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Publications by Burkhard Fleckenstein

51 publications found

Original articles

Teng H, Li C, Zhang Y, Lu M, Chopp M, Zhang ZG, Melcher-Mourgas M, Fleckenstein B (2021)
Therapeutic effect of Cerebrolysin on reducing impaired cerebral endothelial cell permeability
Neuroreport, 32 (5), 359-366
DOI 10.1097/WNR.0000000000001598, PubMed 33661804

Goerig N, Semrau S, Frey B, Korn K, Fleckenstein B, Überla K, Dörfler A, Putz F, Gaipl US, Fietkau R (2016)
Clinically significant CMV (re)activation during or after radiotherapy/chemotherapy of the brain : Correlation with neurological deterioration and improvement upon antiviral treatment
Strahlenther Onkol, 192 (7), 489-97
DOI 10.1007/s00066-016-0987-7, PubMed 27245820

Tutturen AE, Fleckenstein B, de Souza GA (2014)
Assessing the citrullinome in rheumatoid arthritis synovial fluid with and without enrichment of citrullinated peptides
J Proteome Res, 13 (6), 2867-73
DOI 10.1021/pr500030x, PubMed 24724574

Tutturen AE, Holm A, Fleckenstein B (2013)
Specific biotinylation and sensitive enrichment of citrullinated peptides
Anal Bioanal Chem, 405 (29), 9321-31
DOI 10.1007/s00216-013-7376-1, PubMed 24081567

Sørbø JG, Fleckenstein B, Ottersen OP, Holen T (2012)
Small-scale purification and mass spectrometry analysis reveal a third aquaporin-4 protein isoform of 36 kDa in rat brain
J Neurosci Methods, 211 (1), 31-9
DOI 10.1016/j.jneumeth.2012.07.021, PubMed 22967487

Benam AV, Lång E, Alfsnes K, Fleckenstein B, Rowe AD, Hovland E, Ambur OH, Frye SA, Tønjum T (2011)
Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation
Microbiology (Reading), 157 (Pt 5), 1329-1342
DOI 10.1099/mic.0.046896-0, PubMed 21330432

Jüse U, Arntzen M, Højrup P, Fleckenstein B, Sollid LM (2011)
Assessing high affinity binding to HLA-DQ2.5 by a novel peptide library based approach
Bioorg Med Chem, 19 (7), 2470-7
DOI 10.1016/j.bmc.2011.01.057, PubMed 21382721

Pollmann S, Stensland M, Halvorsen EH, Sollid LM, Kvien TK, Fleckenstein B, Molberg O (2011)
Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate
Rheumatol Int, 32 (5), 1271-6
DOI 10.1007/s00296-010-1765-y, PubMed 21267570

Dørum S, Arntzen MØ, Qiao SW, Holm A, Koehler CJ, Thiede B, Sollid LM, Fleckenstein B (2010)
The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes
PLoS One, 5 (11), e14056
DOI 10.1371/journal.pone.0014056, PubMed 21124911

Stamnaes J, Pinkas DM, Fleckenstein B, Khosla C, Sollid LM (2010)
Redox regulation of transglutaminase 2 activity
J Biol Chem, 285 (33), 25402-9
DOI 10.1074/jbc.M109.097162, PubMed 20547769

Tutturen AE, Holm A, Jørgensen M, Stadtmüller P, Rise F, Fleckenstein B (2010)
A technique for the specific enrichment of citrulline-containing peptides
Anal Biochem, 403 (1-2), 43-51
DOI 10.1016/j.ab.2010.04.012, PubMed 20399192

Stamnaes J, Dorum S, Fleckenstein B, Aeschlimann D, Sollid LM (2010)
Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia
Amino Acids, 39 (5), 1183-91
DOI 10.1007/s00726-010-0554-y, PubMed 20300788

Jüse U, van de Wal Y, Koning F, Sollid LM, Fleckenstein B (2010)
Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library
Hum Immunol, 71 (5), 475-81
DOI 10.1016/j.humimm.2010.01.021, PubMed 20105447

