RSS feed

Publications from OUS - Norwegian PSC Research Center

390 publications found

Publications 2024

Gregersen I, Kong XY, Kooijman S, Foyn H, Grannes H, Olsen MB, Lone AM, Yang K, Quiles-Jiménez A, Tran M, Øgaard J, Segers FM, Rashidi A, Sagen EL, Lauritzen KH, Pronk ACM, de Boer JF, Holven KB, Melum E, Aukrust P, Taskén K, Holm S, Rensen PCN, Dahl TB, Halvorsen B (2024)
T cells with increased responsiveness cause obesity in mice without diet intervention
iScience, 27 (4), 109471
DOI 10.1016/j.isci.2024.109471, PubMed 38551005

He MM, Wang K, Lo CH, Zhang Y, Polychronidis G, Knudsen MD, Zhong R, Ma Y, Wu K, Chan AT, Giovannucci EL, Ogino S, Ng K, Meyerhardt JA, Song M (2024)
Post-diagnostic multivitamin supplement use and colorectal cancer survival: A prospective cohort study
Cancer (in press)
DOI 10.1002/cncr.35234, PubMed 38319287

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS (2024)
Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Nature, 626 (8001), E19
DOI 10.1038/s41586-024-07164-y, PubMed 38336833

Jaeger JW, Brandt A, Gui W, Yergaliyev T, Hernández-Arriaga A, Muthu MM, Edlund K, Elashy A, Molinaro A, Möckel D, Sarges J, Halibasic E, Trauner M, Kahles F, Rolle-Kampczyk U, Hengstler J, Schneider CV, Lammers T, Marschall HU, von Bergen M, Camarinha-Silva A, Bergheim I, Trautwein C, Schneider KM (2024)
Microbiota modulation by dietary oat beta-glucan prevents steatotic liver disease progression
JHEP Rep, 6 (3), 100987
DOI 10.1016/j.jhepr.2023.100987, PubMed 38328439

Jørgensen SF, Macpherson ME, Bjørnetrø T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Trøseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B (2024)
Retraction Note: Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 14 (1), 3704
DOI 10.1038/s41598-024-54117-6, PubMed 38355714

Karlsen TH, Rutter H, Carrieri P, Zelber-Sagi S, Engebretsen E, Hutchinson S, Voigt K, Guha N, Berzigotti A, Schomerus G, Gines P, Buti M, Burra P, Manns MP, Krag A, Kleinert S (2024)
The EASL-Lancet Commission on liver health in Europe: prevention, case-finding, and early diagnosis to reduce liver-related mortality
Lancet, 403 (10436), 1522-1524
DOI 10.1016/S0140-6736(24)00204-6, PubMed 38359860

Lin W, Gerullat L, Braadland PR, Fournier A, Hov JR, Globisch D (2024)
Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4-Nitrophenyl-2H-azirine
Angew Chem Int Ed Engl, 63 (14), e202318579
DOI 10.1002/anie.202318579, PubMed 38235602

Nikitina D, Lukosevicius R, Tilinde D, Muskieta T, Hov JR, Melum E, Klovins J, Org E, Kiudelis G, Kupcinskas J, Skieceviciene J (2024)
Cell-Free Microbial DNA Analysis: Effects of Blood Plasma and Serum Quantity, Biobanking Protocols, and Isolation Kits
Biopreserv Biobank (in press)
DOI 10.1089/bio.2023.0048, PubMed 38416864

Oldereid TS, Jiang X, Øgaard J, Schrumpf E, Bjørnholt JV, Rasmussen H, Melum E (2024)
Microbial exposure during early life regulates development of bile duct inflammation
Scand J Gastroenterol, 59 (2), 192-201
DOI 10.1080/00365521.2023.2278423, PubMed 37997753

Raju SC, Molinaro A, Awoyemi A, Jørgensen SF, Braadland PR, Nendl A, Seljeflot I, Ueland PM, McCann A, Aukrust P, Vestad B, Mayerhofer C, Broch K, Gullestad L, Lappegård KT, Halvorsen B, Kristiansen K, Hov JR, Trøseid M (2024)
Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity
Genome Med, 16 (1), 27
DOI 10.1186/s13073-024-01296-6, PubMed 38331891

Serrano-Villar S, Tincati C, Raju SC, Sáenz JS, Moreno E, Bargiela R, Cabello-Ubeda A, Sendagorta E, Kurz A, Perez Molina JA, de Benito A, Hov JR, Fernandez-Lopez L, Muriel A, Del Campo R, Moreno S, Trøseid M, Seifert J, Ferrer M (2024)
Author Correction: Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer
Nat Med, 30 (1), 303
DOI 10.1038/s41591-023-02529-8, PubMed 37587221

Trøseid M, Molinaro A, Gelpi M, Vestad B, Kofoed KF, Fuchs A, Køber L, Holm K, Benfield T, Ueland PM, Hov JR, Nielsen SD, Knudsen AD (2024)
Gut Microbiota Alterations and Circulating Imidazole Propionate Levels Are Associated With Obstructive Coronary Artery Disease in People With HIV
J Infect Dis, 229 (3), 898-907
DOI 10.1093/infdis/jiad604, PubMed 38195204

Publications 2023

Al Khatib I, Deng J, Lei Y, Torres-Odio S, Rojas GR, Newman LE, Chung BK, Symes A, Zhang H, Huang SN, Pommier Y, Khan A, Shadel GS, West AP, Gibson WT, Shutt TE (2023)
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
Hum Mol Genet, 32 (15), 2422-2440
DOI 10.1093/hmg/ddad062, PubMed 37129502

Andersen IM, Reims HM, Grzyb K, Fevang B, Melum E, Aukrust P, Wiencke K, Nordøy I, Line PD, Jørgensen SF (2023)
Long-term survival after liver transplantation in patients with common variable immunodeficiency
Liver Transpl, 29 (8), 894-899
DOI 10.1097/LVT.0000000000000130, PubMed 36932715

Bergsmark T, Engesæter LK, Rasmussen A, Bennet W, Nordin A, Pall V, Line PD, Ericzon BG, Melum E (2023)
Long-term survival after liver transplantation for alcohol-related liver disease in the Nordic countries
Scand J Gastroenterol, 58 (8), 923-930
DOI 10.1080/00365521.2023.2184193, PubMed 36872559

Braadland PR, Bergquist A, Kummen M, Bossen L, Engesæter LK, Reims HM, Björk I, Grzyb K, Abildgaard A, Småstuen MC, Folseraas T, Trøseid M, Ulvik A, Ueland PM, Melum E, Line PD, Høivik ML, Grønbæk H, Karlsen TH, Vesterhus M, Hov JR (2023)
Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation
J Hepatol, 79 (4), 955-966
DOI 10.1016/j.jhep.2023.05.038, PubMed 37328069

Busek M, Aizenshtadt A, Koch T, Frank A, Delon L, Martinez MA, Golovin A, Dumas C, Stokowiec J, Gruenzner S, Melum E, Krauss S (2023)
Pump-less, recirculating organ-on-a-chip (rOoC) platform
Lab Chip, 23 (4), 591-608
DOI 10.1039/d2lc00919f, PubMed 36655405

Carbone M, Della Penna A, Mazzarelli C, De Martin E, Villard C, Bergquist A, Line PD, Neuberger JM, Al-Shakhshir S, Trivedi PJ, Baumann U, Cristoferi L, Hov J, Fischler B, Hadzic NH, Debray D, D'Antiga L, Selzner N, Belli LS, Nadalin S (2023)
Liver Transplantation for Primary Sclerosing Cholangitis (PSC) With or Without Inflammatory Bowel Disease (IBD)-A European Society of Organ Transplantation (ESOT) Consensus Statement
Transpl Int, 36, 11729
DOI 10.3389/ti.2023.11729, PubMed 37841645

De Muynck K, Heyerick L, De Ponti FF, Vanderborght B, Meese T, Van Campenhout S, Baudonck L, Gijbels E, Rodrigues PM, Banales JM, Vesterhuus M, Folseraas T, Scott CL, Vinken M, Van der Linden M, Hoorens A, Van Dorpe J, Lefere S, Geerts A, Van Nieuwerburgh F, Verhelst X, Van Vlierberghe H, Devisscher L (2023)
Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis
Hepatology, 79 (2), 269-288
DOI 10.1097/HEP.0000000000000557, PubMed 37535809

Ecklu-Mensah G, Choo-Kang C, Maseng MG, Donato S, Bovet P, Viswanathan B, Bedu-Addo K, Plange-Rhule J, Oti Boateng P, Forrester TE, Williams M, Lambert EV, Rae D, Sinyanya N, Luke A, Layden BT, O'Keefe S, Gilbert JA, Dugas LR (2023)
Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study
Nat Commun, 14 (1), 5160
DOI 10.1038/s41467-023-40874-x, PubMed 37620311

Gjersvik P, Falk RS, Roscher I, Rizvi SMH, Mjøen G, Gude E, Leuckfeld I, Boberg KM, Veierød MB, Robsahm TE (2023)
Rates of Second Tumor, Metastasis, and Death From Cutaneous Squamous Cell Carcinoma in Patients With and Without Transplant-Associated Immunosuppression
JAMA Dermatol, 159 (9), 923-929
DOI 10.1001/jamadermatol.2023.2029, PubMed 37466985

Grant CW, Juran BD, Ali AH, Schlicht EM, Bianchi JK, Hu X, Liang Y, Jarrell Z, Liu KH, Go YM, Jones DP, Walker DI, Miller GW, Folseraas T, Karlsen TH, LaRusso NF, Gores GJ, Athreya AP, Lazaridis KN (2023)
Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis
Exposome, 3 (1), osac011
DOI 10.1093/exposome/osac011, PubMed 36687160

Graupera I, Thiele M, Ma AT, Serra-Burriel M, Pich J, Fabrellas N, Caballeria L, de Knegt RJ, Grgurevic I, Reichert M, Roulot D, Schattenberg JM, Pericas JM, Angeli P, Tsochatzis EA, Guha IN, Garcia-Retortillo M, Morillas RM, Hernández R, Hoyo J, Fuentes M, Madir A, Juanola A, Soria A, Juan M et al. (2023)
Correction: LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries
BMC Public Health, 23 (1), 923
DOI 10.1186/s12889-023-15867-6, PubMed 37217864

Gui W, Hole MJ, Molinaro A, Edlund K, Jørgensen KK, Su H, Begher-Tibbe B, Gaßler N, Schneider CV, Muthukumarasamy U, Mohs A, Liao L, Jaeger J, Mertens CJ, Bergheim I, Strowig T, Hengstler JG, Hov JR, Marschall HU, Trautwein C, Schneider KM (2023)
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
Nat Commun, 14 (1), 3304
DOI 10.1038/s41467-023-38840-8, PubMed 37280200

Han Y, Byun J, Zhu C, Sun R, Roh JY, Cordell HJ, Lee HS, Shaw VR, Kang SW, Razjouyan J, Cooley MA, Hassan MM, Siminovitch KA, Folseraas T, Ellinghaus D, Bergquist A, Rushbrook SM, Franke A, Karlsen TH, Lazaridis KN, International PSC Study Group, McGlynn KA, Roberts LR, Amos CI (2023)
Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis
Nat Commun, 14 (1), 1069
DOI 10.1038/s41467-023-36678-8, PubMed 36828809

Harrison SP, Siller R, Tanaka Y, Chollet ME, de la Morena-Barrio ME, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud KS, Lunov O, Dejneka A, Mowinckel MC, Stavik B, Sandset PM, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson SR, Skottvoll FS et al. (2023)
Scalable production of tissue-like vascularized liver organoids from human PSCs
Exp Mol Med, 55 (9), 2005-2024
DOI 10.1038/s12276-023-01074-1, PubMed 37653039

Haukeland JW, Vesterhus MN, Jørgensen KK, Frigstad SO, Karlsen TH (2023)
[The FIB-4 test as a decision-making tool]
Tidsskr Nor Laegeforen, 143 (5)
DOI 10.4045/tidsskr.23.0176, PubMed 36987901

Helgadottir H, Folseraas T, Kemmerich G, Aabakken L, Jørgensen KK, Vesterhus M (2023)
[Not Available]
Tidsskr Nor Laegeforen, 143 (17)
DOI 10.4045/tidsskr.23.0156, PubMed 37987062

Helgadottir H, Vesterhus M (2023)
Noninvasive evaluation of fibrosis in adult biliary diseases
Curr Opin Gastroenterol, 39 (2), 83-88
DOI 10.1097/MOG.0000000000000909, PubMed 36821455

Hole MJ, Jørgensen KK, Holm K, Braadland PR, Meyer-Myklestad MH, Medhus AW, Reikvam DH, Götz A, Grzyb K, Boberg KM, Karlsen TH, Kummen M, Hov JR (2023)
A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation
Hepatology, 77 (3), 715-728
DOI 10.1002/hep.32773, PubMed 36056902

Hole MJ, Jørgensen KK, Holm K, Braadland PR, Meyer-Myklestad MH, Medhus AW, Reikvam DH, Götz A, Grzyb K, Boberg KM, Karlsen TH, Kummen M, Hov JR (2023)
Reply: The mucosal gut signature in primary sclerosing cholangitis before and after liver transplantation. Is the dysbiosis index really predictive for the recurrence of PSC?
Hepatology, 77 (6), E188-E189
DOI 10.1097/HEP.0000000000000340, PubMed 36815351

Hov JR (2023)
Editorial: dietary interventions to understand and treat primary sclerosing cholangitis-is gluten-free diet a starting point?
Aliment Pharmacol Ther, 57 (2), 265-266
DOI 10.1111/apt.17326, PubMed 36565005

Jiang X, Otterdal K, Chung BK, Maucourant C, Rønneberg JD, Zimmer CL, Øgaard J, Boichuk Y, Holm S, Geanon D, Schneditz G, Bergquist A, Björkström NK, Melum E (2023)
Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation
Gastroenterology, 166 (4), 667-679
DOI 10.1053/j.gastro.2023.11.283, PubMed 37995866

Juul FE, Hov JER, Trøseid M, Johnsen PH, Valeur J (2023)
[Not Available]
Tidsskr Nor Laegeforen, 143 (10)
DOI 10.4045/tidsskr.23.0121, PubMed 37376933

Krag A, Buti M, Lazarus JV, Allen AM, Bowman J, Burra P, Donnini G, Duseja A, El-Sayed MH, Gastaldelli A, Hainsworth B, Karlsen TH, Kessler M, Korenjak M, Mark HE, Mann JP, Miller V, Pessoa MG, Piñeiro D, Sarin SK, Singh SP, Rinella ME, Willemse J, Younossi ZM, Francque SM (2023)
Uniting to defeat steatotic liver disease: A global mission to promote healthy livers and healthy lives
J Hepatol, 79 (5), 1076-1078
DOI 10.1016/j.jhep.2023.07.029, PubMed 37634993

Lapitz A, Azkargorta M, Milkiewicz P, Olaizola P, Zhuravleva E, Grimsrud MM, Schramm C, Arbelaiz A, O'Rourke CJ, La Casta A, Milkiewicz M, Pastor T, Vesterhus M, Jimenez-Agüero R, Dill MT, Lamarca A, Valle JW, Macias RIR, Izquierdo-Sanchez L, Pérez Castaño Y, Caballero-Camino FJ, Riaño I, Krawczyk M, Ibarra C, Bustamante J et al. (2023)
Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma
J Hepatol, 79 (1), 93-108
DOI 10.1016/j.jhep.2023.02.027, PubMed 36868481

Macpherson ME, Skarpengland T, Hov JR, Ranheim T, Vestad B, Dahl TB, Fraz MSA, Michelsen AE, Holven KB, Fevang B, Berge RK, Aukrust P, Halvorsen B, Jørgensen SF (2023)
Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
J Clin Immunol, 43 (6), 1229-1240
DOI 10.1007/s10875-023-01475-x, PubMed 36995502

Mayer C, Nehring S, Kücken M, Repnik U, Seifert S, Sljukic A, Delpierre J, Morales-Navarrete H, Hinz S, Brosch M, Chung B, Karlsen T, Huch M, Kalaidzidis Y, Brusch L, Hampe J, Schafmayer C, Zerial M (2023)
Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease
EMBO Rep, 24 (9), e57181
DOI 10.15252/embr.202357181, PubMed 37522754

Mikaeloff F, Gelpi M, Benfeitas R, Knudsen AD, Vestad B, Høgh J, Hov JR, Benfield T, Murray D, Giske CG, Mardinoglu A, Trøseid M, Nielsen SD, Neogi U (2023)
Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection
Elife, 12
DOI 10.7554/eLife.82785, PubMed 36794912

