, 6 (3), 491-500
DOI 10.1158/1541-7786.MCR-07-0191, PubMed 18337455
Dysregulation of Ack1 inhibits down-regulation of the EGF receptor
Exp Cell Res, 314 (6), 1292-300
DOI 10.1016/j.yexcr.2007.12.017, PubMed 18262180
The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis
Exp Cell Res, 313 (8), 1696-709
DOI 10.1016/j.yexcr.2007.02.017, PubMed 17382318
EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae
Traffic, 7 (11), 1518-27
DOI 10.1111/j.1600-0854.2006.00487.x, PubMed 16984407
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Exp Cell Res, 312 (16), 3036-48
DOI 10.1016/j.yexcr.2006.06.004, PubMed 16859684
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits
Mol Cell Biol, 26 (2), 389-401
DOI 10.1128/MCB.26.2.389-401.2006, PubMed 16382132
The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane
Mol Biol Cell, 16 (12), 5832-42
DOI 10.1091/mbc.e05-05-0456, PubMed 16207817
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2
Int J Cancer, 116 (3), 359-67
DOI 10.1002/ijc.21015, PubMed 15800944
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation
Exp Cell Res, 300 (2), 388-95
DOI 10.1016/j.yexcr.2004.07.003, PubMed 15475003
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits
Mol Biol Cell, 15 (8), 3591-604
DOI 10.1091/mbc.e04-01-0041, PubMed 15194809
CD7 expression by CD34+ cells in CML patients, of prognostic significance?
Eur J Haematol, 71 (4), 266-75
DOI 10.1034/j.1600-0609.2003.00133.x, PubMed 12950236
Phosphorylation of Hrs downstream of the epidermal growth factor receptor
Eur J Biochem, 269 (16), 3881-7
DOI 10.1046/j.1432-1033.2002.03046.x, PubMed 12180964
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
Nat Cell Biol, 4 (5), 394-8
DOI 10.1038/ncb791, PubMed 11988743
Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae
J Cell Sci, 115 (Pt 6), 1331-40
DOI 10.1242/jcs.115.6.1331, PubMed 11884532
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
J Cell Biol, 156 (5), 843-54
DOI 10.1083/jcb.200106056, PubMed 11864992
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms
Biochem J, 356 (Pt 1), 87-96
DOI 10.1042/0264-6021:3560087, PubMed 11336639
Epidermal growth factor receptor efficiently activates mitogen-activated protein kinase in HeLa cells and Hep2 cells conditionally defective in clathrin-dependent endocytosis
Exp Cell Res, 260 (1), 136-45
DOI 10.1006/excr.2000.5004, PubMed 11010818
Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation
J Biol Chem, 275 (18), 13940-7
DOI 10.1074/jbc.275.18.13940, PubMed 10788520
Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein
Biochem J, 337 ( Pt 3) (Pt 3), 599-606
DOI 10.1042/0264-6021:3370599, PubMed 9895307
Alteration of G1 cell-cycle protein expression and induction of p53 but not p21/waf1 by the DNA-modifying carcinogen 2-acetylaminofluorene in growth-stimulated hepatocytes in vitro
Mol Carcinog, 24 (1), 36-46
DOI 10.1002/(sici)1098-2744(199901)24:1<36::aid-mc6>3.0.co;2-i, PubMed 10029409
One-tube multiplex RT-PCR of BCR-ABL transcripts in analysis of patients with chronic myeloid leukaemia and acute lymphoblastic leukaemia
Scand J Clin Lab Invest, 58 (8), 647-54
DOI 10.1080/00365519850186076, PubMed 10088201
Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1
Exp Cell Res, 243 (1), 161-72
DOI 10.1006/excr.1998.4127, PubMed 9716460
High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A)
J Biol Chem, 273 (27), 16639-42
DOI 10.1074/jbc.273.27.16639, PubMed 9642213
Diphtheria toxin can be used as a vehicle for bringing other proteins into cells
Restor Neurol Neurosci, 8 (1), 13-4
DOI 10.3233/RNN-1995-81204, PubMed 21551798
The N-terminal alpha-helix of fragment B of diphtheria toxin promotes translocation of fragment A into the cytoplasm of eukaryotic cells
J Biol Chem, 269 (26), 17723-9
PubMed 8021285
Dual mode of signal transduction by externally added acidic fibroblast growth factor
Cell, 76 (6), 1039-51
DOI 10.1016/0092-8674(94)90381-6, PubMed 7511061
Inhibition of membrane translocation of diphtheria toxin A-fragment by internal disulfide bridges
J Biol Chem, 269 (11), 8402-7
PubMed 8132565
Intermediates in translocation of diphtheria toxin across the plasma membrane