Stensland M, Holm A, Kiehne A, Fleckenstein B (2009)
Targeted analysis of protein citrullination using chemical modification and tandem mass spectrometry
Rapid Commun Mass Spectrom, 23 (17), 2754-62
DOI 10.1002/rcm.4185, PubMed 19639564

Dørum S, Qiao SW, Sollid LM, Fleckenstein B (2009)
A quantitative analysis of transglutaminase 2-mediated deamidation of gluten peptides: implications for the T-cell response in celiac disease
J Proteome Res, 8 (4), 1748-55
DOI 10.1021/pr800960n, PubMed 19239248

Lång E, Haugen K, Fleckenstein B, Homberset H, Frye SA, Ambur OH, Tønjum T (2009)
Identification of neisserial DNA binding components
Microbiology (Reading), 155 (Pt 3), 852-862
DOI 10.1099/mic.0.022640-0, PubMed 19246756

Stensland ME, Pollmann S, Molberg Ø, Sollid LM, Fleckenstein B (2009)
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4
Biol Chem, 390 (2), 99-107
DOI 10.1515/BC.2009.019, PubMed 19040354

Jüse U, Fleckenstein B, Bergseng E, Sollid LM (2008)
Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein
Immunogenetics, 61 (2), 81-9
DOI 10.1007/s00251-008-0338-7, PubMed 18987854

Fallang LE, Roh S, Holm A, Bergseng E, Yoon T, Fleckenstein B, Bandyopadhyay A, Mellins ED, Sollid LM (2008)
Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM
J Immunol, 181 (8), 5451-5461
DOI 10.4049/jimmunol.181.8.5451, PubMed 18832702

Stamnaes J, Fleckenstein B, Lund-Johansen F, Sollid LM (2008)
The monoclonal antibody 6B9 recognizes CD44 and not cell surface transglutaminase 2
Scand J Immunol, 68 (5), 534-42
DOI 10.1111/j.1365-3083.2008.02173.x, PubMed 18803608

Stamnaes J, Fleckenstein B, Sollid LM (2008)
The propensity for deamidation and transamidation of peptides by transglutaminase 2 is dependent on substrate affinity and reaction conditions
Biochim Biophys Acta, 1784 (11), 1804-11
DOI 10.1016/j.bbapap.2008.08.011, PubMed 18793760

Andersen JT, Justesen S, Fleckenstein B, Michaelsen TE, Berntzen G, Kenanova VE, Daba MB, Lauvrak V, Buus S, Sandlie I (2008)
Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues
FEBS J, 275 (16), 4097-110
DOI 10.1111/j.1742-4658.2008.06551.x, PubMed 18637944

Granum S, Andersen TC, Sørlie M, Jørgensen M, Koll L, Berge T, Lea T, Fleckenstein B, Spurkland A, Sundvold-Gjerstad V (2008)
Modulation of Lck function through multisite docking to T cell-specific adapter protein
J Biol Chem, 283 (32), 21909-19
DOI 10.1074/jbc.M800871200, PubMed 18541536

Andersen JT, Justesen S, Berntzen G, Michaelsen TE, Lauvrak V, Fleckenstein B, Buus S, Sandlie I (2007)
A strategy for bacterial production of a soluble functional human neonatal Fc receptor
J Immunol Methods, 331 (1-2), 39-49
DOI 10.1016/j.jim.2007.11.003, PubMed 18155020

Xia J, Bergseng E, Fleckenstein B, Siegel M, Kim CY, Khosla C, Sollid LM (2007)
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
Bioorg Med Chem, 15 (20), 6565-73
DOI 10.1016/j.bmc.2007.07.001, PubMed 17681795

Pfeiffer-Guglielmi B, Coles JA, Francke M, Reichenbach A, Fleckenstein B, Jung G, Nicaise G, Hamprecht B (2006)
Immunocytochemical analysis of rat vagus nerve by antibodies against glycogen phosphorylase isozymes
Brain Res, 1110 (1), 23-9
DOI 10.1016/j.brainres.2006.06.080, PubMed 16879805