Nendl A, Raju SC, Broch K, Mayerhofer CCK, Holm K, Halvorsen B, Lappegård KT, Moscavitch S, Hov JR, Seljeflot I, Trøseid M, Awoyemi A (2023)
Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure
Front Cardiovasc Med, 10, 1160030
DOI 10.3389/fcvm.2023.1160030, PubMed 37332580

Oldereid TS, Jiang X, Nordhus KS, Ponzetta A, Bjørnholt JV, Björkström NK, Melum E, Rasmussen H (2023)
Role of bacteria and microbial metabolites in immune modulation during early life
Scand J Immunol, 99 (2), e13336
DOI 10.1111/sji.13336, PubMed 38441196

Schneider KM, Kummen M, Trivedi PJ, Hov JR (2023)
Role of microbiome in autoimmune liver diseases
Hepatology (in press)
DOI 10.1097/HEP.0000000000000506, PubMed 37369002

Serra-Burriel M, Juanola A, Serra-Burriel F, Thiele M, Graupera I, Pose E, Pera G, Grgurevic I, Caballeria L, Piano S, van Kleef L, Reichert M, Roulot D, Pericàs JM, Schattenberg JM, Tsochatztis EA, Guha IN, Garcia-Retortillo M, Hernández R, Hoyo J, Fuentes M, Expósito C, Martínez A, Such P, Madir A et al. (2023)
Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study
Lancet, 402 (10406), 988-996
DOI 10.1016/S0140-6736(23)01174-1, PubMed 37572680

Serrano-Villar S, Tincati C, Raju SC, Sáenz JS, Moreno E, Bargiela R, Cabello-Ubeda A, Sendagorta E, Kurz A, Perez Molina JA, de Benito A, Hov JR, Fernandez-Lopez L, Muriel A, Del Campo R, Moreno S, Trøseid M, Seifert J, Ferrer M (2023)
Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer
Nat Med, 29 (7), 1738-1749
DOI 10.1038/s41591-023-02407-3, PubMed 37464040

Steiert TA, Parra G, Gut M, Arnold N, Trotta JR, Tonda R, Moussy A, Gerber Z, Abuja PM, Zatloukal K, Röcken C, Folseraas T, Grimsrud MM, Vogel A, Goeppert B, Roessler S, Hinz S, Schafmayer C, Rosenstiel P, Deleuze JF, Gut IG, Franke A, Forster M (2023)
A critical spotlight on the paradigms of FFPE-DNA sequencing
Nucleic Acids Res, 51 (14), 7143-7162
DOI 10.1093/nar/gkad519, PubMed 37351572

Tedbury PR, Manfredi C, Degenhardt F, Conway J, Horwath MC, McCracken C, Sorscher AJ, Moreau S, Wright C, Edwards C, Brewer J, Guarner J, de Wit E, Williamson BN, Suthar MS, Ong YT, Roback JD, Alter DN, Holter JC, Karlsen TH, Sacchi N, Romero-Gómez M, Invernizzi P, Fernández J, Buti M et al. (2023)
Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity
FASEB J, 37 (11), e23220
DOI 10.1096/fj.202300077R, PubMed 37801035

Tran TT, Vaage EB, Mehta A, Chopra A, Tietze L, Kolderup A, Anthi A, König M, Nygaard G, Lind A, Müller F, Nissen-Meyer LS, Magnus P, Trogstad L, Mjaaland S, Søraas A, Midtvedt K, Åsberg A, Barratt-Due A, Medhus AW, Høivik ML, Lundin K, Karlsen RF, Dahle R, Danielsson K et al. (2023)
Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 8 (1), 4
DOI 10.1038/s41541-023-00600-6, PubMed 36697432

Trøseid M, Holter JC, Holm K, Vestad B, Sazonova T, Granerud BK, Dyrhol-Riise AM, Holten AR, Tonby K, Kildal AB, Heggelund L, Tveita A, Bøe S, Müller KE, Jenum S, Hov JR, Ueland T, Norwegian SARS-CoV-2 study group (2023)
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
Crit Care, 27 (1), 69
DOI 10.1186/s13054-023-04356-2, PubMed 36814280

Wacker EM, Uellendahl-Werth F, Bej S, Wolkenhauer O, Vesterhus M, Lieb W, Franke A, Karlsen TH, Folseraas T, Ellinghaus D (2023)
Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis
JHEP Rep, 6 (2), 100988
DOI 10.1016/j.jhepr.2023.100988, PubMed 38304234

Yaqub S, Bjørk I, Sugulle M, Folseraas T (2023)
Biopsy helpful in diagnosing a liver mass in pregnancy: focal nodular hyperplasia
Lancet, 402 (10403), e10
DOI 10.1016/S0140-6736(23)01606-9, PubMed 37633669

Publications 2022

Awoniyi M, Wang J, Ngo B, Meadows V, Tam J, Viswanathan A, Lai Y, Montgomery S, Farmer M, Kummen M, Thingholm L, Schramm C, Bang C, Franke A, Lu K, Zhou H, Bajaj JS, Hylemon PB, Ting J, Popov YV, Hov JR, Francis HL, Sartor RB (2022)
Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC
Gut, 72 (4), 671-685
DOI 10.1136/gutjnl-2021-326500, PubMed 35705368

Awoyemi A, Hov JR, Trøseid M (2022)
Phenylacetylglutamine From the Gut Microbiota: A Future Therapeutic Target in Heart Failure?
Circ Heart Fail, 16 (1), e010222
DOI 10.1161/CIRCHEARTFAILURE.122.010222, PubMed 36524473

Bergquist A, Weismüller TJ, Levy C, Rupp C, Joshi D, Nayagam JS, Montano-Loza AJ, Lytvyak E, Wunsch E, Milkiewicz P, Zenouzi R, Schramm C, Cazzagon N, Floreani A, Liby IF, Wiestler M, Wedemeyer H, Zhou T, Strassburg CP, Rigopoulou E, Dalekos G, Narasimman M, Verhelst X, Degroote H, Vesterhus M et al. (2022)
Impact on follow-up strategies in patients with primary sclerosing cholangitis
Liver Int, 43 (1), 127-138
DOI 10.1111/liv.15286, PubMed 35535655

Botteri E, Hoff G, Randel KR, Holme Ø, de Lange T, Bernklev T, Aas E, Berthelsen M, Natvig E, Kirkøen B, Knudsen MD, Kvaerner AS, Schult AL, Ursin G, Jørgensen A, Berstad P (2022)
Characteristics of nonparticipants in a randomised colorectal cancer screening trial comparing sigmoidoscopy and faecal immunochemical testing
Int J Cancer, 151 (3), 361-371
DOI 10.1002/ijc.34025, PubMed 35411554

Brevini T, Maes M, Webb GJ, John BV, Fuchs CD, Buescher G, Wang L, Griffiths C, Brown ML, Scott WE, Pereyra-Gerber P, Gelson WTH, Brown S, Dillon S, Muraro D, Sharp J, Neary M, Box H, Tatham L, Stewart J, Curley P, Pertinez H, Forrest S, Mlcochova P, Varankar SS et al. (2022)
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Nature, 615 (7950), 134-142
DOI 10.1038/s41586-022-05594-0, PubMed 36470304

Braadland PR, Schneider KM, Bergquist A, Molinaro A, Lövgren-Sandblom A, Henricsson M, Karlsen TH, Vesterhus M, Trautwein C, Hov JR, Marschall HU (2022)
Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis
JHEP Rep, 4 (11), 100561
DOI 10.1016/j.jhepr.2022.100561, PubMed 36176935

Chung BK, Øgaard J, Reims HM, Karlsen TH, Melum E (2022)
Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis
Hepatol Commun, 6 (9), 2538-2550
DOI 10.1002/hep4.2001, PubMed 35726350

Cruz R, Diz-de Almeida S, López de Heredia M, Quintela I, Ceballos FC, Pita G, Lorenzo-Salazar JM, González-Montelongo R, Gago-Domínguez M, Sevilla Porras M, Tenorio Castaño JA, Nevado J, Aguado JM, Aguilar C, Aguilera-Albesa S, Almadana V, Almoguera B, Alvarez N, Andreu-Bernabeu Á, Arana-Arri E, Arango C, Arranz MJ, Artiga MJ, Baptista-Rosas RC, Barreda-Sánchez M et al. (2022)
Novel genes and sex differences in COVID-19 severity
Hum Mol Genet, 31 (22), 3789-3806
DOI 10.1093/hmg/ddac132, PubMed 35708486

Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Blandino Ortiz A, de Salazar A, Garrido Chercoles A, Palom A, Ruiz A, Garcia-Fernandez AE, Blanco-Grau A, Mantovani A, Zanella A et al. (2022)
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Hum Mol Genet, 31 (23), 3945-3966
DOI 10.1093/hmg/ddac158, PubMed 35848942

Eliasson J, Lo B, Schramm C, Chazouilleres O, Folseraas T, Beuers U, Ytting H (2022)
Survey uncovering variations in the management of primary sclerosing cholangitis across Europe
JHEP Rep, 4 (11), 100553
DOI 10.1016/j.jhepr.2022.100553, PubMed 36164416

Gelpi M, Vestad B, Raju SC, Hansen SH, Høgh J, Midttun Ø, Ueland PM, Ueland T, Benfield T, Kofoed KF, Hov JR, Trøseid M, Nielsen SD (2022)
Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation
J Infect Dis, 225 (11), 1948-1954
DOI 10.1093/infdis/jiac018, PubMed 35089326

Graupera I, Thiele M, Ma AT, Serra-Burriel M, Pich J, Fabrellas N, Caballeria L, de Knegt RJ, Grgurevic I, Reichert M, Roulot D, Schattenberg JM, Pericas JM, Angeli P, Tsochatzis EA, Guha IN, Garcia-Retortillo M, Morillas RM, Hernández R, Hoyo J, Fuentes M, Madir A, Juanola A, Soria A, Juan M et al. (2022)
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries
BMC Public Health, 22 (1), 1385
DOI 10.1186/s12889-022-13724-6, PubMed 35854275

He MM, Lo CH, Wang K, Polychronidis G, Wang L, Zhong R, Knudsen MD, Fang Z, Song M (2022)
Immune-Mediated Diseases Associated With Cancer Risks
JAMA Oncol, 8 (2), 209-219
DOI 10.1001/jamaoncol.2021.5680, PubMed 34854871

Helgadottir H, Folvik G, Vesterhus M (2022)
Improvement of cholestatic episodes in patients with benign recurrent intrahepatic cholestasis (BRIC) treated with rifampicin. A long-term follow-up
Scand J Gastroenterol, 58 (5), 512-520
DOI 10.1080/00365521.2022.2143725, PubMed 36369734

Hov JR, Karlsen TH (2022)
The microbiota and the gut-liver axis in primary sclerosing cholangitis
Nat Rev Gastroenterol Hepatol, 20 (3), 135-154
DOI 10.1038/s41575-022-00690-y, PubMed 36352157

Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł et al. (2022)
Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry
J Hepatol, 76 (5), 1109-1121
DOI 10.1016/j.jhep.2021.12.010, PubMed 35167909

Karlsen TH (2022)
Understanding COVID-19 through genome-wide association studies
Nat Genet, 54 (4), 368-369
DOI 10.1038/s41588-021-00985-x, PubMed 35410380

Knudsen MD, Kvaerner AS, Botteri E, Holme Ø, Hjartåker A, Song M, Thiis-Evensen E, Randel KR, Hoff G, Berstad P (2022)
Lifestyle predictors for inconsistent participation to fecal based colorectal cancer screening
BMC Cancer, 22 (1), 172
DOI 10.1186/s12885-022-09287-9, PubMed 35168592

Krag A, Karlsen TH (2022)
[Not Available]
Ugeskr Laeger, 184 (8)
PubMed 35244013

Kaarbø M, Yang M, Hov JR, Holm K, de Sousa MML, Macpherson ME, Reims HM, Kran AB, Halvorsen B, Karlsen TH, Aukrust P, Lundin KEA, Fevang B, Bjørås M, Jørgensen SF (2022)
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses
J Allergy Clin Immunol, 151 (3), 767-777
DOI 10.1016/j.jaci.2022.09.029, PubMed 36220400

Laursen TL, Bossen L, Pihl R, Troldborg A, Sandahl TD, Hansen AG, Folserass T, Vesterhus M, Grønbæk H, Thiel S (2022)
Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases
J Clin Transl Hepatol, 10 (5), 796-802
DOI 10.14218/JCTH.2021.00515, PubMed 36304505

Lei L, Bruneau A, El Mourabit H, Guégan J, Folseraas T, Lemoinne S, Karlsen TH, Hoareau B, Morichon R, Gonzalez-Sanchez E, Goumard C, Ratziu V, Charbord P, Gautheron J, Tacke F, Jaffredo T, Cadoret A, Housset C (2022)
Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis
Hepatology, 76 (5), 1360-1375
DOI 10.1002/hep.32456, PubMed 35278227

Meyer-Myklestad MH, Medhus AW, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Stiksrud B, Trøseid M, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Reikvam DH (2022)
Human Immunodeficiency Virus-Infected Immunological Nonresponders Have Colon-Restricted Gut Mucosal Immune Dysfunction
J Infect Dis, 225 (4), 661-674
DOI 10.1093/infdis/jiaa714, PubMed 33216130

Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Trøseid M, Reikvam DH (2022)
Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum
J Acquir Immune Defic Syndr, 89 (1), 77-86
DOI 10.1097/QAI.0000000000002817, PubMed 34878437

Nooijen LE, Banales JM, de Boer MT, Braconi C, Folseraas T, Forner A, Holowko W, Hoogwater FJH, Klümpen HJ, Groot Koerkamp B, Lamarca A, La Casta A, López-López F, Izquierdo-Sánchez L, Scheiter A, Utpatel K, Swijnenburg RJ, Kazemier G, Erdmann JI,   ENSCCA Group (2022)
Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry
Cancers (Basel), 14 (10)
DOI 10.3390/cancers14102389, PubMed 35625993

Singh Y, Jons WA, Eaton JE, Vesterhus M, Karlsen T, Bjoerk I, Abildgaard A, Jorgensen KK, Folseraas T, Little D, Gulamhusein AF, Petrovic K, Negard A, Conte GM, Sobek JD, Jagtap J, Venkatesh SK, Gores GJ, LaRusso NF, Lazaridis KN, Erickson BJ (2022)
Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis
Eur Radiol Exp, 6 (1), 58
DOI 10.1186/s41747-022-00312-x, PubMed 36396865

Storm-Larsen C, Hande LN, Kummen M, Thunhaug H, Vestad B, Hansen SH, Hovland A, Trøseid M, Lappegård KT, Hov JR (2022)
Reduced gut microbial diversity in familial hypercholesterolemia with no effect of omega-3 polyunsaturated fatty acids intervention - a pilot trial
Scand J Clin Lab Invest, 82 (5), 363-370
DOI 10.1080/00365513.2022.2102540, PubMed 35913798

Stø K, Valeur J, Ueland T, Malmstrøm GH, Bjerkeli V, Trøseid M, Hov JR, Holm K, Vestad B, Halvorsen B, Skjelland M, Skagen KR (2022)
Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis
Sci Rep, 12 (1), 22378
DOI 10.1038/s41598-022-26759-x, PubMed 36572703

Tran TT, Vaage EB, Mehta A, Chopra A, Tietze L, Kolderup A, Anthi A, König M, Nygaard G, Lind A, Müller F, Nissen-Meyer LS, Magnus P, Trogstad L, Mjaaland S, Søraas A, Midtvedt K, Åsberg A, Barratt-Due A, Medhus AW, Høivik ML, Lundin K, Karlsen RF, Dahle R, Danielsson K et al. (2022)
Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 7 (1), 174
DOI 10.1038/s41541-022-00586-7, PubMed 36585405

Tønnessen TC, Melleby AO, Hauge-Iversen IM, Espe EKS, Ahmed MS, Ueland T, Haavardsholm EA, Atkinson SM, Melum E, Attramadal H, Sjaastad I, Vinge LE (2022)
Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice
PLoS One, 17 (1), e0262821
DOI 10.1371/journal.pone.0262821, PubMed 35077491

Valestrand L, Zheng F, Hansen SH, Øgaard J, Hov JR, Björkström NK, Karlsen TH, Jiang X, Melum E (2022)
Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens
Am J Pathol, 192 (4), 629-641
DOI 10.1016/j.ajpath.2021.12.008, PubMed 35063408

van der Meer D, Gurholt TP, Sønderby IE, Shadrin AA, Hindley G, Rahman Z, de Lange AG, Frei O, Leinhard OD, Linge J, Simon R, Beck D, Westlye LT, Halvorsen S, Dale AM, Karlsen TH, Kaufmann T, Andreassen OA (2022)
The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition
Commun Biol, 5 (1), 1271
DOI 10.1038/s42003-022-04237-4, PubMed 36402844

