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Publications by Anne Pharo

44 publications found

Original articles

Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS (2019)
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin
Nat Immunol, 20 (12), 1644-1655
DOI 10.1038/s41590-019-0504-0, PubMed 31636468

Harboe M, Johnson C, Nymo S, Ekholt K, Schjalm C, Lindstad JK, Pharo A, Hellerud BC, Nilsson Ekdahl K, Mollnes TE, Nilsson PH (2017)
Properdin binding to complement activating surfaces depends on initial C3b deposition
Proc Natl Acad Sci U S A, 114 (4), E534-E539
DOI 10.1073/pnas.1612385114, PubMed 28069958

Khan F, Pharo A, Lindstad JK, Mollnes TE, Tønnessen TI, Pischke SE (2015)
Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis
Scand J Immunol, 82 (5), 467-75
DOI 10.1111/sji.12332, PubMed 26099791

Egge KH, Barratt-Due A, Nymo S, Lindstad JK, Pharo A, Lau C, Espevik T, Thorgersen EB, Mollnes TE (2015)
The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load
Clin Exp Immunol, 181 (3), 457-67
DOI 10.1111/cei.12645, PubMed 25907631

Egge KH, Thorgersen EB, Pischke SE, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn MA, Barratt-Due A, Mollnes TE (2015)
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14
Immunobiology, 220 (8), 999-1005
DOI 10.1016/j.imbio.2015.04.002, PubMed 25956456

Lau C, Gunnarsen KS, Høydahl LS, Andersen JT, Berntzen G, Pharo A, Lindstad JK, Ludviksen JK, Brekke OL, Barratt-Due A, Nielsen EW, Stokes CR, Espevik T, Sandlie I, Mollnes TE (2013)
Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation
J Immunol, 191 (9), 4769-77
DOI 10.4049/jimmunol.1301653, PubMed 24062486

Thorgersen EB, Pischke SE, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Hellerud BC, Mollnes TE (2013)
Systemic CD14 inhibition attenuates organ inflammation in porcine Escherichia coli sepsis
Infect Immun, 81 (9), 3173-81
DOI 10.1128/IAI.00390-13, PubMed 23774598

Barratt-Due A, Thorgersen EB, Egge K, Pischke S, Sokolov A, Hellerud BC, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn M, Scott H, Mollnes TE (2013)
Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis
J Immunol, 191 (2), 819-27
DOI 10.4049/jimmunol.1201909, PubMed 23761634

Egge KH, Thorgersen EB, Lindstad JK, Pharo A, Lambris JD, Barratt-Due A, Mollnes TE (2013)
Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood
Innate Immun, 20 (1), 68-77
DOI 10.1177/1753425913482993, PubMed 23669326

Haugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Waelgaard L, Pischke SE, Mollnes TE, Inge Tønnessen T (2012)
Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts
Liver Transpl, 18 (12), 1421-9
DOI 10.1002/lt.23503, PubMed 22767413

Barratt-Due A, Sokolov A, Gustavsen A, Hellerud BC, Egge K, Pischke SE, Lindstad JK, Pharo A, Castellheim A, Thorgersen EB, Mollnes TE (2012)
Polyvalent immunoglobulin significantly attenuated the formation of IL-1β in Escherichia coli-induced sepsis in pigs
Immunobiology, 218 (5), 683-9
DOI 10.1016/j.imbio.2012.08.268, PubMed 22947599

Harboe M, Garred P, Lindstad JK, Pharo A, Müller F, Stahl GL, Lambris JD, Mollnes TE (2012)
The role of properdin in zymosan- and Escherichia coli-induced complement activation
J Immunol, 189 (5), 2606-13
DOI 10.4049/jimmunol.1200269, PubMed 22851705

Håugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2012)
Early bedside detection of ischemia and rejection in liver transplants by microdialysis
Liver Transpl, 18 (7), 839-49
DOI 10.1002/lt.23425, PubMed 22407878

Barratt-Due A, Johansen HT, Sokolov A, Thorgersen EB, Hellerud BC, Reubsaet JL, Seip KF, Tønnessen TI, Lindstad JK, Pharo A, Castellheim A, Mollnes TE, Nielsen EW (2011)
The role of bradykinin and the effect of the bradykinin receptor antagonist icatibant in porcine sepsis
Shock, 36 (5), 517-23
DOI 10.1097/SHK.0b013e3182336a34, PubMed 21921836

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Lissina O, Lambris JD, Nunn MA, Mollnes TE (2011)
Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans
J Immunol, 187 (9), 4913-9
DOI 10.4049/jimmunol.1101000, PubMed 21964028