Tollefsen S, Arentz-Hansen H, Fleckenstein B, Molberg O, Ráki M, Kwok WW, Jung G, Lundin KE, Sollid LM (2006)
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease
J Clin Invest, 116 (8), 2226-36
DOI 10.1172/JCI27620, PubMed 16878175

Pepaj M, Holm A, Fleckenstein B, Lundanes E, Greibrokk T (2006)
Fractionation and separation of human salivary proteins by pH-gradient ion exchange and reversed phase chromatography coupled to mass spectrometry
J Sep Sci, 29 (4), 519-28
DOI 10.1002/jssc.200500346, PubMed 16583690

Holm A, Rise F, Sessler N, Sollid LM, Undheim K, Fleckenstein B (2006)
Specific modification of peptide-bound citrulline residues
Anal Biochem, 352 (1), 68-76
DOI 10.1016/j.ab.2006.02.007, PubMed 16540076

Braathen R, Sandvik A, Berntzen G, Hammerschmidt S, Fleckenstein B, Sandlie I, Brandtzaeg P, Johansen FE, Lauvrak V (2006)
Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition
J Biol Chem, 281 (11), 7075-81
DOI 10.1074/jbc.M508509200, PubMed 16423833

Qiao SW, Bergseng E, Molberg O, Jung G, Fleckenstein B, Sollid LM (2005)
Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation
J Immunol, 175 (1), 254-61
DOI 10.4049/jimmunol.175.1.254, PubMed 15972656

Wieser C, Stumpf D, Grillhösl C, Lengenfelder D, Gay S, Fleckenstein B, Ensser A (2005)
Regulated and constitutive expression of anti-inflammatory cytokines by nontransforming herpesvirus saimiri vectors
Gene Ther, 12 (5), 395-406
DOI 10.1038/sj.gt.3302424, PubMed 15647772

Molberg O, Uhlen AK, Jensen T, Flaete NS, Fleckenstein B, Arentz-Hansen H, Raki M, Lundin KE, Sollid LM (2005)
Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease
Gastroenterology, 128 (2), 393-401
DOI 10.1053/j.gastro.2004.11.003, PubMed 15685550

Qiao SW, Piper J, Haraldsen G, Oynebråten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM (2005)
Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease
J Immunol, 174 (3), 1657-63
DOI 10.4049/jimmunol.174.3.1657, PubMed 15661929

Fleckenstein B, Qiao SW, Larsen MR, Roepstorff P, Sollid LM, Jung G (2005)
Molecular characterization of covalent transglutaminase (TG2)-gliadin peptide complexes involved in coeliac disease
Peptides 2004, Proceedings: BRIDGES BETWEEN DISCIPLINES, 73-74

Pfeiffer-Guglielmi B, Francke M, Reichenbach A, Fleckenstein B, Jung G, Hamprecht B (2005)
Glycogen phosphorylase isozyme pattern in mammalian retinal Müller (glial) cells and in astrocytes of retina and optic nerve
Glia, 49 (1), 84-95
DOI 10.1002/glia.20102, PubMed 15390095

Arentz-Hansen H, Fleckenstein B, Molberg Ø, Scott H, Koning F, Jung G, Roepstorff P, Lundin KE, Sollid LM (2004)
The molecular basis for oat intolerance in patients with celiac disease
PLoS Med, 1 (1), e1
DOI 10.1371/journal.pmed.0010001, PubMed 15526039

Qiao SW, Bergseng E, Molberg Ø, Xia J, Fleckenstein B, Khosla C, Sollid LM (2004)
Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
J Immunol, 173 (3), 1757-62
DOI 10.4049/jimmunol.173.3.1757, PubMed 15265905