Vestad B, Ueland T, Lerum TV, Dahl TB, Holm K, Barratt-Due A, Kåsine T, Dyrhol-Riise AM, Stiksrud B, Tonby K, Hoel H, Olsen IC, Henriksen KN, Tveita A, Manotheepan R, Haugli M, Eiken R, Berg Å, Halvorsen B, Lekva T, Ranheim T, Michelsen AE, Kildal AB, Johannessen A, Thoresen L et al. (2022)
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations
J Intern Med, 291 (6), 801-812
DOI 10.1111/joim.13458, PubMed 35212063

Vesterhus M (2022)
[Good TIPS for severe liver disease]
Tidsskr Nor Laegeforen, 142 (14)
DOI 10.4045/tidsskr.22.0585, PubMed 36226424

Vesterhus M, Jørgensen KK, Frigstad SO, Haukeland JW, Karlsen TH (2022)
[We need a new strategy for liver disease]
Tidsskr Nor Laegeforen, 142 (3)
DOI 10.4045/tidsskr.21.0892, PubMed 35170917

Wang K, Ma W, Hu Y, Knudsen MD, Nguyen LH, Wu K, Ng K, Wang M, Ogino S, Sun Q, Giovannucci EL, Chan AT, Song M (2022)
Endoscopic Screening and Risk of Colorectal Cancer according to Type 2 Diabetes Status
Cancer Prev Res (Phila), 15 (12), 847-856
DOI 10.1158/1940-6207.CAPR-22-0305, PubMed 36049216

Wang L, Knudsen MD, Lo CH, Wang K, He M, Polychronidis G, Hang D, He X, Zhong R, Wu K, Chan AT, Ogino S, Giovannucci EL, Song M (2022)
Adherence to a healthy lifestyle in relation to colorectal cancer incidence and all-cause mortality after endoscopic polypectomy: A prospective study in three U.S. cohorts
Int J Cancer, 151 (9), 1523-1534
DOI 10.1002/ijc.34176, PubMed 35716133

Yu J, Refsum E, Helsingen LM, Folseraas T, Ploner A, Wieszczy P, Barua I, Jodal HC, Melum E, Løberg M, Blom J, Bretthauer M, Adami HO, Kalager M, Ye W (2022)
Risk of hepato-pancreato-biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population-based cohort study
United European Gastroenterol J, 10 (2), 212-224
DOI 10.1002/ueg2.12204, PubMed 35107865

Publications 2021

Aune D, Sen A, Norat T, Riboli E, Folseraas T (2021)
Primary sclerosing cholangitis and the risk of cancer, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of cohort studies
Sci Rep, 11 (1), 10646
DOI 10.1038/s41598-021-90175-w, PubMed 34017024

Awoyemi A, Mayerhofer C, Felix AS, Hov JR, Moscavitch SD, Lappegård KT, Hovland A, Halvorsen S, Halvorsen B, Gregersen I, Svardal A, Berge RK, Hansen SH, Götz A, Holm K, Aukrust P, Åkra S, Seljeflot I, Solheim S, Lorenzo A, Gullestad L, Trøseid M, Broch K (2021)
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
EBioMedicine, 70, 103511
DOI 10.1016/j.ebiom.2021.103511, PubMed 34329947

Bossen L, Vesterhus M, Hov JR, Färkkilä M, Rosenberg WM, Møller HJ, Boberg KM, Karlsen TH, Grønbæk H (2021)
Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis
Clin Transl Gastroenterol, 12 (3), e00315
DOI 10.14309/ctg.0000000000000315, PubMed 33646203

COVID-19 Host Genetics Initiative (2021)
Mapping the human genetic architecture of COVID-19
Nature, 600 (7889), 472-477
DOI 10.1038/s41586-021-03767-x, PubMed 34237774

Degenhardt F, Mayr G, Wendorff M, Boucher G, Ellinghaus E, Ellinghaus D, ElAbd H, Rosati E, Hübenthal M, Juzenas S, Abedian S, Vahedi H, Thelma BK, Yang SK, Ye BD, Cheon JH, Datta LW, Daryani NE, Ellul P, Esaki M, Fuyuno Y, McGovern DPB, Haritunians T, Hong M, Juyal G et al. (2021)
Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations
Hum Mol Genet, 30 (5), 356-369
DOI 10.1093/hmg/ddab017, PubMed 33555323

Dhillon AK, Rupp C, Bergquist A, Voitl R, Folseraas T, Trøseid M, Midttun Ø, Ueland PM, Karlsen TH, Vesterhus M, Kummen M, Hov JR (2021)
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand J Gastroenterol, 56 (4), 443-452
DOI 10.1080/00365521.2021.1880627, PubMed 33583308

Fossdal G, Mjelle AB, Wiencke K, Bjørk I, Gilja OH, Folseraas T, Karlsen TH, Rosenberg W, Giil LM, Vesterhus M (2021)
Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF
JHEP Rep, 3 (5), 100328
DOI 10.1016/j.jhepr.2021.100328, PubMed 34485881

Hausken J, Haugaa H, Hagness M, Line PD, Melum E, Tønnessen TI (2021)
Thoracic Epidural Analgesia for Postoperative Pain Management in Liver Transplantation: A 10-year Study on 685 Liver Transplant Recipients
Transplant Direct, 7 (2), e648
DOI 10.1097/TXD.0000000000001101, PubMed 33437863

Jiang X, Bergquist A, Löscher BS, Venkatesh G, Mold JE, Holm K, Laerdahl JK, Skånland SS, Maleki KT, Cornillet M, Taskén K, Franke A, Karlsen TH, Björkström NK, Melum E (2021)
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483

Jiang X, Melum E (2021)
The Role of Natural Killer Cells in Nonalcoholic Steatohepatitis: An Ongoing Debate
Cell Mol Gastroenterol Hepatol, 13 (1), 348-349
DOI 10.1016/j.jcmgh.2021.10.006, PubMed 34740615

Karlsen TH, Sheron N, Zelber-Sagi S, Carrieri P, Dusheiko G, Bugianesi E, Pryke R, Hutchinson SJ, Sangro B, Martin NK, Cecchini M, Dirac MA, Belloni A, Serra-Burriel M, Ponsioen CY, Sheena B, Lerouge A, Devaux M, Scott N, Hellard M, Verkade HJ, Sturm E, Marchesini G, Yki-Järvinen H, Byrne CD et al. (2021)
The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality
Lancet, 399 (10319), 61-116
DOI 10.1016/S0140-6736(21)01701-3, PubMed 34863359

Karlsen TR, Kong XY, Holm S, Quiles-Jiménez A, Dahl TB, Yang K, Sagen EL, Skarpengland T, S Øgaard JD, Holm K, Vestad B, Olsen MB, Aukrust P, Bjørås M, Hov JR, Halvorsen B, Gregersen I (2021)
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
Sci Rep, 11 (1), 19749
DOI 10.1038/s41598-021-98820-0, PubMed 34611194

Knudsen MD, Wang L, Wang K, Wu K, Ogino S, Chan AT, Giovannucci E, Song M (2021)
Changes in Lifestyle Factors After Endoscopic Screening: A Prospective Study in the United States
Clin Gastroenterol Hepatol, 20 (6), e1240-e1249
DOI 10.1016/j.cgh.2021.07.014, PubMed 34256146

Lamarca A, Santos-Laso A, Utpatel K, La Casta A, Stock S, Forner A, Adeva J, Folseraas T, Fabris L, Macias RIR, Krawczyk M, Krawczyk M, Cardinale V, Braconi C, Alvaro D, Evert M, Banales JM, Valle JW (2021)
REPLY
Hepatology, 74 (2), 1129-1131
DOI 10.1002/hep.31740, PubMed 33550618

Lamarca A, Santos-Laso A, Utpatel K, La Casta A, Stock S, Forner A, Adeva J, Folseraas T, Fabris L, Macias RIR, Krawczyk M, Krawczyk M, Cardinale V, Braconi C, Alvaro D, Evert M, Banales JM, Valle JW (2021)
Letter to the Editor: Does Multiple Intrahepatic Cholangiocarcinoma Worsen Prognosis as "M1" Stage? REPLY
Hepatology, 74 (2), 1129-1131
DOI 10.1002/hep.31740

Lamarca A, Santos-Laso A, Utpatel K, La Casta A, Stock S, Forner A, Adeva J, Folseraas T, Fabris L, Macias RIR, Krawczyk M, Krawczyk M, Cardinale V, Braconi C, Alvaro D, Evert M, Banales JM, Valle JW, Group: on behalf of the European Network for the Study of Cholangiocarcinoma (ENS-CCA) (2021)
Liver Metastases of Intrahepatic Cholangiocarcinoma: Implications for an Updated Staging System
Hepatology, 73 (6), 2311-2325
DOI 10.1002/hep.31598, PubMed 33073396

Lissing M, Nowak G, Adam R, Karam V, Boyd A, Gouya L, Meersseman W, Melum E, Ołdakowska-Jedynak U, Reiter FP, Colmenero J, Sanchez R, Herden U, Langendonk J, Ventura P, Isoniemi H, Boillot O, Braun F, Perrodin S, Mowlem E, Wahlin S, European Liver and Intestine Transplant Association (2021)
Liver Transplantation for Acute Intermittent Porphyria
Liver Transpl, 27 (4), 491-501
DOI 10.1002/lt.25959, PubMed 33259654

Mousa OY, Juran BD, McCauley BM, Vesterhus MN, Folseraas T, Turgeon CT, Ali AH, Schlicht EM, Atkinson EJ, Hu C, Harnois D, Carey EJ, Gossard AA, Oglesbee D, Eaton JE, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN (2021)
Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation
Hepatology, 74 (1), 281-295
DOI 10.1002/hep.31652, PubMed 33226645

Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Bujanda L, Bouysran Y, Niemi ME, Palom A, Ellinghaus D, Khan A, Martínez-Bueno M, Rolker S, Amitrano S, Roade Tato L, Fava F, FinnGen, COVID-19 Host Genetics Initiative (HGI), Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernández-Cadenas I et al. (2021)
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
J Clin Invest, 131 (23)
DOI 10.1172/JCI152386, PubMed 34597274

Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Nafría-Jiménez B, Bouysran Y, Niemi M, Palom A, Ellinghaus D, Khan A, Martínez-Bueno M, Rolker S, Amitano S, Tato LR, FinnGen, The COVID-19 Host Genetics Initiative, Fava F, Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernández-Cadenas I, Holter JC et al. (2021)
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
medRxiv
DOI 10.1101/2021.03.07.21252875, PubMed 33758887

Pagano E, Elias JE, Schneditz G, Saveljeva S, Holland LM, Borrelli F, Karlsen TH, Kaser A, Kaneider NC (2021)
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment
Gut, 71 (3), 509-520
DOI 10.1136/gutjnl-2020-323363, PubMed 33758004

Polychronidis G, Wang K, Lo CH, Wang L, He M, Knudsen MD, Wu K, Joshi AD, Ogino S, Giovannucci EL, Chan AT, Song M (2021)
Gallstone Disease and Risk of Conventional Adenomas and Serrated Polyps: A Prospective Study
Cancer Epidemiol Biomarkers Prev, 30 (12), 2346-2349
DOI 10.1158/1055-9965.EPI-21-0515, PubMed 34620626

Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Höhne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, García-Beccaria M, Gabernet G, Nahnsen S, Mallm JP et al. (2021)
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
J Hepatol, 75 (3), 634-646
DOI 10.1016/j.jhep.2021.03.029, PubMed 33872692

Sampaziotis F, Muraro D, Tysoe OC, Sawiak S, Beach TE, Godfrey EM, Upponi SS, Brevini T, Wesley BT, Garcia-Bernardo J, Mahbubani K, Canu G, Gieseck R, Berntsen NL, Mulcahy VL, Crick K, Fear C, Robinson S, Swift L, Gambardella L, Bargehr J, Ortmann D, Brown SE, Osnato A, Murphy MP et al. (2021)
Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Science, 371 (6531), 839-846
DOI 10.1126/science.aaz6964, PubMed 33602855

Schneider KM, Candels LS, Hov JR, Myllys M, Hassan R, Schneider CV, Wahlström A, Mohs A, Zühlke S, Liao L, Elfers C, Kilic K, Henricsson M, Molinaro A, Hatting M, Zaza A, Drasdo D, Frissen M, Devlin AS, Gálvez EJC, Strowig T, Karlsen TH, Hengstler JG, Marschall HU, Ghallab A et al. (2021)
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
Nat Metab, 3 (9), 1228-1241
DOI 10.1038/s42255-021-00452-1, PubMed 34552267

Skarpengland T, Macpherson ME, Hov JR, Kong XY, Bohov P, Halvorsen B, Fevang B, Berge RK, Aukrust P, Jørgensen SF (2021)
Altered Plasma Fatty Acids Associate with Gut Microbial Composition in Common Variable Immunodeficiency
J Clin Immunol, 42 (1), 146-157
DOI 10.1007/s10875-021-01146-9, PubMed 34669143

Skaarud KJ, Hov JR, Hansen SH, Kummen M, Valeur J, Seljeflot I, Bye A, Paulsen V, Lundin KEA, Trøseid M, Tjønnfjord GE, Iversen PO (2021)
Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
Sci Rep, 11 (1), 11593
DOI 10.1038/s41598-021-90976-z, PubMed 34078971

Vedeld HM, Grimsrud MM, Andresen K, Pharo HD, von Seth E, Karlsen TH, Honne H, Paulsen V, Färkkilä MA, Bergquist A, Jeanmougin M, Aabakken L, Boberg KM, Folseraas T, Lind GE (2021)
Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile
Hepatology, 75 (1), 59-73
DOI 10.1002/hep.32125, PubMed 34435693

Vestad B, Nyman TA, Hove-Skovsgaard M, Stensland M, Hoel H, Trøseid AS, Aspelin T, Aass HCD, Puhka M, Hov JR, Nielsen SD, Øvstebø R, Trøseid M (2021)
Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk
Sci Rep, 11 (1), 21936
DOI 10.1038/s41598-021-01334-y, PubMed 34754007

Vesterhus M, Wiencke K, Haukeland JW, Frigstad SO, Karlsen LN, Jørgensen KK, Folseraas T (2021)
[Diagnosis and treatment of autoimmune hepatitis]
Tidsskr Nor Laegeforen, 141 (10)
DOI 10.4045/tidsskr.20.1045, PubMed 34182737

Zimmer CL, Filipovic I, Cornillet M, O'Rourke CJ, Berglin L, Jansson H, Sun D, Strauss O, Hertwig L, Johansson H, von Seth E, Sparrelid E, Dias J, Glaumann H, Melum E, Ellis EC, Sandberg JK, Andersen JB, Bergquist A, Björkström NK (2021)
Mucosal-associated invariant T-cell tumor infiltration predicts long-term survival in cholangiocarcinoma
Hepatology, 75 (5), 1154-1168
DOI 10.1002/hep.32222, PubMed 34719787

Zimmer CL, von Seth E, Buggert M, Strauss O, Hertwig L, Nguyen S, Wong AYW, Zotter C, Berglin L, Michaëlsson J, Hansson MR, Arnelo U, Sparrelid E, Ellis ECS, Söderholm JD, Keita ÅV, Holm K, Özenci V, Hov JR, Mold JE, Cornillet M, Ponzetta A, Bergquist A, Björkström NK (2021)
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Sci Transl Med, 13 (599)
DOI 10.1126/scitranslmed.abb3107, PubMed 34162753

Publications 2020

Deeb M, Karlsen TH, Hirschfield GM (2020)
The 6 C's of primary sclerosing cholangitis
J Hepatol, 73 (5), 1255-1256
DOI 10.1016/j.jhep.2020.06.033, PubMed 32649970

Derer S, Brethack AK, Pietsch C, Jendrek ST, Nitzsche T, Bokemeyer A, Hov JR, Schäffler H, Bettenworth D, Grassl GA, Sina C (2020)
Inflammatory Bowel Disease-associated GP2 Autoantibodies Inhibit Mucosal Immune Response to Adherent-invasive Bacteria
Inflamm Bowel Dis, 26 (12), 1856-1868
DOI 10.1093/ibd/izaa069, PubMed 32304568

Fretheim H, Chung BK, Didriksen H, Bækkevold ES, Midtvedt Ø, Brunborg C, Holm K, Valeur J, Tennøe AH, Garen T, Midtvedt T, Trøseid M, Zarè H, Lund MB, Hov JR, Lundin KEA, Molberg Ø, Hoffmann-Vold AM (2020)
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393

Gelpi M, Vestad B, Hansen SH, Holm K, Drivsholm N, Goetz A, Kirkby NS, Lindegaard B, Lebech AM, Hoel H, Michelsen AE, Ueland T, Gerstoft J, Lundgren J, Hov JR, Nielsen SD, Trøseid M (2020)
Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions
Clin Infect Dis, 71 (8), e359-e367
DOI 10.1093/cid/ciz1235, PubMed 31894240