Brekke OL, Hellerud BC, Christiansen D, Fure H, Castellheim A, Nielsen EW, Pharo A, Lindstad JK, Bergseth G, Leslie G, Lambris JD, Brandtzaeg P, Mollnes TE (2011)
Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood
Mol Immunol, 48 (15-16), 2159-69
DOI 10.1016/j.molimm.2011.07.011, PubMed 21839519

Sokolov A, Hellerud BC, Pharo A, Johannessen EA, Mollnes TE (2011)
Complement activation by candidate biomaterials of an implantable microfabricated medical device
J Biomed Mater Res B Appl Biomater, 98 (2), 323-9
DOI 10.1002/jbm.b.31855, PubMed 21648060

Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tønnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P (2010)
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis
Crit Care Med, 38 (6), 1467-74
DOI 10.1097/CCM.0b013e3181de8c94, PubMed 20400898

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Brekke OL, Christiansen D, Lambris JD, Mollnes TE (2010)
Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood
Mol Immunol, 47 (9), 1774-82
DOI 10.1016/j.molimm.2010.02.026, PubMed 20334922

Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tønnessen TI, Johansen HT, Castellheim A, Mollnes TE (2009)
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs
FASEB J, 24 (3), 712-22
DOI 10.1096/fj.09-140798, PubMed 19841036

Nielsen EW, Hellerud BC, Thorgersen EB, Castellheim A, Pharo A, Lindstad J, Tønnessen TI, Brandtzaeg P, Mollnes TE (2009)
A new dynamic porcine model of meningococcal shock
Shock, 32 (3), 302-9
DOI 10.1097/SHK.0b013e31819c37be, PubMed 19174740

Lappegård KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, Lindstad J, Nielsen EW, Bergseth G, Fadnes D, Abrahamsen TG, Høiby EA, Schejbel L, Garred P, Lambris JD, Harboe M, Mollnes TE (2009)
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature
Proc Natl Acad Sci U S A, 106 (37), 15861-6
DOI 10.1073/pnas.0903613106, PubMed 19717455

Thorgersen EB, Pharo A, Haverson K, Axelsen AK, Gaustad P, Kotwal GJ, Sfyroera G, Mollnes TE (2008)
Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood
Infect Immun, 77 (2), 725-32
DOI 10.1128/IAI.01305-08, PubMed 19047409

Lappegård KT, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris JD, Mollnes TE (2008)
The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent
J Biomed Mater Res A, 87 (1), 129-35
DOI 10.1002/jbm.a.31750, PubMed 18085644

Brekke OL, Christiansen D, Fure H, Pharo A, Fung M, Riesenfeld J, Mollnes TE (2008)
Combined inhibition of complement and CD14 abolish E. coli-induced cytokine-, chemokine- and growth factor-synthesis in human whole blood
Mol Immunol, 45 (14), 3804-13
DOI 10.1016/j.molimm.2008.05.017, PubMed 18606453

Castellheim A, Hoel TN, Videm V, Fosse E, Pharo A, Svennevig JL, Fiane AE, Mollnes TE (2008)
Biomarker profile in off-pump and on-pump coronary artery bypass grafting surgery in low-risk patients
Ann Thorac Surg, 85 (6), 1994-2002
DOI 10.1016/j.athoracsur.2008.03.012, PubMed 18498809

Castellheim A, Thorgersen EB, Hellerud BC, Pharo A, Johansen HT, Brosstad F, Gaustad P, Brun H, Fosse E, Tønnessen TI, Nielsen EW, Mollnes TE (2008)
New biomarkers in an acute model of live Escherichia coli-induced sepsis in pigs
Scand J Immunol, 68 (1), 75-84
DOI 10.1111/j.1365-3083.2008.02122.x, PubMed 18466195

Waelgaard L, Pharo A, Tønnessen TI, Mollnes TE (2006)
Microdialysis for monitoring inflammation: efficient recovery of cytokines and anaphylotoxins provided optimal catheter pore size and fluid velocity conditions
Scand J Immunol, 64 (3), 345-52
DOI 10.1111/j.1365-3083.2006.01826.x, PubMed 16918704

Frøyland E, Pedersen ED, Kvissel AK, Almaas R, Pharo A, Skålhegg BS, Mollnes TE, Rootwelt T (2006)
Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons
Brain Res, 1113 (1), 64-73
DOI 10.1016/j.brainres.2006.07.051, PubMed 16919250

Castellheim A, Lindenskov PH, Pharo A, Aamodt G, Saugstad OD, Mollnes TE (2005)
Meconium aspiration syndrome induces complement-associated systemic inflammatory response in newborn piglets
Scand J Immunol, 61 (3), 217-25
DOI 10.1111/j.1365-3083.2005.01532.x, PubMed 15787738