Volz T, Schwarz G, Fleckenstein B, Schepp CP, Haug M, Roth J, Wiesmüller KH, Dannecker GE (2004)
Determination of the peptide binding motif and high-affinity ligands for HLA-DQ4 using synthetic peptide libraries
Hum Immunol, 65 (6), 594-601
DOI 10.1016/j.humimm.2004.02.027, PubMed 15219379

Meins M, Böhm D, Großmann A, Herting E, Fleckenstein B, Fauth C, Speicher MR, Schindler R, Zoll B, Bartels I, Burfeind P (2004)
First non-mosaic case of isopseudodicentric chromosome 18 (psu idic(18)(pter --> q22.1::q22.1 --> pter) is associated with multiple congenital anomalies reminiscent of trisomy 18 and 18q- syndrome
Am J Med Genet A, 127A (1), 58-64
DOI 10.1002/ajmg.a.20644, PubMed 15103719

Fleckenstein B, Qiao SW, Larsen MR, Jung G, Roepstorff P, Sollid LM (2004)
Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides
J Biol Chem, 279 (17), 17607-16
DOI 10.1074/jbc.M310198200, PubMed 14747475

Gregers TF, Fleckenstein B, Vartdal F, Roepstorff P, Bakke O, Sandlie I (2003)
MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation
Int Immunol, 15 (11), 1291-9
DOI 10.1093/intimm/dxg128, PubMed 14565927

Schjetne KW, Thompson KM, Nilsen N, Flo TH, Fleckenstein B, Iversen JG, Espevik T, Bogen B (2003)
Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target
J Immunol, 171 (1), 32-6
DOI 10.4049/jimmunol.171.1.32, PubMed 12816980

Pfeiffer-Guglielmi B, Fleckenstein B, Jung G, Hamprecht B (2003)
Immunocytochemical localization of glycogen phosphorylase isozymes in rat nervous tissues by using isozyme-specific antibodies
J Neurochem, 85 (1), 73-81
DOI 10.1046/j.1471-4159.2003.01644.x, PubMed 12641728

Sollid LM, Arentz-Hansen H, Fleckenstein B, Lundin KEA, McAdam S, Molberg O, Qiao SW, Quarsten H (2003)
The T cell response to gluten and control of coeliac disease development
COELIAC DISEASE, 71-76

Ihle J, Fleckenstein B, Terreaux C, Beck H, Albert ED, Dannecker GE (2003)
Differential peptide binding motif for three juvenile arthritis associated HLA-DQ molecules
Clin Exp Rheumatol, 21 (2), 257-62
PubMed 12747287

Schjetne KW, Thompson KM, Aarvak T, Fleckenstein B, Sollid LM, Bogen B (2002)
A mouse C kappa-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation
Int Immunol, 14 (12), 1423-30
DOI 10.1093/intimm/dxf110, PubMed 12456590

Kröger K, Bauer J, Fleckenstein B, Rademann J, Jung G, Gauglitz G (2002)
Epitope-mapping of transglutaminase with parallel label-free optical detection
Biosens Bioelectron, 17 (11-12), 937-44
DOI 10.1016/s0956-5663(02)00085-4, PubMed 12392942

Arentz-Hansen H, McAdam SN, Molberg Ø, Fleckenstein B, Lundin KE, Jørgensen TJ, Jung G, Roepstorff P, Sollid LM (2002)
Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues
Gastroenterology, 123 (3), 803-9
DOI 10.1053/gast.2002.35381, PubMed 12198706

Fleckenstein B, Molberg Ø, Qiao SW, Schmid DG, von der Mülbe F, Elgstøen K, Jung G, Sollid LM (2002)
Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process
J Biol Chem, 277 (37), 34109-16
DOI 10.1074/jbc.M204521200, PubMed 12093810

Brinker A, Scheufler C, Von Der Mulbe F, Fleckenstein B, Herrmann C, Jung G, Moarefi I, Hartl FU (2002)
Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes
J Biol Chem, 277 (22), 19265-75
DOI 10.1074/jbc.M109002200, PubMed 11877417