Goeppert B, Folseraas T, Roessler S, Kloor M, Volckmar AL, Endris V, Buchhalter I, Stenzinger A, Grzyb K, Grimsrud MM, Gornicka B, von Seth E, Reynolds GM, Franke A, Gotthardt DN, Mehrabi A, Cheung A, Verheij J, Arola J, Mäkisalo H, Eide TJ, Weidemann S, Cheville JC, Mazza G, Hirschfield GM et al. (2020)
Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities
Hepatology, 72 (4), 1253-1266
DOI 10.1002/hep.31110, PubMed 31925805

He MM, Fang Z, Hang D, Wang F, Polychronidis G, Wang L, Lo CH, Wang K, Zhong R, Knudsen MD, Smith SG, Xu RH, Song M (2020)
Circulating liver function markers and colorectal cancer risk: A prospective cohort study in the UK Biobank
Int J Cancer, 148 (8), 1867-1878
DOI 10.1002/ijc.33351, PubMed 33091956

Knudsen MD, Botteri E, Holme Ø, Hjartåker A, Song M, Thiis-Evensen E, Norvard ER, Schult AL, Randel KR, Hoff G, Berstad P (2020)
Association between lifestyle and site-specific advanced colorectal lesions in screening with faecal immunochemical test and sigmoidoscopy
Dig Liver Dis, 53 (3), 353-359
DOI 10.1016/j.dld.2020.11.021, PubMed 33309513

Kovaleva TF, Maksimova NS, Pchelin PV, Pershin VI, Tkachenko NM, Gainullin MR, Mukhina IV (2020)
A New Cofilin-Dependent Mechanism for the Regulation of Brain Mitochondria Biogenesis and Degradation
Sovrem Tekhnologii Med, 12 (1), 6-13
DOI 10.17691/stm2020.12.1.01, PubMed 34513032

Kummen M, Solberg OG, Storm-Larsen C, Holm K, Ragnarsson A, Trøseid M, Vestad B, Skårdal R, Yndestad A, Ueland T, Svardal A, Berge RK, Seljeflot I, Gullestad L, Karlsen TH, Aaberge L, Aukrust P, Hov JR (2020)
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y, PubMed 32214138

Kummen M, Thingholm LB, Rühlemann MC, Holm K, Hansen SH, Moitinho-Silva L, Liwinski T, Zenouzi R, Storm-Larsen C, Midttun Ø, McCann A, Ueland PM, Høivik ML, Vesterhus M, Trøseid M, Laudes M, Lieb W, Karlsen TH, Bang C, Schramm C, Franke A, Hov JR (2020)
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Gastroenterology, 160 (5), 1784-1798.e0
DOI 10.1053/j.gastro.2020.12.058, PubMed 33387530

Lapitz A, Arbelaiz A, O'Rourke CJ, Lavin JL, Casta A, Ibarra C, Jimeno JP, Santos-Laso A, Izquierdo-Sanchez L, Krawczyk M, Perugorria MJ, Jimenez-Aguero R, Sanchez-Campos A, Riaño I, Gónzalez E, Lammert F, Marzioni M, Macias RIR, Marin JJG, Karlsen TH, Bujanda L, Falcón-Pérez JM, Andersen JB, Aransay AM, Rodrigues PM et al. (2020)
Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis
Cells, 9 (3)
DOI 10.3390/cells9030721, PubMed 32183400

Lo CH, Kwon S, Wang L, Polychronidis G, Knudsen MD, Zhong R, Cao Y, Wu K, Ogino S, Giovannucci EL, Chan AT, Song M (2020)
Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study
Gut, 70 (3), 620-621
DOI 10.1136/gutjnl-2020-321949, PubMed 32690603

Lohse AW, Sebode M, Jørgensen MH, Ytting H, Karlsen TH, Kelly D, Manns MP, Vesterhus M, European Reference Network on Hepatological Diseases (ERN RARE-LIVER), International Autoimmune Hepatitis Group (IAIHG) (2020)
Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group
J Hepatol, 73 (6), 1496-1506
DOI 10.1016/j.jhep.2020.07.023, PubMed 32707224

Lohse AW, Sebode M, Vesterhus M (2020)
Reply to: "Both tacrolimus and mycophenylate mophetil should be considered second-line therapy for autoimmune hepatitis"
J Hepatol, 74 (3), 755-756
DOI 10.1016/j.jhep.2020.11.031, PubMed 33309116

Louwe MC, Olsen MB, Kaasbøll OJ, Yang K, Fosshaug LE, Alfsnes K, Øgaard JDS, Rashidi A, Skulberg VM, Yang M, de Miranda Fonseca D, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjørås M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377

Macpherson ME, Hov JR, Ueland T, Dahl TB, Kummen M, Otterdal K, Holm K, Berge RK, Mollnes TE, Trøseid M, Halvorsen B, Aukrust P, Fevang B, Jørgensen SF (2020)
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155

Mayerhofer CCK, Kummen M, Holm K, Broch K, Awoyemi A, Vestad B, Storm-Larsen C, Seljeflot I, Ueland T, Bohov P, Berge RK, Svardal A, Gullestad L, Yndestad A, Aukrust P, Hov JR, Trøseid M (2020)
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail, 7 (2), 456-466
DOI 10.1002/ehf2.12596, PubMed 31978943

Mjelle AB, Fossdal G, Gilja OH, Vesterhus M (2020)
Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems
Ultrasound Med Biol, 46 (8), 1854-1864
DOI 10.1016/j.ultrasmedbio.2020.03.025, PubMed 32507342

Severe Covid-19 GWAS Group, Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE et al. (2020)
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N Engl J Med, 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283, PubMed 32558485

Sokolova M, Yang K, Hansen SH, Louwe MC, Kummen M, Hov JER, Sjaastad I, Berge RK, Halvorsen B, Aukrust P, Yndestad A, Ranheim T (2020)
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1, PubMed 33273482

Taraldsen V, Tomasgard S, Rudlang M, Gilja O, Vesterhus M, Mjelle A (2020)
Point Shear Wave Elastography and the Effect of Physical Exercise, Alcohol Consumption, and Respiration in Healthy Adults
Ultrasound Int Open, 6 (3), E54-E61
DOI 10.1055/a-1298-9642, PubMed 33305164

Taraldsen V, Tomasgard S, Rudlang MT, Gilja OH, Vesterhus M, Mjelle AB (2020)
Correction: Point Shear Wave Elastography and the Effect of Physical Exercise, Alcohol Consumption, and Respiration in Healthy Adults
Ultrasound Int Open, 6 (3), E66
DOI 10.1055/a-1340-1260, PubMed 33426423

Thaventhiran JED, Lango Allen H, Burren OS, Rae W, Greene D, Staples E, Zhang Z, Farmery JHR, Simeoni I, Rivers E, Maimaris J, Penkett CJ, Stephens J, Deevi SVV, Sanchis-Juan A, Gleadall NS, Thomas MJ, Sargur RB, Gordins P, Baxendale HE, Brown M, Tuijnenburg P, Worth A, Hanson S, Linger RJ et al. (2020)
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Nature, 583 (7814), 90-95
DOI 10.1038/s41586-020-2265-1, PubMed 32499645

Thaventhiran JED, Lango Allen H, Burren OS, Rae W, Greene D, Staples E, Zhang Z, Farmery JHR, Simeoni I, Rivers E, Maimaris J, Penkett CJ, Stephens J, Deevi SVV, Sanchis-Juan A, Gleadall NS, Thomas MJ, Sargur RB, Gordins P, Baxendale HE, Brown M, Tuijnenburg P, Worth A, Hanson S, Linger RJ et al. (2020)
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Nature, 584 (7819), E2
DOI 10.1038/s41586-020-2556-6, PubMed 32678341

Trimboli P, Castellana M, Virili C, Havre RF, Bini F, Marinozzi F, D'Ambrosio F, Giorgino F, Giovanella L, Prosch H, Grani G, Radzina M, Cantisani V (2020)
Performance of contrast-enhanced ultrasound (CEUS) in assessing thyroid nodules: a systematic review and meta-analysis using histological standard of reference
Radiol Med, 125 (4), 406-415
DOI 10.1007/s11547-019-01129-2, PubMed 31970579

Valestrand L, Berntsen NL, Zheng F, Schrumpf E, Hansen SH, Karlsen TH, Blumberg RS, Hov JR, Jiang X, Melum E (2020)
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin Exp Immunol, 203 (2), 304-314
DOI 10.1111/cei.13541, PubMed 33089489

Vedeld HM, Folseraas T, Lind GE (2020)
Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis - The promise of DNA methylation and molecular biomarkers
JHEP Rep, 2 (5), 100143
DOI 10.1016/j.jhepr.2020.100143, PubMed 32939446

Vesterhus M, Karlsen TH (2020)
Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities
J Gastroenterol, 55 (6), 588-614
DOI 10.1007/s00535-020-01681-z, PubMed 32222826

Vesterhus M, Nielsen MJ, Hov JR, Saffioti F, Manon-Jensen T, Leeming DJ, Moum B, Boberg KM, Pinzani M, Karlsen TH, Karsdal MA, Thorburn D (2020)
Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease
JHEP Rep, 3 (1), 100178
DOI 10.1016/j.jhepr.2020.100178, PubMed 33225252

Publications 2019

Balashova A, Pershin V, Zaborskaya O, Tkachenko N, Mironov A, Guryev E, Kurbatov L, Gainullin M, Mukhina I (2019)
Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice
Front Neurosci, 13, 1033
DOI 10.3389/fnins.2019.01033, PubMed 31632233

Dhillon AK, Kremer AE, Kummen M, Boberg KM, Elferink RPO, Karlsen TH, Beuers U, Vesterhus M, Hov JR (2019)
Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
Sci Rep, 9 (1), 8450
DOI 10.1038/s41598-019-44762-7, PubMed 31186435

Goode EC, Clark AB, Mells GF, Srivastava B, Spiess K, Gelson WTH, Trivedi PJ, Lynch KD, Castren E, Vesterhus MN, Karlsen TH, Ji SG, Anderson CA, Thorburn D, Hudson M, Heneghan MA, Aldersley MA, Bathgate A, Sandford RN, Alexander GJ, Chapman RW, Walmsley M, UK-PSC Consortium, Hirschfield GM, Rushbrook SM (2019)
Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System
Hepatology, 69 (5), 2120-2135
DOI 10.1002/hep.30479, PubMed 30566748

Grimsrud MM, Brekke M, Syse VL, Vallersnes OM (2019)
Acute poisoning related to the recreational use of prescription drugs: an observational study from Oslo, Norway
BMC Emerg Med, 19 (1), 55
DOI 10.1186/s12873-019-0271-0, PubMed 31615421

Grimsrud MM, Folseraas T (2019)
Pathogenesis, diagnosis and treatment of premalignant and malignant stages of cholangiocarcinoma in primary sclerosing cholangitis
Liver Int, 39 (12), 2230-2237
DOI 10.1111/liv.14180, PubMed 31216595

Hole MJ (2019)
[Fulminant bureaucratitis in junior doctors’ titles]
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.19.0176, PubMed 30969047

Hov JR (2019)
Editorial: proton pump inhibition - microbial complications beyond dysbiosis
Aliment Pharmacol Ther, 50 (8), 962-963
DOI 10.1111/apt.15495, PubMed 31591776

Jørgensen SF, Holm K, Macpherson ME, Storm-Larsen C, Kummen M, Fevang B, Aukrust P, Hov JR (2019)
Selective IgA deficiency in humans is associated with reduced gut microbial diversity
J Allergy Clin Immunol, 143 (5), 1969-1971.e11
DOI 10.1016/j.jaci.2019.01.019, PubMed 30707969

Jørgensen SF, Macpherson ME, Bjørnetrø T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Trøseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B (2019)
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9 (1), 167 (Retracted)
DOI 10.1038/s41598-018-35367-7, PubMed 30655568

Karlsen TH, Newsome PN (2019)
The dawn of a new EASL - A new chapter in the history of the European Association for the Study of the liver
J Hepatol, 71 (1), 5-8
DOI 10.1016/j.jhep.2019.03.010, PubMed 31056366

Kummen M, Hov JR (2019)
The gut microbial influence on cholestatic liver disease
Liver Int, 39 (7), 1186-1196
DOI 10.1111/liv.14153, PubMed 31125502

Liwinski T, Zenouzi R, John C, Ehlken H, Rühlemann MC, Bang C, Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JR, Rösch T, Lohse AW, Heeren J, Franke A, Schramm C (2019)
Alterations of the bile microbiome in primary sclerosing cholangitis
Gut, 69 (4), 665-672
DOI 10.1136/gutjnl-2019-318416, PubMed 31243055

Lunder AK, Bakstad LT, Jahnsen J, Borthne A, Hov JR, Vatn M, Negård A (2019)
Assessment of Bowel Inflammation and Strictures by Magnetic Resonance Enterography in Long-term Crohn's Disease
J Crohns Colitis, 13 (5), 607-614
DOI 10.1093/ecco-jcc/jjy208, PubMed 30541145

Maroni L, Pinto C, Giordano DM, Saccomanno S, Banales JM, Spallacci D, Albertini MC, Orlando F, Provinciali M, Milkiewicz M, Melum E, Labiano I, Milkiewicz P, Rychlicki C, Trozzi L, Scarpelli M, Benedetti A, Svegliati Baroni G, Marzioni M (2019)
Aging-Related Expression of Twinfilin-1 Regulates Cholangiocyte Biological Response to Injury
Hepatology, 70 (3), 883-898
DOI 10.1002/hep.30466, PubMed 30561764

Mayerhofer CCK, Awoyemi A, Hov JR, Trøseid M, Broch K (2019)
Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure
ESC Heart Fail, 6 (3), 557-558
DOI 10.1002/ehf2.12437, PubMed 31034162

Mazzawi T, Hausken T, Hov JR, Valeur J, Sangnes DA, El-Salhy M, Gilja OH, Hatlebakk JG, Lied GA (2019)
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels
Scand J Gastroenterol, 54 (6), 690-699
DOI 10.1080/00365521.2019.1624815, PubMed 31190584

Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS (2019)
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin
Nat Immunol, 20 (12), 1644-1655
DOI 10.1038/s41590-019-0504-0, PubMed 31636468

Mjelle AB, Mulabecirovic A, Havre RF, Rosendahl K, Juliusson PB, Olafsdottir E, Gilja OH, Vesterhus M (2019)
Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods
J Pediatr Gastroenterol Nutr, 68 (5), 706-712
DOI 10.1097/MPG.0000000000002320, PubMed 30889132

Mjåland O, Nygaard A, Storm-Larsen C, Brommeland T (2019)
Cycling-related injuries at Sørlandet Hospital, Kristiansand
Tidsskr Nor Laegeforen, 139 (12)
DOI 10.4045/tidsskr.19.0142, PubMed 31502796

Rühlemann M, Liwinski T, Heinsen FA, Bang C, Zenouzi R, Kummen M, Thingholm L, Tempel M, Lieb W, Karlsen T, Lohse A, Hov J, Denk G, Lammert F, Krawczyk M, Schramm C, Franke A (2019)
Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis
Aliment Pharmacol Ther, 50 (5), 580-589
DOI 10.1111/apt.15375, PubMed 31250469

Rühlemann MC, Solovjeva MEL, Zenouzi R, Liwinski T, Kummen M, Lieb W, Hov JR, Schramm C, Franke A, Bang C (2019)
Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species
Gut, 69 (10), 1890-1892
DOI 10.1136/gutjnl-2019-320008, PubMed 31653787

Saffioti F, Roccarina D, Vesterhus M, Hov JR, Rosenberg W, Pinzani M, Pereira SP, Boberg KM, Thorburn D (2019)
Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis
Eur J Clin Invest, 49 (5), e13088
DOI 10.1111/eci.13088, PubMed 30762236

Schneditz G, Elias JE, Pagano E, Zaeem Cader M, Saveljeva S, Long K, Mukhopadhyay S, Arasteh M, Lawley TD, Dougan G, Bassett A, Karlsen TH, Kaser A, Kaneider NC (2019)
GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump
Sci Signal, 12 (562)
DOI 10.1126/scisignal.aau9048, PubMed 30600262

Storm-Larsen C, Myhr KM, Farbu E, Midgard R, Nyquist K, Broch L, Berg-Hansen P, Buness A, Holm K, Ueland T, Fallang LE, Burum-Auensen E, Hov JR, Holmøy T (2019)
Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis - a pilot trial
Mult Scler J Exp Transl Clin, 5 (4), 2055217319888767
DOI 10.1177/2055217319888767, PubMed 31798939

Syse VL, Brekke M, Grimsrud MM, Persett PS, Heyerdahl F, Hovda KE, Vallersnes OM (2019)
Gender differences in acute recreational drug toxicity: a case series from Oslo, Norway
BMC Emerg Med, 19 (1), 29
DOI 10.1186/s12873-019-0244-3, PubMed 31035940