J Biol Chem, 269 (6), 4648-52
PubMed 7508447
Subcloning and characterization of the binding domain of fragment B of diphtheria toxin
Biochem J, 294 ( Pt 3) (Pt 3), 663-6
DOI 10.1042/bj2940663, PubMed 8379922
Membrane translocation of diphtheria toxin A-fragment: role of carboxy-terminal region
Biochemistry, 32 (1), 83-90
DOI 10.1021/bi00052a012, PubMed 8418864
Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector
EMBO J, 11 (13), 4835-42
DOI 10.1002/j.1460-2075.1992.tb05589.x, PubMed 1281450
Membrane translocation of diphtheria toxin carrying passenger protein domains
Infect Immun, 60 (8), 3296-302
DOI 10.1128/iai.60.8.3296-3302.1992, PubMed 1639497
Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment. Effect on membrane translocation and on formation of cation channels
J Biol Chem, 267 (17), 12284-90
PubMed 1376320
Entry of diphtheria toxin-protein A chimeras into cells
J Biol Chem, 266 (26), 17446-53
PubMed 1894632
Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol
J Cell Biol, 113 (5), 1025-32
DOI 10.1083/jcb.113.5.1025, PubMed 2040642
Elimination of the disulphide bridge in fragment B of diphtheria toxin: effect on membrane insertion, channel formation, and ATP binding
Mol Microbiol, 5 (3), 595-606
DOI 10.1111/j.1365-2958.1991.tb00730.x, PubMed 1646374
Effects of eliminating a disulfide bridge within domain II of Pseudomonas aeruginosa exotoxin A
Infect Immun, 57 (7), 1873-8
DOI 10.1128/iai.57.7.1873-1878.1989, PubMed 2499539
Selective inhibition of sodium-linked and sodium-independent bicarbonate/chloride antiport in Vero cells
J Biol Chem, 262 (16), 7486-91
PubMed 3584123
Formation and activity of covalent conjugates of poliovirus and ligands binding to cell surface structures
Exp Cell Res, 170 (2), 483-90
DOI 10.1016/0014-4827(87)90322-3, PubMed 3036553
Effect of potassium depletion of Hep 2 cells on intracellular pH and on chloride uptake by anion antiport
J Cell Physiol, 131 (1), 6-13
DOI 10.1002/jcp.1041310103, PubMed 3571337
Effect of reduced endocytosis induced by hypotonic shock and potassium depletion on the infection of Hep 2 cells by picornaviruses
J Cell Physiol, 131 (1), 14-22
DOI 10.1002/jcp.1041310104, PubMed 3032992
Different pH requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus
Virology, 139 (2), 346-57
DOI 10.1016/0042-6822(84)90380-5, PubMed 6097029
Requirements for entry of poliovirus RNA into cells at low pH
EMBO J, 3 (9), 1945-50
DOI 10.1002/j.1460-2075.1984.tb02074.x, PubMed 6092049
Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus
Biochem J, 219 (3), 935-40
DOI 10.1042/bj2190935, PubMed 6331401
Mechanism of entry into the cytosol of poliovirus type 1: requirement for low pH
J Cell Biol, 98 (4), 1194-200
DOI 10.1083/jcb.98.4.1194, PubMed 6325467
Review articles
Epidermal growth factor receptor and cancer: control of oncogenic signalling by endocytosis
J Cell Mol Med, 12 (5A), 1527-34
DOI 10.1111/j.1582-4934.2008.00298.x, PubMed 18318691
Entry of ADP-ribosylating toxins into cells
Curr Top Microbiol Immunol, 175, 1-26
DOI 10.1007/978-3-642-76966-5_1, PubMed 1378368
Protein toxins with intracellular targets
Microb Pathog, 8 (3), 163-8
DOI 10.1016/0882-4010(90)90043-p, PubMed 1696341
Regulation of intracellular pH in eukaryotic cells
Biochem J, 250 (1), 1-8
DOI 10.1042/bj2500001, PubMed 2965576
Entry mechanisms of protein toxins and picornaviruses
Biochem Soc Symp, 50, 171-91
PubMed 3915869
Other articles
Ubiquitin binding in endocytosis--how tight should it be and where does it happen?
Traffic, 7 (3), 258-61
DOI 10.1111/j.1600-0854.2006.00393.x, PubMed 16497221
Localizing the EGF receptor
Nat Cell Biol, 4 (2), E22; author reply E22-3
DOI 10.1038/ncb0202-e22a, PubMed 11835048
Tumor-promoting phorbol esters and vanadate alter the sensitivity of HeLa S3 cells to poliovirus type 1
Exp Cell Res, 160 (1), 240-4
DOI 10.1016/0014-4827(85)90253-8, PubMed 2995095
Books
Signalling from internalized growth factor receptors
Springer, Berlin, 185 s.
BIBSYS 041805305, ISBN 3-540-21038-5
Entry of picornaviruses into cells
[I. H. Madshus], Oslo, 1 b. (flere pag.)
BIBSYS 872028313