Castellheim A, Pharo A, Fung M, Saugstad OD, Mollnes TE (2004)
Complement C5a is a key mediator of meconium-induced neutrophil activation
Pediatr Res, 57 (2), 242-7
DOI 10.1203/01.PDR.0000150725.78971.30, PubMed 15585680

Castellheim A, Lindenskov PH, Pharo A, Fung M, Saugstad OD, Mollnes TE (2003)
Meconium is a potent activator of complement in human serum and in piglets
Pediatr Res, 55 (2), 310-8
DOI 10.1203/01.PDR.0000100902.76021.8E, PubMed 14605246

Gundersen Y, Vaagenes P, Myhre O, Andersen JM, Pharo A, Haugen AH, Valoe E, Opstad PK (2003)
Hydrocortisone and the mitogen-activated protein kinase inhibitor U0126 acutely suppress reactive oxygen species generation from circulating granulocytes after gunshot injuries in the pig
Crit Care Med, 31 (1), 166-70
DOI 10.1097/00003246-200301000-00026, PubMed 12545011

Gundersen Y, Vaagenes P, Pharo A, Valø ET, Opstad PK (2001)
Moderate hypothermia blunts the inflammatory response and reduces organ injury after acute haemorrhage
Acta Anaesthesiol Scand, 45 (8), 994-1001
DOI 10.1034/j.1399-6576.2001.450812.x, PubMed 11576051

Aurlien E, Holte H, Pharo A, Kvaløy S, Jakobsen E, Smeland EB, Kvalheim G (1998)
Combination chemotherapy with mitoguazon, ifosfamide, MTX, etoposide (MIME) and G-CSF can efficiently mobilize PBPC in patients with Hodgkin's and non-Hodgkin's lymphoma
Bone Marrow Transplant, 21 (9), 873-8
DOI 10.1038/sj.bmt.1701192, PubMed 9613778

Kvalheim G, Pharo A, Holte H, Jakobsen E, Erikstein B, Kvaløy S, Beiske K, Nesland JM, Smeland EB (1996)
[High-dose therapy of cancer with CD34 positive cells as stem cell support]
Tidsskr Nor Laegeforen, 116 (21), 2542-6
PubMed 8928121

Myklebust AT, Godal A, Juell S, Pharo A, Fodstad O (1994)
Comparison of two antibody-based methods for elimination of breast cancer cells from human bone marrow
Cancer Res, 54 (1), 209-14
PubMed 7505198

Myklebust AT, Godal A, Pharo A, Juell S, Fodstad O (1993)
Eradication of small cell lung cancer cells from human bone marrow with immunotoxins
Cancer Res, 53 (16), 3784-8
PubMed 8393381

Myklebust AT, Pharo A, Fodstad O (1993)
Effective removal of SCLC cells from human bone marrow. Use of four monoclonal antibodies and immunomagnetic beads
Br J Cancer, 67 (6), 1331-6
DOI 10.1038/bjc.1993.246, PubMed 8390285

Myklebust AT, Beiske K, Pharo A, Davies CD, Aamdal S, Fodstad O (1991)
Selection of anti-SCLC antibodies for diagnosis of bone marrow metastasis
Br J Cancer Suppl, 14, 49-53
PubMed 1645572

MYKLEBUST AT, BEISKE K, PHARO A, DAVIES CD, AAMDAL S, FODSTAD O (1991)
SELECTION OF ANTI-SCLC ANTIBODIES FOR DIAGNOSIS OF BONE-MARROW METASTASIS
Br. J. Cancer, 63 14, 49-53

Kvalheim G, Fodstad O, Pihl A, Nustad K, Pharo A, Ugelstad J, Funderud S (1987)
Elimination of B-lymphoma cells from human bone marrow: model experiments using monodisperse magnetic particles coated with primary monoclonal antibodies
Cancer Res, 47 (3), 846-51
PubMed 3492268

Review articles

Kvalheim G, Wang MY, Pharo A, Holte H, Jacobsen E, Beiske K, Kvaløy S, Smeland E, Funderud S, Fodstad O (1996)
Purging of tumor cells from leukapheresis products: experimental and clinical aspects
J Hematother, 5 (4), 427-36
DOI 10.1089/scd.1.1996.5.427, PubMed 8877718

Books

Gundersen Y, Vaagenes P, Haugen AH, Pharo A, Valø ET, Myhre O, Andersen JM, Sundnes KO, Os Ø, Pillgram-Larsen J (2002)
Tidlig behandling med hydrokortison og/eller U-0126 hemmer syntesen av frie oksygenradikaler etter skuddskader hos gris
FFI, Kjeller, 16 s.
BIBSYS 020531664, ISBN 82-464-0581-0