Thingholm LB, Rühlemann MC, Koch M, Fuqua B, Laucke G, Boehm R, Bang C, Franzosa EA, Hübenthal M, Rahnavard A, Frost F, Lloyd-Price J, Schirmer M, Lusis AJ, Vulpe CD, Lerch MM, Homuth G, Kacprowski T, Schmidt CO, Nöthlings U, Karlsen TH, Lieb W, Laudes M, Franke A, Huttenhower C (2019)
Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition
Cell Host Microbe, 26 (2), 252-264.e10
DOI 10.1016/j.chom.2019.07.004, PubMed 31399369

Trøseid M, Mayerhofer CCK, Broch K, Arora S, Svardal A, Hov JR, Andreassen AK, Gude E, Karason K, Dellgren G, Berge RK, Gullestad L, Aukrust P, Ueland T (2019)
The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
J Heart Lung Transplant, 38 (10), 1097-1103
DOI 10.1016/j.healun.2019.06.003, PubMed 31301965

Tysoe OC, Justin AW, Brevini T, Chen SE, Mahbubani KT, Frank AK, Zedira H, Melum E, Saeb-Parsy K, Markaki AE, Vallier L, Sampaziotis F (2019)
Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue
Nat Protoc, 14 (6), 1884-1925
DOI 10.1038/s41596-019-0168-0, PubMed 31110298

Publications 2018

Arnbjerg CJ, Vestad B, Hov JR, Pedersen KK, Jespersen S, Johannesen HH, Holm K, Halvorsen B, Fallentin E, Hansen AE, Lange T, Kjær A, Trøseid M, Fischer BM, Nielsen SD (2018)
Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals
J Acquir Immune Defic Syndr, 78 (4), 450-457
DOI 10.1097/QAI.0000000000001693, PubMed 29874201

Berntsen NL, Fosby B, Tan C, Reims HM, Ogaard J, Jiang X, Schrumpf E, Valestrand L, Karlsen TH, Line PD, Blumberg RS, Melum E (2018)
Natural killer T cells mediate inflammation in the bile ducts
Mucosal Immunol, 11 (6), 1582-1590
DOI 10.1038/s41385-018-0066-8, PubMed 30115993

Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, International FTD-Genomics Consortium, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS et al. (2018)
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
PLoS Med, 15 (1), e1002487
DOI 10.1371/journal.pmed.1002487, PubMed 29315334

Chung BK, Henriksen EKK, Jørgensen KK, Karlsen TH, Hirschfield GM, Liaskou E (2018)
Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease
Hepatol Commun, 2 (8), 956-967
DOI 10.1002/hep4.1200, PubMed 30094406

Colombo M, Karlsen TH (2018)
The EASL International Liver Foundation: A growing pup with missions that are distinct yet integrated with those of its mother
J Hepatol, 70 (3), 339-342
DOI 10.1016/j.jhep.2018.11.017, PubMed 30577976

Dhillon AK, Kummen M, Trøseid M, Åkra S, Liaskou E, Moum B, Vesterhus M, Karlsen TH, Seljeflot I, Hov JR (2018)
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
Liver Int, 39 (2), 371-381
DOI 10.1111/liv.13979, PubMed 30269440

Eaton JE, Vesterhus M, McCauley BM, Atkinson EJ, Schlicht EM, Juran BD, Gossard AA, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN (2018)
Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning
Hepatology, 71 (1), 214-224
DOI 10.1002/hep.30085, PubMed 29742811

Hoel H, Hove-Skovsgaard M, Hov JR, Gaardbo JC, Holm K, Kummen M, Rudi K, Nwosu F, Valeur J, Gelpi M, Seljeflot I, Ueland PM, Gerstoft J, Ullum H, Aukrust P, Nielsen SD, Trøseid M (2018)
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction
Sci Rep, 8 (1), 6725
DOI 10.1038/s41598-018-25168-3, PubMed 29712976

Holmer M, Melum E, Isoniemi H, Ericzon BG, Castedal M, Nordin A, Aagaard Schultz N, Rasmussen A, Line PD, Stål P, Bennet W, Hagström H (2018)
Nonalcoholic fatty liver disease is an increasing indication for liver transplantation in the Nordic countries
Liver Int, 38 (11), 2082-2090
DOI 10.1111/liv.13751, PubMed 29630771

Karlsen TH, Tacke F (2018)
«The times they are a'changin'» - Positioning the European Association for the Study of the Liver in the changing landscape of hepatology
J Hepatol, 68 (5), 873-875
DOI 10.1016/j.jhep.2018.02.001, PubMed 29500035

Kummen M, Mayerhofer CCK, Vestad B, Broch K, Awoyemi A, Storm-Larsen C, Ueland T, Yndestad A, Hov JR, Trøseid M (2018)
Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts
J Am Coll Cardiol, 71 (10), 1184-1186
DOI 10.1016/j.jacc.2017.12.057, PubMed 29519360

Lindström L, Jørgensen KK, Boberg KM, Castedal M, Rasmussen A, Rostved AA, Isoniemi H, Bottai M, Bergquist A (2018)
Risk factors and prognosis for recurrent primary sclerosing cholangitis after liver transplantation: a Nordic Multicentre Study
Scand J Gastroenterol, 53 (3), 297-304
DOI 10.1080/00365521.2017.1421705, PubMed 29301479

Mazzawi T, Lied GA, Sangnes DA, El-Salhy M, Hov JR, Gilja OH, Hatlebakk JG, Hausken T (2018)
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation
PLoS One, 13 (11), e0194904
DOI 10.1371/journal.pone.0194904, PubMed 30427836

Momozawa Y, Dmitrieva J, Théâtre E, Deffontaine V, Rahmouni S, Charloteaux B, Crins F, Docampo E, Elansary M, Gori AS, Lecut C, Mariman R, Mni M, Oury C, Altukhov I, Alexeev D, Aulchenko Y, Amininejad L, Bouma G, Hoentjen F, Löwenberg M, Oldenburg B, Pierik MJ, Vander Meulen-de Jong AE, Janneke van der Woude C et al. (2018)
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
Nat Commun, 9 (1), 2427
DOI 10.1038/s41467-018-04365-8, PubMed 29930244

Mulabecirovic A, Mjelle AB, Gilja OH, Vesterhus M, Havre RF (2018)
Repeatability of shear wave elastography in liver fibrosis phantoms-Evaluation of five different systems
PLoS One, 13 (1), e0189671
DOI 10.1371/journal.pone.0189671, PubMed 29293527

Mulabecirovic A, Mjelle AB, Gilja OH, Vesterhus M, Havre RF (2018)
Liver elasticity in healthy individuals by two novel shear-wave elastography systems-Comparison by age, gender, BMI and number of measurements
PLoS One, 13 (9), e0203486
DOI 10.1371/journal.pone.0203486, PubMed 30216377

Paquin-Proulx D, Greenspun BC, Pasquet L, Strunz B, Aleman S, Falconer K, Terabe M, Berzofsky JA, Sandberg JK, Melum E, Nixon DF, Björkström NK (2018)
IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF⁺ innate T cells in the human liver
Eur J Immunol, 48 (8), 1329-1335
DOI 10.1002/eji.201747334, PubMed 29677387

Pihlstrøm HK, Mjøen G, Mucha S, Franke A, Jardine A, Fellström B, Dahle DO, Holdaas H, Melum E (2018)
Genetic markers associated with long-term cardiovascular outcome in kidney transplant recipients
Am J Transplant, 19 (5), 1444-1451
DOI 10.1111/ajt.15191, PubMed 30457209

Pollheimer MJ, Racedo S, Mikels-Vigdal A, Marshall D, Bowlus C, Lackner C, Madl T, Karlsen TH, Hov JR, Lyman SK, Adamkewicz J, Smith V, Moreau E, Zollner G, Eide TJ, Stojakovic T, Scharnagl H, Gruber HJ, Stauber RE, Trauner M, Fickert P (2018)
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis
J Hepatol, 69 (2), 368-377
DOI 10.1016/j.jhep.2018.04.009, PubMed 29709678

Schmitt C, Lenglet H, Yu A, Delaby C, Benecke A, Lefebvre T, Letteron P, Paradis V, Wahlin S, Sandberg S, Harper P, Sardh E, Sandvik AK, Hov JR, Aarsand AK, Chiche L, Bazille C, Scoazec JY, To-Figueras J, Carrascal M, Abian J, Mirmiran A, Karim Z, Deybach JC, Puy H et al. (2018)
Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver
J Intern Med, 284 (1), 78-91
DOI 10.1111/joim.12750, PubMed 29498764

Schrumpf E, Rizvi SMH (2018)
Pustular drug rash
Tidsskr. Nor. Laegeforen., 138 (18), 1746

Thorgersen EB, Melum E, Folseraas T, Larsen SG, Line PD (2018)
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei in a liver-transplanted patient: a case report
World J Surg Oncol, 16 (1), 180
DOI 10.1186/s12957-018-1482-7, PubMed 30185175

Tronstad RR, Polushina T, Brattbakk HR, Stansberg C, von Volkmann HL, Hanevik K, Ellinghaus E, Jørgensen SF, Ersland KM, Pham KD, Gilja OH, Hovdenak N, Hausken T, Vatn MH, Franke A, Knappskog PM, Le Hellard S, Karlsen TH, Fiskerstrand T (2018)
Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea
Scand J Gastroenterol, 53 (10-11), 1264-1273
DOI 10.1080/00365521.2018.1521867, PubMed 30353760

Åberg F, Isoniemi H, Pukkala E, Jalanko H, Rasmussen A, Storm HH, Schultz N, Bennet W, Ekvall N, Ericzon BG, Malenicka S, Tretli S, Line PD, Boberg KM, Østensen A, Karlsen TH, Nordin A (2018)
Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries
Liver Transpl, 24 (9), 1252-1259
DOI 10.1002/lt.25305, PubMed 30120902

Publications 2017

Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J et al. (2017)
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025

Bende F, Mulabecirovic A, Sporea I, Popescu A, Sirli R, Gilja OH, Vesterhus M, Havre RF (2017)
Assessing Liver Stiffness by 2-D Shear Wave Elastography in a Healthy Cohort
Ultrasound Med Biol, 44 (2), 332-341
DOI 10.1016/j.ultrasmedbio.2017.10.013, PubMed 29249457

Berntsen NL, Fosby B, Valestrand L, Tan C, Reims HM, Schrumpf E, Karlsen TH, Line PD, Melum E (2017)
Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree
Am J Physiol Gastrointest Liver Physiol, 314 (3), G349-G359
DOI 10.1152/ajpgi.00124.2017, PubMed 29212771

Carpino G, Cardinale V, Folseraas T, Overi D, Floreani A, Franchitto A, Onori P, Cazzagon N, Berloco PB, Karlsen TH, Alvaro D, Gaudio E (2017)
Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis
Am J Pathol, 188 (3), 627-639
DOI 10.1016/j.ajpath.2017.11.010, PubMed 29248458

Chung BK, Hirschfield GM (2017)
Immunogenetics in primary sclerosing cholangitis
Curr Opin Gastroenterol, 33 (2), 93-98
DOI 10.1097/MOG.0000000000000336, PubMed 28146446

Chung BK, Karlsen TH (2017)
Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease
Dig Dis, 35 (4), 323-333
DOI 10.1159/000456583, PubMed 28468012

Chung BK, Karlsen TH, Folseraas T (2017)
Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma
Biochim Biophys Acta Mol Basis Dis, 1864 (4 Pt B), 1390-1400
DOI 10.1016/j.bbadis.2017.08.020, PubMed 28844951

Claussen JC, Skiecevičienė J, Wang J, Rausch P, Karlsen TH, Lieb W, Baines JF, Franke A, Hütt MT (2017)
Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome
PLoS Comput Biol, 13 (6), e1005361
DOI 10.1371/journal.pcbi.1005361, PubMed 28640804

de Muinck EJ, Trosvik P, Gilfillan GD, Hov JR, Sundaram AYM (2017)
A novel ultra high-throughput 16S rRNA gene amplicon sequencing library preparation method for the Illumina HiSeq platform
Microbiome, 5 (1), 68
DOI 10.1186/s40168-017-0279-1, PubMed 28683838

de Vries EMG, Färkkilä M, Milkiewicz P, Hov JR, Eksteen B, Thorburn D, Chazouillères O, Pares A, Nygård S, Gilja OH, Wunsch E, Invernizzi P, Carbone M, Bernuzzi F, Boberg KM, Røsjø H, Rosenberg W, Beuers UH, Ponsioen CY, Karlsen TH, Vesterhus M (2017)
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int, 37 (10), 1554-1561
DOI 10.1111/liv.13402, PubMed 28267887

Haissman JM, Haugaard AK, Ostrowski SR, Berge RK, Hov JR, Trøseid M, Nielsen SD (2017)
Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
BMC Infect Dis, 17 (1), 445
DOI 10.1186/s12879-017-2547-x, PubMed 28645263

Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouillères O, Färkkilä M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E, UK-PSC Consortium, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D et al. (2017)
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076, PubMed 28695657

Hov JR, Karlsen TH (2017)
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Semin Liver Dis, 37 (4), 314-331
DOI 10.1055/s-0037-1608801, PubMed 29272894

Hov JR, Kummen M (2017)
Intestinal microbiota in primary sclerosing cholangitis
Curr Opin Gastroenterol, 33 (2), 85-92
DOI 10.1097/MOG.0000000000000334, PubMed 28030369

Jahnsen FL, Bækkevold ES, Hov JR, Landsverk OJ (2017)
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol, 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006, PubMed 29162322

Jahnsen J, Kaasen Jørgensen K (2017)
Experience with Biosimilar Infliximab (Remsima®) in Norway
Dig Dis, 35 (1-2), 83-90
DOI 10.1159/000449088, PubMed 28147374

Jiang X, Björkström NK, Melum E (2017)
Intact CD100-CD72 Interaction Necessary for TCR-Induced T Cell Proliferation
Front Immunol, 8, 765
DOI 10.3389/fimmu.2017.00765, PubMed 28713384

Jiang X, Karlsen TH (2017)
Genetics of primary sclerosing cholangitis and pathophysiological implications
Nat Rev Gastroenterol Hepatol, 14 (5), 279-295
DOI 10.1038/nrgastro.2016.154, PubMed 28293027

Karlsen TH, Folseraas T, Thorburn D, Vesterhus M (2017)
Primary sclerosing cholangitis - a comprehensive review
J Hepatol, 67 (6), 1298-1323
DOI 10.1016/j.jhep.2017.07.022, PubMed 28802875

Koch M, Freitag-Wolf S, Schlesinger S, Borggrefe J, Hov JR, Jensen MK, Pick J, Markus MRP, Höpfner T, Jacobs G, Siegert S, Artati A, Kastenmüller G, Römisch-Margl W, Adamski J, Illig T, Nothnagel M, Karlsen TH, Schreiber S, Franke A, Krawczak M, Nöthlings U, Lieb W (2017)
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
Eur J Clin Nutr, 71 (8), 995-1001
DOI 10.1038/ejcn.2017.43, PubMed 28378853

Landskron J, Kraggerud SM, Wik E, Dørum A, Bjørnslett M, Melum E, Helland Ø, Bjørge L, Lothe RA, Salvesen HB, Taskén K (2017)
C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
PLoS One, 12 (7), e0182030
DOI 10.1371/journal.pone.0182030, PubMed 28759630

Lunder AK, Jahnsen J, Bakstad LT, Borthne A, Hov JR, Vatn M, Negård A, IBSEN Study Group (2017)
Bowel Damage in Patients With Long-term Crohn's Disease, Assessed by Magnetic Resonance Enterography and the Lémann Index
Clin Gastroenterol Hepatol, 16 (1), 75-82.e5
DOI 10.1016/j.cgh.2017.06.053, PubMed 28694130

Maroni L, Hohenester SD, van de Graaf SFJ, Tolenaars D, van Lienden K, Verheij J, Marzioni M, Karlsen TH, Oude Elferink RPJ, Beuers U (2017)
Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice
Hepatology, 66 (2), 542-554
DOI 10.1002/hep.29029, PubMed 28056490

Mayerhofer CCK, Ueland T, Broch K, Vincent RP, Cross GF, Dahl CP, Aukrust P, Gullestad L, Hov JR, Trøseid M (2017)
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
J Card Fail, 23 (9), 666-671
DOI 10.1016/j.cardfail.2017.06.007, PubMed 28688889

Meijerink H, White RA, Løvlie A, de Blasio BF, Dalgard O, Amundsen EJ, Melum E, Kløvstad H (2017)
Modelling the burden of hepatitis C infection among people who inject drugs in Norway, 1973-2030
BMC Infect Dis, 17 (1), 541
DOI 10.1186/s12879-017-2631-2, PubMed 28774261

Nordin A, Åberg F, Pukkala E, Pedersen CR, Storm HH, Rasmussen A, Bennet W, Olausson M, Wilczek H, Ericzon BG, Tretli S, Line PD, Karlsen TH, Boberg KM, Isoniemi H (2017)
Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades
Am J Transplant, 18 (4), 952-963
DOI 10.1111/ajt.14507, PubMed 28925583

O'Hara SP, Karlsen TH, LaRusso NF (2017)
Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link?
Gut, 66 (11), 1873-1877
DOI 10.1136/gutjnl-2017-314249, PubMed 28733279

Rosati E, Dowds CM, Liaskou E, Henriksen EKK, Karlsen TH, Franke A (2017)
Overview of methodologies for T-cell receptor repertoire analysis
BMC Biotechnol, 17 (1), 61
DOI 10.1186/s12896-017-0379-9, PubMed 28693542

Rühlemann MC, Degenhardt F, Thingholm LB, Wang J, Skiecevičienė J, Rausch P, Hov JR, Lieb W, Karlsen TH, Laudes M, Baines JF, Heinsen FA, Franke A (2017)
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
Gut Microbes, 9 (1), 68-75
DOI 10.1080/19490976.2017.1356979, PubMed 28816579

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W et al. (2017)
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids
Nat Med, 23 (8), 954-963
DOI 10.1038/nm.4360, PubMed 28671689

Schrumpf E, Jiang X, Zeissig S, Pollheimer MJ, Anmarkrud JA, Tan C, Exley MA, Karlsen TH, Blumberg RS, Melum E (2017)
The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation
Physiol Rep, 5 (4)
DOI 10.14814/phy2.13117, PubMed 28219981

Trivedi PJ, Tickle J, Vesterhus MN, Eddowes PJ, Bruns T, Vainio J, Parker R, Smith D, Liaskou E, Thorbjørnsen LW, Hirschfield GM, Auvinen K, Hubscher SG, Salmi M, Adams DH, Weston CJ (2017)
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner
Gut, 67 (6), 1135-1145
DOI 10.1136/gutjnl-2016-312354, PubMed 28428344

Tronstad RR, Kummen M, Holm K, von Volkmann HL, Anmarkrud JA, Høivik ML, Moum B, Gilja OH, Hausken T, Baines J, Karlsen TH, Fiskerstrand T, Hov JR (2017)
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Inflamm Bowel Dis, 23 (10), 1752-1761
DOI 10.1097/MIB.0000000000001264, PubMed 28902124

Vesterhus M, Holm A, Hov JR, Nygård S, Schrumpf E, Melum E, Thorbjørnsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJLB, Vatn M, Schaap FG, Jansen PLM, Ueland T, Røsjø H, Moum B, Ponsioen CY, Boberg KM, Färkkilä M, Karlsen TH, Lund-Johansen F (2017)
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472

Volkmann ER, Hoffmann-Vold AM, Chang YL, Jacobs JP, Tillisch K, Mayer EA, Clements PJ, Hov JR, Kummen M, Midtvedt Ø, Lagishetty V, Chang L, Labus JS, Molberg Ø, Braun J (2017)
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts
BMJ Open Gastroenterol, 4 (1), e000134
DOI 10.1136/bmjgast-2017-000134, PubMed 28761687

Weismüller TJ, Trivedi PJ, Bergquist A, Imam M, Lenzen H, Ponsioen CY, Holm K, Gotthardt D, Färkkilä MA, Marschall HU, Thorburn D, Weersma RK, Fevery J, Mueller T, Chazouillères O, Schulze K, Lazaridis KN, Almer S, Pereira SP, Levy C, Mason A, Naess S, Bowlus CL, Floreani A, Halilbasic E et al. (2017)
Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis
Gastroenterology, 152 (8), 1975-1984.e8
DOI 10.1053/j.gastro.2017.02.038, PubMed 28274849

Aabakken L, Karlsen TH, Albert J, Arvanitakis M, Chazouilleres O, Dumonceau JM, Färkkilä M, Fickert P, Hirschfield GM, Laghi A, Marzioni M, Fernandez M, Pereira SP, Pohl J, Poley JW, Ponsioen CY, Schramm C, Swahn F, Tringali A, Hassan C (2017)
Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline
Endoscopy, 49 (6), 588-608
DOI 10.1055/s-0043-107029, PubMed 28420030

Publications 2016

Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D (2016)
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Nat Rev Gastroenterol Hepatol, 13 (5), 261-80
DOI 10.1038/nrgastro.2016.51, PubMed 27095655

Bernuzzi F, Marabita F, Lleo A, Carbone M, Mirolo M, Marzioni M, Alpini G, Alvaro D, Boberg KM, Locati M, Torzilli G, Rimassa L, Piscaglia F, He XS, Bowlus CL, Yang GX, Gershwin ME, Invernizzi P (2016)
Serum microRNAs as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma
Clin Exp Immunol, 185 (1), 61-71
DOI 10.1111/cei.12776, PubMed 26864161

Chung BK, Guevel BT, Reynolds GM, Gupta Udatha DB, Henriksen EK, Stamataki Z, Hirschfield GM, Karlsen TH, Liaskou E (2016)
Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis
J Autoimmun, 77, 45-54
DOI 10.1016/j.jaut.2016.10.003, PubMed 27784538

Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hübenthal M, Folseraas T, Wang Y, Esko T, Metspalu A, Westra HJ, Franke L, Pers TH, Weersma RK, Collij V, D'Amato M, Halfvarson J, Jensen AB, Lieb W, Degenhardt F, Forstner AJ et al. (2016)
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
Nat Genet, 48 (5), 510-8
DOI 10.1038/ng.3528, PubMed 26974007

Gabrielsen IS, Amundsen SS, Helgeland H, Flåm ST, Hatinoor N, Holm K, Viken MK, Lie BA (2016)
Genetic risk variants for autoimmune diseases that influence gene expression in thymus
Hum Mol Genet, 25 (14), 3117-3124
DOI 10.1093/hmg/ddw152, PubMed 27199374

Gabrielsen IS, Viken MK, Amundsen SS, Helgeland H, Holm K, Flåm ST, Lie BA (2016)
Autoimmune risk variants in ERAP2 are associated with gene-expression levels in thymus
Genes Immun, 17 (7), 406-411
DOI 10.1038/gene.2016.39, PubMed 27829666

Henriksen EK, Jørgensen KK, Kaveh F, Holm K, Hamm D, Olweus J, Melum E, Chung BK, Eide TJ, Lundin KE, Boberg KM, Karlsen TH, Hirschfield GM, Liaskou E (2016)
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J Hepatol, 66 (1), 116-122
DOI 10.1016/j.jhep.2016.09.002, PubMed 27647428

Hov JR, Boberg KM, Taraldsrud E, Vesterhus M, Boyadzhieva M, Solberg IC, Schrumpf E, Vatn MH, Lie BA, Molberg Ø, Karlsen TH (2016)
Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
Liver Int, 37 (3), 458-465
DOI 10.1111/liv.13238, PubMed 27558072

Jendrek ST, Gotthardt D, Nitzsche T, Widmann L, Korf T, Michaels MA, Weiss KH, Liaskou E, Vesterhus M, Karlsen TH, Mindorf S, Schemmer P, Bär F, Teegen B, Schröder T, Ehlers M, Hammers CM, Komorowski L, Lehnert H, Fellermann K, Derer S, Hov JR, Sina C (2016)
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
Gut, 66 (1), 137-144
DOI 10.1136/gutjnl-2016-311739, PubMed 27406039

Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L, Melum E, Kumasaka N, Atkinson EJ, Schlicht EM, Liu JZ, Shah T, Gutierrez-Achury J, Boberg KM, Bergquist A, Vermeire S, Eksteen B, Durie PR, Farkkila M, Müller T, Schramm C, Sterneck M, Weismüller TJ, Gotthardt DN, Ellinghaus D, Braun F et al. (2016)
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Nat Genet, 49 (2), 269-273
DOI 10.1038/ng.3745, PubMed 27992413

Jørgensen SF, Macpherson ME, Bjøro K, Karlsen TH, Reims HM, Grzyb K, Fosby B, Fevang B, Aukrust P, Nordøy I (2016)
Liver transplantation in patients with primary antibody deficiency
J Allergy Clin Immunol, 139 (5), 1708-1710.e2
DOI 10.1016/j.jaci.2016.10.025, PubMed 27931972

Jørgensen SF, Reims HM, Frydenlund D, Holm K, Paulsen V, Michelsen AE, Jørgensen KK, Osnes LT, Bratlie J, Eide TJ, Dahl CP, Holter E, Tronstad RR, Hanevik K, Brattbakk HR, Kaveh F, Fiskerstrand T, Kran AB, Ueland T, Karlsen TH, Aukrust P, Lundin KE, Fevang B (2016)
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am J Gastroenterol, 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329, PubMed 27527747

Jørgensen SF, Trøseid M, Kummen M, Anmarkrud JA, Michelsen AE, Osnes LT, Holm K, Høivik ML, Rashidi A, Dahl CP, Vesterhus M, Halvorsen B, Mollnes TE, Berge RK, Moum B, Lundin KE, Fevang B, Ueland T, Karlsen TH, Aukrust P, Hov JR (2016)
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597

Karlsen TH (2016)
Primary sclerosing cholangitis: 50 years of a gut-liver relationship and still no love?
Gut, 65 (10), 1579-81
DOI 10.1136/gutjnl-2016-312137, PubMed 27402486

Knudsen A, Christensen TE, Thorsteinsson K, Ghotbi AA, Hasbak P, Lebech AM, Nielsen SD, Hov JR, Berge R, Ripa RS, Kjær A, Trøseid M (2016)
Microbiota-Dependent Marker TMAO is Not Associated With Decreased Myocardial Perfusion in Well-Treated HIV-Infected Patients as Assessed by 82Rubidium PET/CT
J Acquir Immune Defic Syndr, 72 (4), e83-5
DOI 10.1097/QAI.0000000000001044, PubMed 27152465

Kummen M, Hov JR (2016)
Response to 'Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis' by Rühlemann et al
Gut, 66 (4), 755-756
DOI 10.1136/gutjnl-2016-312347, PubMed 27340191

Kummen M, Vesterhus M, Trøseid M, Moum B, Svardal A, Boberg KM, Aukrust P, Karlsen TH, Berge RK, Hov JR (2016)
Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function
United European Gastroenterol J, 5 (4), 532-541
DOI 10.1177/2050640616663453, PubMed 28588885

Lunder AK, Hov JR, Borthne A, Gleditsch J, Johannesen G, Tveit K, Viktil E, Henriksen M, Hovde Ø, Huppertz-Hauss G, Høie O, Høivik ML, Monstad I, Solberg IC, Jahnsen J, Karlsen TH, Moum B, Vatn M, Negård A (2016)
Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease
Gastroenterology, 151 (4), 660-669.e4
DOI 10.1053/j.gastro.2016.06.021, PubMed 27342213

Maroni L, Agostinelli L, Saccomanno S, Pinto C, Giordano DM, Rychlicki C, De Minicis S, Trozzi L, Banales JM, Melum E, Karlsen TH, Benedetti A, Baroni GS, Marzioni M (2016)
Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes
Am J Pathol, 187 (2), 366-376
DOI 10.1016/j.ajpath.2016.10.010, PubMed 27912077

Mjelle AB, Mulabecirovic A, Hausken T, Havre RF, Gilja OH, Vesterhus M (2016)
Ultrasound and Point Shear Wave Elastography in Livers of Patients with Primary Sclerosing Cholangitis
Ultrasound Med Biol, 42 (9), 2146-55
DOI 10.1016/j.ultrasmedbio.2016.04.016, PubMed 27262519

Mulabecirovic A, Vesterhus M, Gilja OH, Havre RF (2016)
In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology
Ultrasound Med Biol, 42 (11), 2572-2588
DOI 10.1016/j.ultrasmedbio.2016.07.002, PubMed 27570209

Pihlstrøm HK, Mjøen G, Mucha S, Haraldsen G, Franke A, Jardine A, Fellström B, Holdaas H, Melum E (2016)
Single Nucleotide Polymorphisms and Long-Term Clinical Outcome in Renal Transplant Patients: A Validation Study
Am J Transplant, 17 (2), 528-533
DOI 10.1111/ajt.13995, PubMed 27483393

Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Bäckhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E (2016)
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
J Hepatol, 66 (2), 382-389
DOI 10.1016/j.jhep.2016.09.020, PubMed 27720803

Skagen K, Trøseid M, Ueland T, Holm S, Abbas A, Gregersen I, Kummen M, Bjerkeli V, Reier-Nilsen F, Russell D, Svardal A, Karlsen TH, Aukrust P, Berge RK, Hov JE, Halvorsen B, Skjelland M (2016)
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-9
DOI 10.1016/j.atherosclerosis.2016.01.033, PubMed 26868510

Saadati HR, Wittig M, Helbig I, Häsler R, Anderson CA, Mathew CG, Kupcinskas L, Parkes M, Karlsen TH, Rosenstiel P, Schreiber S, Franke A (2016)
Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci
BMC Med Genet, 17, 26
DOI 10.1186/s12881-016-0289-z, PubMed 27037036

Trøseid M, Hov JR, Nestvold TK, Thoresen H, Berge RK, Svardal A, Lappegård KT (2016)
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery
Metab Syndr Relat Disord, 14 (4), 197-201
DOI 10.1089/met.2015.0120, PubMed 27081744

Vesterhus M, Melum E (2016)
Prognostic biomarkers and surrogate end points in PSC
Liver Int, 36 (12), 1748-1751
DOI 10.1111/liv.13216, PubMed 27864874

Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH et al. (2016)
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease
JAMA Neurol, 73 (6), 691-7
DOI 10.1001/jamaneurol.2016.0150, PubMed 27088644

Zweers SJ, Shiryaev A, Komuta M, Vesterhus M, Hov JR, Perugorria MJ, de Waart DR, Chang JC, Tol S, Te Velde AA, de Jonge WJ, Banales JM, Roskams T, Beuers U, Karlsen TH, Jansen PL, Schaap FG (2016)
Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis
Liver Int, 36 (9), 1370-7
DOI 10.1111/liv.13092, PubMed 26866350

Publications 2015

Andersen IM, Fosby B, Boberg KM, Clausen OP, Jebsen P, Melum E, Line PD, Foss A, Schrumpf E, Karlsen TH (2015)
Indications and Outcomes in Liver Transplantation in Patients With Primary Sclerosing Cholangitis in Norway
Transplant Direct, 1 (9), e39
DOI 10.1097/TXD.0000000000000548, PubMed 27500239

Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM (2015)
Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms
PLoS One, 10 (4), e0123057
DOI 10.1371/journal.pone.0123057, PubMed 25853426

Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM (2015)
Correction: Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms
PLoS One, 10 (5), e0128048
DOI 10.1371/journal.pone.0128048, PubMed 25978331

Andresen K, Boberg KM, Vedeld HM, Honne H, Jebsen P, Hektoen M, Wadsworth CA, Clausen OP, Lundin KE, Paulsen V, Foss A, Mathisen Ø, Aabakken L, Schrumpf E, Lothe RA, Lind GE (2015)
Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma
Hepatology, 61 (5), 1651-9
DOI 10.1002/hep.27707, PubMed 25644509

Berntsen NL, Klingenberg O, Juran BD, Benito de Valle M, Lindkvist B, Lazaridis KN, Boberg KM, Karlsen TH, Hov JR (2015)
Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
Gastroenterology, 148 (5), 924-927.e2
DOI 10.1053/j.gastro.2015.01.041, PubMed 25655558

Carpino G, Cardinale V, Renzi A, Hov JR, Berloco PB, Rossi M, Karlsen TH, Alvaro D, Gaudio E (2015)
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
J Hepatol, 63 (5), 1220-8
DOI 10.1016/j.jhep.2015.06.018, PubMed 26119688

Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, Andersen V, Andrews JM, Annese V, Brand S, Brant SR, Cho JH, Daly MJ, Dubinsky M, Duerr RH, Ferguson LR, Franke A, Gearry RB, Goyette P, Hakonarson H, Halfvarson J, Hov JR, Huang H, Kennedy NA, Kupcinskas L et al. (2015)
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Lancet, 387 (10014), 156-67
DOI 10.1016/S0140-6736(15)00465-1, PubMed 26490195

D'Agnolo HM, Kievit W, Andrade RJ, Karlsen TH, Wedemeyer H, Drenth JP (2015)
Creating an effective clinical registry for rare diseases
United European Gastroenterol J, 4 (3), 333-8
DOI 10.1177/2050640615618042, PubMed 27403298

Folseraas T, Boberg KM (2015)
Cancer Risk and Surveillance in Primary Sclerosing Cholangitis
Clin Liver Dis, 20 (1), 79-98
DOI 10.1016/j.cld.2015.08.014, PubMed 26593292

Folseraas T, Liaskou E, Anderson CA, Karlsen TH (2015)
Genetics in PSC: what do the "risk genes" teach us?
Clin Rev Allergy Immunol, 48 (2-3), 154-64
DOI 10.1007/s12016-014-8417-z, PubMed 24736995

Fosby B, Melum E, Bjøro K, Bennet W, Rasmussen A, Andersen IM, Castedal M, Olausson M, Wibeck C, Gotlieb M, Gjertsen H, Toivonen L, Foss S, Makisalo H, Nordin A, Sanengen T, Bergquist A, Larsson ME, Soderdahl G, Nowak G, Boberg KM, Isoniemi H, Keiding S, Foss A, Line PD et al. (2015)
Liver transplantation in the Nordic countries - An intention to treat and post-transplant analysis from The Nordic Liver Transplant Registry 1982-2013
Scand J Gastroenterol, 50 (6), 797-808
DOI 10.3109/00365521.2015.1036359, PubMed 25959101

Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S, International Inflammatory Bowel Disease Genetics Consortium, Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium, Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium, United Kingdom IBDGC, Wellcome Trust Case Control Consortium, Quebec IBD Genetics Consortium, Daly MJ, Van Steen K, Duerr RH, Barrett JC et al. (2015)
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
Nat Genet, 47 (2), 172-9
DOI 10.1038/ng.3176, PubMed 25559196

Hov JE, Trøseid M (2015)
Personalised medicine targeting the gut microbiota?
Tidsskr Nor Laegeforen, 135 (7), 624
DOI 10.4045/tidsskr.14.1431, PubMed 25899345

Hov JER, Troseid M (2015)
Personalized intestinal flora medicine?
Tidsskr. Nor. Laegeforen., 135 (7), 624

Hov JR, Zhong H, Qin B, Anmarkrud JA, Holm K, Franke A, Lie BA, Karlsen TH (2015)
The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study
PLoS One, 10 (7), e0133804
DOI 10.1371/journal.pone.0133804, PubMed 26207384

Karlsen TH, Chung BK (2015)
Genetic Risk and the Development of Autoimmune Liver Disease
Dig Dis, 33 Suppl 2, 13-24
DOI 10.1159/000440706, PubMed 26641277

Karlsen TH, Lammert F, Thompson RJ (2015)
Genetics of liver disease: From pathophysiology to clinical practice
J Hepatol, 62 (1 Suppl), S6-S14
DOI 10.1016/j.jhep.2015.02.025, PubMed 25920091

Kevans D, Tyler AD, Holm K, Jørgensen KK, Vatn MH, Karlsen TH, Kaplan GG, Eksteen B, Gevers D, Hov JR, Silverberg MS (2015)
Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis
J Crohns Colitis, 10 (3), 330-7
DOI 10.1093/ecco-jcc/jjv204, PubMed 26526357

Li J, Jørgensen SF, Maggadottir SM, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E, Resnick E, Goldacker S, Buchta M, Witte T, Padyukov L, Videm V, Folseraas T, Atschekzei F, Elder JT, Nair RP, Winkelmann J, Gieger C, Nöthen MM, Büning C, Brand S et al. (2015)
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells
Nat Commun, 6, 6804
DOI 10.1038/ncomms7804, PubMed 25891430

Liaskou E, Klemsdal Henriksen EK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM (2015)
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-19
DOI 10.1002/hep.28116, PubMed 26257205

Olin P, Hausken J, Foss A, Karlsen TH, Melum E, Haugaa H (2015)
Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation
Scand J Gastroenterol, 50 (9), 1127-34
DOI 10.3109/00365521.2015.1027262, PubMed 25865318

Ponsioen CY, Chapman RW, Chazouillères O, Hirschfield GM, Karlsen TH, Lohse AW, Pinzani M, Schrumpf E, Trauner M, Gores GJ (2015)
Surrogate endpoints for clinical trials in primary sclerosing cholangitis: Review and results from an International PSC Study Group consensus process
Hepatology, 63 (4), 1357-67
DOI 10.1002/hep.28256, PubMed 26418478

Sampaziotis F, de Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WT, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L (2015)
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
Nat Biotechnol, 33 (8), 845-852
DOI 10.1038/nbt.3275, PubMed 26167629

Schrumpf E, Boberg KM, Karlsen TH (2015)
Primary sclerosing cholangitis - the Norwegian experience
Scand J Gastroenterol, 50 (6), 781-96
DOI 10.3109/00365521.2015.1028996, PubMed 25866138

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E (2015)
The biliary epithelium presents antigens to and activates natural killer T cells
Hepatology, 62 (4), 1249-59
DOI 10.1002/hep.27840, PubMed 25855031

Stiksrud B, Nowak P, Nwosu FC, Kvale D, Thalme A, Sonnerborg A, Ueland PM, Holm K, Birkeland SE, Dahm AE, Sandset PM, Rudi K, Hov JR, Dyrhol-Riise AM, Trøseid M (2015)
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART
J Acquir Immune Defic Syndr, 70 (4), 329-37
DOI 10.1097/QAI.0000000000000784, PubMed 26258571

Thorsen T, Dahlgren US, Aandahl EM, Grzyb K, Karlsen TH, Boberg KM, Rydberg L, Naper C, Foss A, Bennet W (2015)
Liver transplantation with deceased ABO-incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications
Transpl Int, 28 (7), 800-12
DOI 10.1111/tri.12552, PubMed 25736519

Thorsen T, Aandahl EM, Bennet W, Olausson M, Ericzon BG, Nowak G, Duraj F, Isoniemi H, Rasmussen A, Karlsen TH, Foss A (2015)
Transplantation With Livers From Deceased Donors Older Than 75 Years
Transplantation, 99 (12), 2534-42
DOI 10.1097/TP.0000000000000728, PubMed 25909464

Vesterhus M, Hov JR, Holm A, Schrumpf E, Nygård S, Godang K, Andersen IM, Naess S, Thorburn D, Saffioti F, Vatn M, Gilja OH, Lund-Johansen F, Syversveen T, Brabrand K, Parés A, Ponsioen CY, Pinzani M, Färkkilä M, Moum B, Ueland T, Røsjø H, Rosenberg W, Boberg KM, Karlsen TH (2015)
Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis
Hepatology, 62 (1), 188-97
DOI 10.1002/hep.27825, PubMed 25833813

Vukcevic D, Traherne JA, Næss S, Ellinghaus E, Kamatani Y, Dilthey A, Lathrop M, Karlsen TH, Franke A, Moffatt M, Cookson W, Trowsdale J, McVean G, Sawcer S, Leslie S (2015)
Imputation of KIR Types from SNP Variation Data
Am J Hum Genet, 97 (4), 593-607
DOI 10.1016/j.ajhg.2015.09.005, PubMed 26430804

Wannhoff A, Folseraas T, Brune M, Rupp C, Friedrich K, Knierim J, Weiss KH, Sauer P, Flechtenmacher C, Schirmacher P, Stremmel W, Hov JR, Gotthardt DN (2015)
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
United European Gastroenterol J, 4 (1), 84-91
DOI 10.1177/2050640615581577, PubMed 26966527

Wittig M, Anmarkrud JA, Kässens JC, Koch S, Forster M, Ellinghaus E, Hov JR, Sauer S, Schimmler M, Ziemann M, Görg S, Jacob F, Karlsen TH, Franke A (2015)
Development of a high-resolution NGS-based HLA-typing and analysis pipeline
Nucleic Acids Res, 43 (11), e70
DOI 10.1093/nar/gkv184, PubMed 25753671

Åberg F, Gissler M, Karlsen TH, Ericzon BG, Foss A, Rasmussen A, Bennet W, Olausson M, Line PD, Nordin A, Bergquist A, Boberg KM, Castedal M, Pedersen CR, Isoniemi H (2015)
Differences in long-term survival among liver transplant recipients and the general population: a population-based Nordic study
Hepatology, 61 (2), 668-77
DOI 10.1002/hep.27538, PubMed 25266201

Publications 2014

Eskesen AN, Bjøro K, Aandahl EM, Line PD, Melum E (2014)
Low use of surveillance and early diagnosis of hepatocellular carcinoma in Norway--a population-based cohort study
Cancer Epidemiol, 38 (6), 741-7
DOI 10.1016/j.canep.2014.10.005, PubMed 25454262

Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M, International PSC Study Group (IPSCSG) (2014)
Characterization of animal models for primary sclerosing cholangitis (PSC)
J Hepatol, 60 (6), 1290-303
DOI 10.1016/j.jhep.2014.02.006, PubMed 24560657

Flachsbart F, Caliebe A, Heinsen FA, Hemming-Karlsen T, Schreiber S, Franke A, Nebel A (2014)
Investigation of complement component C4 copy number variation in human longevity
PLoS One, 9 (1), e86188
DOI 10.1371/journal.pone.0086188, PubMed 24465950

Fosby B, Næss S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH (2014)
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
World J Gastroenterol, 20 (14), 3986-4000
DOI 10.3748/wjg.v20.i14.3986, PubMed 24744588

Friedrich K, Wannhoff A, Kattner S, Brune M, Hov JR, Weiss KH, Antoni C, Dollinger M, Neumann-Haefelin C, Seufferlein T, Schemmer P, Schirmacher P, Stremmel W, Gotthardt DN (2014)
PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival
J Gastroenterol Hepatol, 29 (7), 1477-84
DOI 10.1111/jgh.12540, PubMed 25273282

Henriksen EK, Melum E, Karlsen TH (2014)
Update on primary sclerosing cholangitis genetics
Curr Opin Gastroenterol, 30 (3), 310-9
DOI 10.1097/MOG.0000000000000052, PubMed 24565892

Hirschfield GM, Karlsen TH (2014)
Genetic risks link autoimmune hepatitis to other autoimmune liver disease
Gastroenterology, 147 (2), 270-3
DOI 10.1053/j.gastro.2014.06.020, PubMed 24973678

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS (2014)
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Nature, 517 (7534), 386-90
DOI 10.1038/nature13848, PubMed 25363763

Naess S, Björnsson E, Anmarkrud JA, Al Mamari S, Juran BD, Lazaridis KN, Chapman R, Bergquist A, Melum E, Marsh SG, Schrumpf E, Lie BA, Boberg KM, Karlsen TH, Hov JR (2014)
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease
Liver Int, 34 (10), 1488-95
DOI 10.1111/liv.12492, PubMed 24517468

Næss S, Lie BA, Melum E, Olsson M, Hov JR, Croucher PJ, Hampe J, Thorsby E, Bergquist A, Traherne JA, Schrumpf E, Boberg KM, Schreiber S, Franke A, Karlsen TH (2014)
Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
PLoS One, 9 (12), e114486
DOI 10.1371/journal.pone.0114486, PubMed 25521205

Rupp C, Friedrich K, Folseraas T, Wannhoff A, Bode KA, Weiss KH, Schirmacher P, Sauer P, Stremmel W, Gotthardt DN (2014)
Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis
Aliment Pharmacol Ther, 39 (8), 873-82
DOI 10.1111/apt.12663, PubMed 24612312

Vedeld HM, Andresen K, Eilertsen IA, Nesbakken A, Seruca R, Gladhaug IP, Thiis-Evensen E, Rognum TO, Boberg KM, Lind GE (2014)
The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers
Int J Cancer, 136 (4), 844-53
DOI 10.1002/ijc.29039, PubMed 24948044

Zeissig S, Petersen BS, Tomczak M, Melum E, Huc-Claustre E, Dougan SK, Laerdahl JK, Stade B, Forster M, Schreiber S, Weir D, Leichtner AM, Franke A, Blumberg RS (2014)
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4
Gut, 64 (12), 1889-97
DOI 10.1136/gutjnl-2014-308541, PubMed 25367873

Publications 2013

Andersen IM, Tengesdal G, Lie BA, Boberg KM, Karlsen TH, Hov JR (2013)
Effects of coffee consumption, smoking, and hormones on risk for primary sclerosing cholangitis
Clin Gastroenterol Hepatol, 12 (6), 1019-28
DOI 10.1016/j.cgh.2013.09.024, PubMed 24076415

Block M, Jørgensen KK, Oresland T, Lindholm E, Grzyb K, Cvancarova M, Vatn MH, Boberg KM, Börjesson L (2013)
Colectomy for patients with ulcerative colitis and primary sclerosing cholangitis - what next?
J Crohns Colitis, 8 (5), 421-30
DOI 10.1016/j.crohns.2013.10.008, PubMed 24239402

Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismüller TJ, Schramm C, Wittig M, Bergquist A, Björnsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK et al. (2013)
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-83
DOI 10.1002/hep.25977, PubMed 22821403

Ellinghaus D, Zhang H, Zeissig S, Lipinski S, Till A, Jiang T, Stade B, Bromberg Y, Ellinghaus E, Keller A, Rivas MA, Skieceviciene J, Doncheva NT, Liu X, Liu Q, Jiang F, Forster M, Mayr G, Albrecht M, Häsler R, Boehm BO, Goodall J, Berzuini CR, Lee J, Andersen V et al. (2013)
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies
Gastroenterology, 145 (2), 339-47
DOI 10.1053/j.gastro.2013.04.040, PubMed 23624108

Friedrich K, Rupp C, Hov JR, Steinebrunner N, Weiss KH, Stiehl A, Brune M, Schaefer PK, Schemmer P, Sauer P, Schirmacher P, Runz H, Karlsen TH, Stremmel W, Gotthardt DN (2013)
A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis
PLoS One, 8 (3), e58734
DOI 10.1371/journal.pone.0058734, PubMed 23505555

Hirschfield GM, Karlsen TH, Lindor KD, Adams DH (2013)
Primary sclerosing cholangitis
Lancet, 382 (9904), 1587-99
DOI 10.1016/S0140-6736(13)60096-3, PubMed 23810223

Jørgensen KK, Lindström L, Cvancarova M, Karlsen TH, Castedal M, Friman S, Schrumpf E, Foss A, Isoniemi H, Nordin A, Holte K, Rasmussen A, Bergquist A, Vatn MH, Boberg KM (2013)
Immunosuppression after liver transplantation for primary sclerosing cholangitis influences activity of inflammatory bowel disease
Clin Gastroenterol Hepatol, 11 (5), 517-23
DOI 10.1016/j.cgh.2012.12.027, PubMed 23333218

Karlsen TH, Boberg KM (2013)
Update on primary sclerosing cholangitis
J Hepatol, 59 (3), 571-82
DOI 10.1016/j.jhep.2013.03.015, PubMed 23603668

Karlsen TH, Vesterhus M, Boberg KM (2013)
Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis
Aliment Pharmacol Ther, 39 (3), 282-301
DOI 10.1111/apt.12581, PubMed 24372568

Kummen M, Schrumpf E, Boberg KM (2013)
Liver abnormalities in bowel diseases
Best Pract Res Clin Gastroenterol, 27 (4), 531-42
DOI 10.1016/j.bpg.2013.06.013, PubMed 24090940

Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S et al. (2013)
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nat Genet, 45 (6), 670-5
DOI 10.1038/ng.2616, PubMed 23603763

Mells GF, Kaser A, Karlsen TH (2013)
Novel insights into autoimmune liver diseases provided by genome-wide association studies
J Autoimmun, 46, 41-54
DOI 10.1016/j.jaut.2013.07.004, PubMed 23931959

Wannhoff A, Hov JR, Folseraas T, Rupp C, Friedrich K, Anmarkrud JA, Weiss KH, Sauer P, Schirmacher P, Boberg KM, Stremmel W, Karlsen TH, Gotthardt DN (2013)
FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
J Hepatol, 59 (6), 1278-84
DOI 10.1016/j.jhep.2013.08.005, PubMed 23958938

Publications 2012

Andresen K, Boberg KM, Vedeld HM, Honne H, Hektoen M, Wadsworth CA, Clausen OP, Karlsen TH, Foss A, Mathisen O, Schrumpf E, Lothe RA, Lind GE (2012)
Novel target genes and a valid biomarker panel identified for cholangiocarcinoma
Epigenetics, 7 (11), 1249-57
DOI 10.4161/epi.22191, PubMed 22983262

Eskesen AN, Melum E, Moghaddam A, Bjøro K, Verbaan H, Ring-Larsen H, Dalgard O (2012)
Genetic variants at the ITPA locus protect against ribavirin-induced hemolytic anemia and dose reduction in an HCV G2/G3 cohort
Eur J Gastroenterol Hepatol, 24 (8), 890-6
DOI 10.1097/MEG.0b013e3283546efd, PubMed 22584257

Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE et al. (2012)
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J Hepatol, 57 (2), 366-75
DOI 10.1016/j.jhep.2012.03.031, PubMed 22521342

Forster M, Forster P, Elsharawy A, Hemmrich G, Kreck B, Wittig M, Thomsen I, Stade B, Barann M, Ellinghaus D, Petersen BS, May S, Melum E, Schilhabel MB, Keller A, Schreiber S, Rosenstiel P, Franke A (2012)
From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software
Nucleic Acids Res, 41 (1), e16
DOI 10.1093/nar/gks836, PubMed 22965131

Fosby B, Karlsen TH, Melum E (2012)
Recurrence and rejection in liver transplantation for primary sclerosing cholangitis
World J Gastroenterol, 18 (1), 1-15
DOI 10.3748/wjg.v18.i1.1, PubMed 22228965

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V et al. (2012)
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature, 491 (7422), 119-24
DOI 10.1038/nature11582, PubMed 23128233

Jørgensen KK, Lindström L, Cvancarova M, Castedal M, Friman S, Schrumpf E, Foss A, Isoniemi H, Nordin A, Holte K, Rasmussen A, Bergquist A, Vatn MH, Boberg KM (2012)
Colorectal neoplasia in patients with primary sclerosing cholangitis undergoing liver transplantation: a Nordic multicenter study
Scand J Gastroenterol, 47 (8-9), 1021-9
DOI 10.3109/00365521.2012.685754, PubMed 22577871

Karlsen TH (2012)
A lecture on the genetics of primary sclerosing cholangitis
Dig Dis, 30 Suppl 1, 32-8
DOI 10.1159/000341122, PubMed 23075866

Metzger J, Negm AA, Plentz RR, Weismüller TJ, Wedemeyer J, Karlsen TH, Dakna M, Mullen W, Mischak H, Manns MP, Lankisch TO (2012)
Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders
Gut, 62 (1), 122-30
DOI 10.1136/gutjnl-2012-302047, PubMed 22580416

Munk S, Dalsgaard J, Bjerggaard K, Andersen I, Hansen TB, Kehlet H (2012)
Early recovery after fast-track Oxford unicompartmental knee arthroplasty. 35 patients with minimal invasive surgery
Acta Orthop, 83 (1), 41-5
DOI 10.3109/17453674.2012.657578, PubMed 22313368

Næss S, Shiryaev A, Hov JR, Franke A, Karlsen TH (2012)
Genetics in primary sclerosing cholangitis
Clin Res Hepatol Gastroenterol, 36 (4), 325-33
DOI 10.1016/j.clinre.2012.02.003, PubMed 22554879

Srivastava B, Mells GF, Cordell HJ, Muriithi A, Brown M, Ellinghaus E, Franke A, UK-PSC Consortium, Karlsen TH, Sandford RN, Alexander GJ, Chapman RW, Rushbrook SM, Melum E (2012)
Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis
Scand J Gastroenterol, 47 (7), 820-6
DOI 10.3109/00365521.2012.682090, PubMed 22554193

Publications 2011

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C et al. (2011)
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Nat Genet, 43 (3), 246-52
DOI 10.1038/ng.764, PubMed 21297633

Boberg KM, Lind GE (2011)
Primary sclerosing cholangitis and malignancy
Best Pract Res Clin Gastroenterol, 25 (6), 753-64
DOI 10.1016/j.bpg.2011.10.002, PubMed 22117640

Folseraas T, Karlsen TH (2011)
To MMP or not to MMP: a role for matrix metalloproteinase 3 in primary sclerosing cholangitis?
Liver Int, 31 (6), 751-4
DOI 10.1111/j.1478-3231.2011.02471.x, PubMed 21645205

Folseraas T, Melum E, Franke A, Karlsen TH (2011)
Genetics in primary sclerosing cholangitis
Best Pract Res Clin Gastroenterol, 25 (6), 713-26
DOI 10.1016/j.bpg.2011.09.010, PubMed 22117637

Holm A, Wu W, Lund-Johansen F (2011)
Antibody array analysis of labelled proteomes: how should we control specificity?
N Biotechnol, 29 (5), 578-85
DOI 10.1016/j.nbt.2011.07.008, PubMed 21840428

Hov JR, Keitel V, Schrumpf E, Häussinger D, Karlsen TH (2011)
TGR5 sequence variation in primary sclerosing cholangitis
Dig Dis, 29 (1), 78-84
DOI 10.1159/000324138, PubMed 21691110

Hov JR, Kosmoliaptsis V, Traherne JA, Olsson M, Boberg KM, Bergquist A, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH (2011)
Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis
Hepatology, 53 (6), 1967-76
DOI 10.1002/hep.24299, PubMed 21413052

Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismüller TJ, Wedemeyer J, Schramm C, Sterneck M, Günther R, Braun F et al. (2011)
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
Hepatology, 53 (6), 1977-85
DOI 10.1002/hep.24307, PubMed 21425313

Jørgensen KK, Grzyb K, Lundin KE, Clausen OP, Aamodt G, Schrumpf E, Vatn MH, Boberg KM (2011)
Inflammatory bowel disease in patients with primary sclerosing cholangitis: clinical characterization in liver transplanted and nontransplanted patients
Inflamm Bowel Dis, 18 (3), 536-45
DOI 10.1002/ibd.21699, PubMed 21456044

Karlsen TH, Kaser A (2011)
Deciphering the genetic predisposition to primary sclerosing cholangitis
Semin Liver Dis, 31 (2), 188-207
DOI 10.1055/s-0031-1276647, PubMed 21538284

Karlsen TH, Lazaridis KN (2011)
At the end of the beginning. Foreword
Semin Liver Dis, 31 (2), 111-3
DOI 10.1055/s-0031-1276640, PubMed 21538278

Moghaddam A, Melum E, Reinton N, Ring-Larsen H, Verbaan H, Bjøro K, Dalgard O (2011)
IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection
Hepatology, 53 (3), 746-54
DOI 10.1002/hep.24154, PubMed 21374656

Naalsund A, Lund MB, Mynarek G, Aakhus S, Boberg KM, Nordøy I (2011)
[A man in his 60s with severe respiratory failure]
Tidsskr Nor Laegeforen, 131 (17), 1654-7
DOI 10.4045/tidsskr.11.0110, PubMed 21901039

Wiencke K, Boberg KM (2011)
Current consensus on the management of primary sclerosing cholangitis
Clin Res Hepatol Gastroenterol, 35 (12), 786-91
DOI 10.1016/j.clinre.2011.04.007, PubMed 21963085

Publications 2010

Boberg KM, Chapman RW, Hirschfield GM, Lohse AW, Manns MP, Schrumpf E, International Autoimmune Hepatitis Group (2010)
Overlap syndromes: the International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue
J Hepatol, 54 (2), 374-85
DOI 10.1016/j.jhep.2010.09.002, PubMed 21067838

Bowlus CL, Li CS, Karlsen TH, Lie BA, Selmi C (2010)
Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations
Liver Transpl, 16 (11), 1324-30
DOI 10.1002/lt.22161, PubMed 21031548

Chapman R, Fevery J, Kalloo A, Nagorney DM, Boberg KM, Shneider B, Gores GJ, American Association for the Study of Liver Diseases (2010)
Diagnosis and management of primary sclerosing cholangitis
Hepatology, 51 (2), 660-78
DOI 10.1002/hep.23294, PubMed 20101749

Dolgos S, Hartmann A, Isaksen GA, Simonsen S, Bjørtuft Ø, Boberg KM, Bollerslev J (2010)
Osteoporosis is a prevalent finding in patients with solid organ failure awaiting transplantation - a population based study
Clin Transplant, 24 (5), E145-52
DOI 10.1111/j.1399-0012.2010.01231.x, PubMed 20236290

Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Belouchi M, Fournier H, Reinhard C, Ding J, Li Y, Tejasvi T, Gudjonsson J, Stoll SW, Voorhees JJ, Lambert S, Weidinger S, Eberlein B, Kunz M, Rahman P, Gladman DD, Gieger C, Wichmann HE, Karlsen TH, Mayr G et al. (2010)
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
Nat Genet, 42 (11), 991-5
DOI 10.1038/ng.689, PubMed 20953188

Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH, IBSEN study group, Krawczak M et al. (2010)
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
Nat Genet, 42 (4), 292-4
DOI 10.1038/ng.553, PubMed 20228798

Friman S, Foss A, Isoniemi H, Olausson M, Höckerstedt K, Yamamoto S, Karlsen TH, Rizell M, Ericzon BG (2010)
Liver transplantation for cholangiocarcinoma: selection is essential for acceptable results
Scand J Gastroenterol, 46 (3), 370-5
DOI 10.3109/00365521.2010.533384, PubMed 21073376

Hollenbach JA, Meenagh A, Sleator C, Alaez C, Bengoche M, Canossi A, Contreras G, Creary L, Evseeva I, Gorodezky C, Hardie RA, Karlsen TH, Lie B, Luo M, Martinetti M, Navarette C, de Oliveira DC, Ozzella G, Pasi A, Pavlova E, Pinto S, Porto LC, Santos P, Slavcev A, Srinak D et al. (2010)
Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA
Tissue Antigens, 76 (1), 9-17
DOI 10.1111/j.1399-0039.2010.01459.x, PubMed 20331834

Holm K, Melum E, Franke A, Karlsen TH (2010)
SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
BMC Bioinformatics, 11, 600
DOI 10.1186/1471-2105-11-600, PubMed 21167019

Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH et al. (2010)
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
PLoS One, 5 (8), e12403
DOI 10.1371/journal.pone.0012403, PubMed 20811628

Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P (2010)
Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C
J Hepatol, 52 (5), 712-7
DOI 10.1016/j.jhep.2009.11.029, PubMed 20347497

Karlsen TH, Hov JR (2010)
Genetics of cholestatic liver disease in 2010
Curr Opin Gastroenterol, 26 (3), 251-8
DOI 10.1097/MOG.0b013e328336807d, PubMed 20042859

Karlsen TH, Melum E, Franke A (2010)
The utility of genome-wide association studies in hepatology
Hepatology, 51 (5), 1833-42
DOI 10.1002/hep.23564, PubMed 20232293

Karlsen TH, Schrumpf E, Boberg KM (2010)
Update on primary sclerosing cholangitis
Dig Liver Dis, 42 (6), 390-400
DOI 10.1016/j.dld.2010.01.011, PubMed 20172772

Karlsen TH, Schrumpf E, Boberg KM (2010)
Primary sclerosing cholangitis
Best Pract Res Clin Gastroenterol, 24 (5), 655-66
DOI 10.1016/j.bpg.2010.07.005, PubMed 20955968

Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF (2010)
Association to the Glypican-5 gene in multiple sclerosis
J Neuroimmunol, 226 (1-2), 194-7
DOI 10.1016/j.jneuroim.2010.07.003, PubMed 20692050

Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M et al. (2010)
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nat Genet, 43 (1), 17-9
DOI 10.1038/ng.728, PubMed 21151127

Melum E, May S, Schilhabel MB, Thomsen I, Karlsen TH, Rosenstiel P, Schreiber S, Franke A (2010)
SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region
Hum Mutat, 31 (7), 875-85
DOI 10.1002/humu.21276, PubMed 20506538

Ponsioen CY, Reitsma JB, Boberg KM, Aabakken L, Rauws EA, Schrumpf E (2010)
Validation of a cholangiographic prognostic model in primary sclerosing cholangitis
Endoscopy, 42 (9), 742-7
DOI 10.1055/s-0030-1255527, PubMed 20623444

Publications 2009

Forsbring M, Vik ES, Dalhus B, Karlsen TH, Bergquist A, Schrumpf E, Bjørås M, Boberg KM, Alseth I (2009)
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
Carcinogenesis, 30 (7), 1147-54
DOI 10.1093/carcin/bgp118, PubMed 19443904

Karlsen TH (2009)
Genome-wide association studies reach hepatology
J Hepatol, 50 (6), 1278-80
DOI 10.1016/j.jhep.2009.03.002, PubMed 19395112

Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P et al. (2009)
Genome-wide association analysis in primary sclerosing cholangitis
Gastroenterology, 138 (3), 1102-11
DOI 10.1053/j.gastro.2009.11.046, PubMed 19944697

Lorentzen AR, Karlsen TH, Olsson M, Smestad C, Mero IL, Woldseth B, Sun JY, Senitzer D, Celius EG, Thorsby E, Spurkland A, Lie BA, Harbo HF (2009)
Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
Ann Neurol, 65 (6), 658-66
DOI 10.1002/ana.21695, PubMed 19630074

Melum E, Franke A, Karlsen TH (2009)
Genome-wide association studies--a summary for the clinical gastroenterologist
World J Gastroenterol, 15 (43), 5377-96
DOI 10.3748/wjg.15.5377, PubMed 19916168

Michalsen S, Schrumpf E, Beiske K, Tierens A, Stenberg V, Tjønnfjord GE (2009)
[Large granular lymphocytic leukaemia]
Tidsskr Nor Laegeforen, 129 (11), 1098-102
DOI 10.4045/tidsskr.09.0152, PubMed 19488091

Scholz T, Karlsen TH, Sanengen T, Schrumpf E, Line PD, Boberg KM, Jörgensen PF, Fosby B, Bentdal O, Ostensen AB, Osnes S, Riddervold F, Haugaa H, Hausken J, Bergmann JB, Foss S, Björo K, Foss A, Levertransplantasjonsgruppen ved Oslo universitetssykehus, Rikshospitalet (2009)
[Liver transplantation in Norway through 25 years]
Tidsskr Nor Laegeforen, 129 (24), 2587-92
DOI 10.4045/tidsskr.09.1106, PubMed 20029553

Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, Karlsen TH, Boberg KM, Bergquist A, Kunz M, Witte T, Gross WL, Epplen JT, Alarcón-Riquelme ME, Schreiber S, Ibrahim SM (2009)
Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases
Genes Immun, 10 (6), 601-5
DOI 10.1038/gene.2009.29, PubMed 19387457

Publications 2008

Björnsson E, Olsson R, Bergquist A, Lindgren S, Braden B, Chapman RW, Boberg KM, Angulo P (2008)
The natural history of small-duct primary sclerosing cholangitis
Gastroenterology, 134 (4), 975-80
DOI 10.1053/j.gastro.2008.01.042, PubMed 18395078

Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S (2008)
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Nat Genet, 40 (6), 713-5
DOI 10.1038/ng.148, PubMed 18438405

Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, IBSEN study group, Mathew CG et al. (2008)
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Nat Genet, 40 (11), 1319-23
DOI 10.1038/ng.221, PubMed 18836448

Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Bianchi FB, Shibata M, Schramm C, Eisenmann de Torres B, Galle PR, McFarlane I, Dienes HP, Lohse AW, International Autoimmune Hepatitis Group (2008)
Simplified criteria for the diagnosis of autoimmune hepatitis
Hepatology, 48 (1), 169-76
DOI 10.1002/hep.22322, PubMed 18537184

Hov JR, Boberg KM, Karlsen TH (2008)
Autoantibodies in primary sclerosing cholangitis
World J Gastroenterol, 14 (24), 3781-91
DOI 10.3748/wjg.14.3781, PubMed 18609700

Karlsen TH, Schrumpf E, Boberg KM (2008)
Gallbladder polyps in primary sclerosing cholangitis: not so benign
Curr Opin Gastroenterol, 24 (3), 395-9
DOI 10.1097/MOG.0b013e3282f5727a, PubMed 18408471

Melum E, Buch S, Schafmayer C, Kalthoff H, Tepel J, Schreiber S, Karlsen TH, Hampe J (2008)
Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma
Int J Cancer, 123 (1), 241-2
DOI 10.1002/ijc.23517, PubMed 18398827

Melum E, Karlsen TH, Bergquist A, Schrumpf E, Boberg KM (2008)
An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis
Am J Gastroenterol, 103 (4), 1045; author reply 1045-6
DOI 10.1111/j.1572-0241.2007.01772_5.x, PubMed 18397431

Melum E, Karlsen TH, Schrumpf E, Bergquist A, Thorsby E, Boberg KM, Lie BA (2008)
Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms
Hepatology, 47 (1), 90-6
DOI 10.1002/hep.21964, PubMed 18023027

Publications 2007

Lindner E, Nordang GB, Melum E, Flatø B, Selvaag AM, Thorsby E, Kvien TK, Førre OT, Lie BA (2007)
Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis
BMC Med Genet, 8, 33
DOI 10.1186/1471-2350-8-33, PubMed 17565662

Melum E, Friman S, Bjøro K, Rasmussen A, Isoniemi H, Gjertsen H, Bäckman L, Oksanen A, Olausson M, Duraj FF, Ericzon BG (2007)
Hepatitis C impairs survival following liver transplantation irrespective of concomitant hepatocellular carcinoma
J Hepatol, 47 (6), 777-83
DOI 10.1016/j.jhep.2007.06.013, PubMed 17714825